郭琳

  • 博士,硕士生导师
  • 办公室:F310
  • 副研究员,细胞命运转换研究组
  • 电话:Null
  • 研究骨干,中科院再生生物学重点实验室
  • 电子邮箱:guo_lin@gibh.ac.cn
个人简介

2009年本科毕业于南京农业大学,2014年于中国科学院大学获理学博士学位。2014年8月起受聘于中国科学院广州生物医药与健康研究院,历任助理研究员、副研究员。

研究兴趣

围绕细胞命运决定:1)体细胞重编程机制;2)细胞周期影响细胞命运决定机制。

发表论文

(代表性5篇)
1. Lin Guo#, Lihui Lin#, Xiaoshan Wang#, Mingwei Gao, ......, Duanqing Pei*, Jiekai Chen*. Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. Molecular Cell. 2019, 73(4): 815-829.e7.
2. Jiekai Chen#, Lin Guo#, Lei Zhang#, Haoyu Wu, ......, Guoliang Xu*, Duanqing Pei*. Vitamin C modulates TET1 function during somatic cell reprogramming. Nature Genetics. 2013, 45(12): 1504-1509.
3. Yulin Chen#, Lin Guo#, Jiekai Chen#, Xiangjie Zhao, ......, Li Jin*, Duanqing Pei*, Feng Zhang*. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity. BMC Genomics. 2014, 15(1): 79.
4. Xiaowei Lai#, Qian Li#, Fang Wu, Jiechun Lin, Jiekai Chen*, Hui Zheng*, Lin Guo*. Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming. Frontiers in Cell and Development Biology. 2020, 8: 760.
5. Dongwei Li#, Jing Liu#, Xuejie Yang#, Chunhua Zhou, Jing Guo, Chuman Wu, Yue Qin, Lin Guo, ......, Jiekai Chen*, Duanqing Pei*. Chromatin Accessibility Dynamics during iPSC Reprogramming. Cell Stem Cell. 2017, 21(6): 819-833.

个人履历

http://www.gibh.cas.cn/sourcedb_gibh_cas/zw/zjrc/201412/t20141229_4282875.html