秦宝明

  • 博士,博士生导师
  • 办公室:E306
  • 研究员,代谢和细胞命运研究组
  • 电话:Null
  • 研究组长,中科院再生生物学重点实验室
  • 电子邮箱:qin_baoming@gibh.ac.cn
个人简介
国家重点研发计划项目负责人,国家自然科学二等奖获得者,中国科学院杰出科技成就奖获得者,广东省自然科学一等奖获得者,广东省“特支计划”科技创新领军人才,广州开发区“黄埔人才”。
2013.9-现在,研究员,中国科学院广州生物医药与健康研究院
2010.7-2013.8,副研究员,中国科学院广州生物医药与健康研究院
2004.9-2007.8,助理研究员,中国科学院广州生物医药与健康研究院
2007.9-2010.6,博士,细胞生物学,中国科学院广州生物医药与健康研究院
1994.9-1998.6,学士,生物化学与分子生物学,北京大学生命科学学院
研究兴趣
• 衰老主要通路mTORC1-线粒体在干细胞稳态维持和命运决定中的作用和机制;
• 胚胎发育早期不同命运干细胞的转录和表观遗传调控机理。
发表论文
(代表论著)
1. Xueting Xu, …, Baoming Qin. (2021) The mTORC1-eIF4F axis controls paused pluripotency. EMBO Reports, e53081. DOI: 10.15252/embr.202153081.
2. Yinghua Huang, Hui Zhang, …, Miguel A. Esteban*, Baoming Qin*. (2020) JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications, 11: 5061-5076. (*co-corresponding author)
3. Zicong Liu, …, Gongcheng Hu*, Baoming Qin*. (2019) Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology. Stem Cell Research, 41: 101638-101641. (*co-corresponding author)
4. Lulu Wang, …, Baoming Qin. (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal, DOI: 10.1111/febs.15024.
5. Yasong Wu, Yuan Li, …, Baoming Qin*, Duanqing Pei*. (2015) Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology, 17: 715-725. (*co-corresponding author)
6. Xichen Bao, …, Baoming Qin*, Miguel Angel Esteban*. (2013) MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology, 25: 208-214. (*co-corresponding author)
7. Jianbin Su, …, Baoming Qin. (2013) Roles of small molecules in somatic cell reprogramming. Acta Pharmacologica Sinica, 34: 719-724.
8. Miguel Angel Esteban#, Tao Wang#, Baoming Qin#, …, Duanqing Pei. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell, 6 (1): 1-9. (#co-first author; cover story)
9. Baoming Qin, …, Duanqing Pei. (2006) Sorting nexin 10 induces giant vacuoles in mammalian cells. Journal of Biological Chemistry, 281 (48): 36891-36896. (cover story)
10. Baoming Qin, …, Duanqing Pei. (2005) Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research, 15 (3): 212-217.
11. Ping Cui#, Baoming Qin#, …, Duanqing Pei. (2004) Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals. Experimental Cell Research, 293: 154-163. (#co-first author)
 
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