王可品

  • 博士,硕士生导师
  • 办公室:F202
  • 副研究员,干细胞转基因克隆研究组
  • 电话:020-32015304
  • 研究骨干,中科院再生生物学重点实验室
  • 电子邮箱:wang_kepin@gibh.ac.cn
个人简介

2011年本科毕业于安徽大学生物工程专业,2016年博士毕业于中国科学院广州生物医药与健康研究院。2016年起受聘于中国科学院广州生物医药与健康研究院,历任助理研究员、副研究员。

研究兴趣

新型基因编辑工具开发及优化;基因修饰大动物模型培育及其应用。

发表论文

(代表性5篇)
1. Nan Li#, Shixue Gou#, Jiaowei Wang#, Quanjun Zhang, Xingyun Huang, Jingke Xie, Li Li, Qin Jin, Zhen Ouyang, Fangbing Chen, Weikai Ge, Hui Shi, Yanhui Liang, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Yinghua Ye, Longquan Quan, Han Wu*, Liangxue Lai*, Kepin Wang*. CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I. Molecular Therapy. 2020 Nov 19. *共同通讯作者
2. Wenjing Li#, Lei Shi#, Zhenpeng Zhuang#, Han Wu#, Meng Lian, Yihui Chen, Lei Li, Weikai Ge, Qin Jin, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Zhen Ouyang, Yinghua Ye, Yingying Li, Hai Wang, Yuan Liao, Longquan Quan, Lei Xiao, Liangxue Lai*, Guangxun Meng*, Kepin Wang*. Engineered pigs carrying a gain-of-function NLRP3 homozygous mutation can survive to adult and accurately recapitulate human systemic spontaneous inflammatory responses. The Journal of Immunology. 2020, 205(9): 2532-2544. *共同通讯作者
3. Jingke Xie#, Xingyun Huang#, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang*, Liangxue Lai*. ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems. BMC Biology. 2020, 18(1): 131. *共同通讯作者
4. Jingke Xie#, Weikai Ge#, Nan Li#, Qishuai Liu#, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang*, Liangxue Lai*. Efficient base editing for multiple genes/loci in pigs using base editors. Nature Communications. 2019, 10(1): 2852. *共同通讯作者
5. Kepin Wang#, Qin Jin#, Degong Ruan#, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li*, Liangxue Lai*. Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing. Genome Research. 2017, 27(12): 2061-2071. 

个人履历

http://www.gibh.cas.cn/sourcedb_gibh_cas/zw/zjrc/201803/t20180323_4982160.html