王东业

  • 博士
  • 办公室:E304
  • 副研究员,细胞命运转变与表观遗传调控研究组
  • 电话:Null
  • 研究骨干,中科院再生生物学重点实验室
  • 电子邮箱:wang_dongye@gibh.ac.cn
个人简介

1996年本科毕业于南京大学化学化工学院,2008年毕业于美国罗格斯大学,获哲学博士学位。2008年11月起受聘于中国科学院广州生物医药与健康研究院,历任助理研究员、副研究员。

研究兴趣

利用人iPS细胞分化的神经细胞和类脑器官作为疾病模型,研究帕金森病等神经退行性疾病的发生机理。

发表论文

(代表性5篇)
1. Shuhan Chen, Zhiwei Luo, Carl Ward, David P. Iba?ez, Hao Liu, Xiaofen Zhong, Narendra K. Sharma, Baoming Qin, Wenxia Fan, Dongye Wang*. Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9. Stem Cell Research. 2020, 45: 101804.
2. Wei Lin#, Kalyan Das#*, David Degen#, Abhishek Mazumder, Diego Duchi, Dongye Wang, Yon W. Ebright, Richard Y. Ebright, Elena Sineva, Matthew Gigliotti, Aashish Srivastava, Sukhendu Mandal, Yi Jiang, Yu Liu, Ruiheng Yin, Zhening Zhang, Edward T. Eng, Dennis Thomas, Stefano Donadio, Haibo Zhang, Changsheng Zhang, Achillefs N. Kapanidis, Richard H. Ebright*. Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3). Molecular Cell. 2018, 70(1): 60-71.
3. Li Xiaodan#,Wang Lili#,Zhou X Edward#,Ke Jiyuan,de Waal Parker W,Gu Xin,Tan M H Eileen,Wang Dongye,Wu Donghai,Xu H Eric*,Melcher Karsten*. Structural basis of AMPK regulation by adenine nucleotides and glycogen. Cell Research. 2015,25(1):50-66。
4. Chakraborty A, Wang D, Ebright YW, Korlann Y, Kortkhonjia E, Kim T, Chowdhury S, Wigneshweraraj S, Irschik H, Jansen R, Nixon BT, Knight J, Weiss S, Ebright RH*. Opening and closing of the bacterial RNA polymerase clamp. Science. 2012, 337: 591-595.
5. Chakraborty A.#, Wang Dongye#, Ebright Y. W., and Ebright, R. H.*. Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation: phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy. Methods Enzymol. 2010, 472: 19-30. 
 

个人履历

http://www.gibh.cas.cn/sourcedb_gibh_cas/zw/zjrc/201202/t20120208_3435453.html