王涛

  • 博士,博士生导师
  • 办公室:E205
  • 研究员,衰老与再生研究组
  • 电话:020-32218627
  • 研究组长,中科院再生生物学重点实验室
  • 电子邮箱:wang_tao@gibh.ac.cn
个人简介
2010年在中科院广州生物医药与健康研究院取得博士学位;2012-2015年在北卡莱罗纳大学教堂山分校Norman E. Sharpless教授实验室作为博士后进行衰老相关研究;2015-2017年在耶鲁大学Andrew Xiao实验室研究一种新型的6mA-DNA表观修饰。
研究兴趣
主要研究方向是6mA-DNA修饰的生物学功能和调控机制,细胞衰老(senescence)与生物衰老(ageing)以及癌症等老年疾病之间的关联。
发表论文
(代表性5篇)
1. Wu TP, Wang T, Seetin MG, Lai Y, Zhu S, Lin K, Liu Y, Byrum SD, Mackintosh SG, Zhong M, Tackett A, Wang G, Hon LS, Fang G, Swenberg JA, Xiao AZ*. DNA methylation on N(6)-adenine in mammalian embryonic stem cells. Nature. 2016, 532: 329-333.
2. Chen K, Long Q, Wang T, Zhao D, Zhou Y, Qi J, Wu Y, Li S, Chen C, Zeng X, Yang J, Zhou Z, Qin W, Liu X, Li Y, Huang X, Qin D, Chen J, Pan G, Scholer HR, Xu G, Liu X*, Pei D*. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO Rep. 2016, 17: 1641-1656.
3. Esteban, M.A.#, Wang, T.#, Qin, B.#, Yang, J., Qin, D., Cai, J., Li, W., Weng, Z., Chen, J., Ni, S., Chen, K., Li, Y., Liu, X., Xu, J., Zhang, S., Li, F., He, W., Labuda, K., Song, Y., Peterbauer, A., Wolbank, S., Redl, H., Zhong, M., Cai, D., Zeng, L., and Pei, D*. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010, 6(1): 71-79. (#Contributed equally).
4. Wang, T., Chen, K., Zeng, X., Yang, J., Wu, Y., Shi, X., Qin, B., Zeng, L., Esteban, M.A., Pan, G., and Pei, D*. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell. 2011, 9(6): 575-587.
5. Chen, J., Liu, H., Liu, J., Qi, J., Wei, B., Yang, J., Liang, H., Chen, Y., Wu, Y., Guo, L., Zhu, J., Zhao, X., Peng, T., Zhang, Y., Chen, S., Li, X., Li, D., Wang, T., and Pei, D*. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet. 2013, 45(1): 34-42.
个人履历