胡功成

  • 博士
  • 办公室:E313
  • 副研究员,干细胞和肿瘤细胞表观遗传调控研究组
  • 电话:Null
  • 研究骨干,中科院再生生物学重点实验室
  • 电子邮箱:hu_gongcheng@gibh.ac.cn
个人简介

2009年本科毕业于中山大学药学院,2014年硕士毕业于广州医科大学公共卫生学院,2019年博士毕业于中国科学院广州生物医药与健康研究院,并从事博士后工作。2022年1月起聘为中国科学院广州生物医药与健康研究院副研究员。

研究兴趣

表观遗传(染色质高级结构、组蛋白修饰等)在细胞命运转变中的机制研究

发表论文

(代表性5篇)
1. Gongcheng Hu#, Xiaotao Dong#, Shixin Gong#, Yawei Song, Andrew P Hutchins, Hongjie Yao. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research. 2020 Sep 4;gkaa705. doi: 10.1093/nar/gkaa705.
2. Jiao Li#, Kaimeng Huang#, Gongcheng Hu#, Isaac Babarinde, Yaoyi Li, Xiaotao Dong, Yu-Sheng Chen, Liping Shang, Wenjing Guo, Junwei Wang, Zhaoming Chen, Andrew P. Hutchins, Yun-Gui Yang, Hongjie Yao. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nature Communications. 2019 Apr 4;10(1):1535. doi: 10.1038/s41467-019-08949-w.
3. Gongcheng Hu#, Ti Yang#, Jingli Zheng#, Jiabing Dai, Aruo Nan, Yandong Lai, Yajie Zhang, Chengfeng Yang, and Yiguo Jiang. Functional role and mechanism of lncRNA LOC728228 in malignant 16HBE cells transformed by anti-benzopyrene-trans-7,8-dihydrodiol-9,10-epoxide. Molecular Carcinogenesis. 2015 Jun;54 Suppl 1:E192-204. doi: 10.1002/mc.22314. Epub 2015 Mar 27.
4. Zicong Liu, Mingze Yao, Hongjie Yao, Gongcheng Hu*, Baoming Qin*. Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-by using CRISPR/Cas9 technology. Stem Cell Research. 2019 Dec; 41: 101638. doi: 10.1016/j.scr.2019.101638. Epub 2019 Oct 26.
5. Yawei Song, Gongcheng Hu, Jinping Jia, Mingze Yao, Xiaoshan Wang, Wenliang Lu, Andrew P Hutchins, Jiekai Chen, Keiko Ozato, Hongjie Yao. DNA Damage Induces Dynamic Associations of BRD4/P-TEFb With Chromatin and Modulates Gene Transcription in a BRD4-Dependent and -Independent Manner. Frontier in Molecular Biosciences. 2020 Dec 4;7:618088. doi: 10.3389/fmolb.2020.618088.
 
 

个人履历

Null