重要文章

• Yan Q, Zhang Y, Hou R, Pan W, Liang H, Gao X, Deng W, Huang X, Qu L, Tang C, He P, Liu B, Wang Q, Zhao X, Lin Z, Chen Z, Li P, Han J, Xiong X, Zhao J, Li S, Niu X, Chen L. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents. Emerg Microbes Infect. 2024 Dec;13(1):2290841. doi: 10.1080/22221751.2023.2290841. Epub 2024 Jan 24. PMID: 38044868; PMCID: PMC10810631.
• Li P, Wang Q, He Y, Yang C, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L, Chen L. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerg Microbes Infect. 2023 Dec;12(1):e2136538. doi: 10.1080/22221751.2022.2136538. PMID: 36239345; PMCID: PMC9980405.
• Li L, Sun S, Wu Y, Lu J, He J, Chen K, Chan WY, Liu X. Lactate and protein lactylation: the ugly duckling of energy as the sculpture artist of proteins. Sci Bull (Beijing). 2023 Nov 15;68(21):2510-2514. doi: 10.1016/j.scib.2023.09.038. Epub 2023 Sep 27. PMID: 37806798.
• Liao R, Wu Y, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X, Li P. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO J. 2023 Nov 2;42(21):e113448. doi: 10.15252/embj.2023113448. Epub 2023 Sep 22. PMID: 37737560; PMCID: PMC10620766.
• Xie J, Zhuang Z, Gou S, Zhang Q, Wang X, Lan T, Lian M, Li N, Liang Y, Ouyang Z, Ye Y, Wu H, Lai L, Wang K. Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription. Nucleic Acids Res. 2023 Oct 13;51(18):10075-10093. doi: 10.1093/nar/gkad687. PMID: 37650635; PMCID: PMC10570039.
• Dong S, Li H, Wang M, Rasheed N, Zou B, Gao X, Guan J, Li W, Zhang J, Wang C, Zhou N, Shi X, Li M, Zhou M, Huang J, Li H, Zhang Y, Wong KH, Zhang X, Chao WCH, He J. Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res. 2023 Oct;33(10):790-801. doi: 10.1038/s41422-023-00869-1. Epub 2023 Sep 4. PMID: 37666978; PMCID: PMC10542350.
• Wang J, Xie W, Li N, Li W, Zhang Z, Fan N, Ouyang Z, Zhao Y, Lai C, Li H, Chen M, Quan L, Li Y, Jiang Y, Jia W, Fu L, Mazid MA, Zhu Y, Maxwell PH, Pan G, Esteban MA, Dai Z, Lai L. Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation. Cell Stem Cell. 2023 Sep 7;30(9):1235-1245.e6. doi: 10.1016/j.stem.2023.08.003. PMID: 37683604.
• Xu X, Qin B. Pausing pluripotency via RNA methylation. Nat Cell Biol. 2023 Sep;25(9):1241-1242. doi: 10.1038/s41556-023-01203-y. PMID: 37696946.
• Zhao S, Nie T, Li L, Long Q, Gu P, Zhang Y, Sun W, Lin Z, Liu Q, Qi Y, Wang W, Xie M, Loomes K, Cai C, Wu D, Hui HX. Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte. Adv Sci (Weinh). 2023 Jul;10(21):e2300070. doi: 10.1002/advs.202300070. Epub 2023 May 21. PMID: 37211698; PMCID: PMC10375129.
• Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K, Peng G. Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods. 2023 Jul;20(7):1048-1057. doi: 10.1038/s41592-023-01884-1. Epub 2023 May 25. PMID: 37231265.
• Habimana JD, Mukama O, Chen G, Chen M, Amissah OB, Wang L, Liu Y, Sun Y, Li AL, Deng S, Huang J, Yan XX, Rutaganda T, Mutangana D, Wu LP, Huang R, Li Z. Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer. Biosens Bioelectron. 2023 Feb 15;222:114939.
• Jin Q, Liu X, Zhuang Z, Huang J, Gou S, Shi H, Zhao Y, Ouyang Z, Liu Z, Li L, Mao J, Ge W, Chen F, Yu M, Guan Y, Ye Y, Tang C, Huang R, Wang K, Lai L. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation. Genome Biol. 2023 Jan 17;24(1):8. doi: 10.1186/s13059-023-02851-x. PMID: 36650523; PMCID: PMC9843877.

所有文章

• Li C, Jiao Y, Shen S, Zhao W, Zhang Q, Zhang S. Chaenomeles sinensis polysaccharide and its carboxymethylated derivative alleviate dextran sulfate sodium-induced ulcerative colitis via suppression of inflammation and oxidative stress. Biomed Pharmacother. 2023 Dec 31;169:115941.
• Yan Q, Zhang Y, Hou R, Pan W, Liang H, Gao X, Deng W, Huang X, Qu L, Tang C, He P, Liu B, Wang Q, Zhao X, Lin Z, Chen Z, Li P, Han J, Xiong X, Zhao J, Li S, Niu X, Chen L. Deep immunoglobulin repertoire sequencing depicts a comprehensive atlas of spike-specific antibody lineages shared among COVID-19 convalescents. Emerg Microbes Infect. 2024 Dec;13(1):2290841.
• Li P, Wang Q, He Y, Yang C, Zhang Z, Liu Z, Liu B, Yin L, Cui Y, Hu P, Liu Y, Zheng P, Wang W, Qu L, Sun C, Guan S, Feng L, Chen L. Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques. Emerg Microbes Infect. 2023 Dec;12(1):e2136538.
• Zhao K, Zhang H, Cui J, Zhang Y, Zhou T, Long B. Generation of an NSD2-deficient human embryonic stem cell line using CRISPR/Cas9 technology. Stem Cell Res. 2023 Dec;73:103255. doi: 10.1016/j.scr.2023.103255. Epub 2023 Nov 19. PMID: 37992565.
• Liang L, He M, Zhang Y, Wang C, Qin Z, Li Q, Yang T, Meng F, Zhou Y, Ge H, Song W, Chen S, Dong L, Ren Q, Li C, Guo L, Sun H, Zhang W, Pei D, Zheng H. Unraveling the 2,3-diketo-L-gulonic acid-dependent and -independent impacts of L-ascorbic acid on somatic cell reprogramming. Cell Biosci. 2023 Nov 30;13(1):218.
• Huang FF, Cui WH, Ma LY, Chen Q, Liu Y. Crosstalk of nervous and immune systems in pancreatic cancer. Front Cell Dev Biol. 2023 Nov 30;11:1309738. doi: 10.3389/fcell.2023.1309738. PMID: 38099290; PMCID: PMC10720593.
• Li H, Chang L, Wu J, Huang J, Guan W, Bates LE, Stuart HT, Guo M, Zhang P, Huang B, Chen C, Zhang M, Chen J, Min M, Wu G, Hutchins AP, Silva JCR. In vitro generation of mouse morula-like cells. Dev Cell. 2023 Nov 20;58(22):2510-2527.e7
• Peng K, Xie W, Wang T, Li Y, de Dieu Habimana J, Amissah OB, Huang J, Chen Y, Ni B, Li Z. HIF-1α promotes kidney organoid vascularization and applications in disease modeling. Stem Cell Res Ther. 2023 Nov 19;14(1):336.
• Li L, Sun S, Wu Y, Lu J, He J, Chen K, Chan WY, Liu X. Lactate and protein lactylation: the ugly duckling of energy as the sculpture artist of proteins. Sci Bull (Beijing). 2023 Nov 15;68(21):2510-2514.
• Zhao D, Gao X, Zhou J, Li J, Qian Y, Wang D, Niu W, Zhang T, Hu M, Xiong H, Lai L, Li Z. Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope. BMC Biol. 2023 Nov 9;21(1):250.
• Cao J, Li W, Li J, Mazid MA, Li C, Jiang Y, Jia W, Wu L, Liao Z, Sun S, Song W, Fu J, Wang Y, Lu Y, Xu Y, Nie Y, Bian X, Gao C, Zhang X, Zhang L, Shang S, Li Y, Fu L, Liu H, Lai J, Wang Y, Yuan Y, Jin X, Li Y, Liu C, Lai Y, Shi X, Maxwell PH, Xu X, Liu L, Poo M, Wang X, Sun Q, Esteban MA, Liu Z. Live birth of chimeric monkey with high contribution from embryonic stem cells. Cell. 2023 Nov 9;186(23):4996-5014.e24.
• Qian Y, Wang D, Niu W, Shi Z, Wu M, Zhao D, Li J, Gao X, Zhang Z, Lai L, Li Z. Development of a highly efficient prime editor system in mice and rabbits. Cell Mol Life Sci. 2023 Nov 4;80(11):346.
• Liao R, Wu Y, Qin L, Jiang Z, Gou S, Zhou L, Hong Q, Li Y, Shi J, Yao Y, Lai L, Li Y, Liu P, Thiery JP, Qin D, Graf T, Liu X, Li P. BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO J. 2023 Nov 2;42(21):e113448.
• Zhou L, Li H, Sun T, Wen X, Niu C, Li M, Li W, Esteban MA, Hoffman AR, Hu JF, Cui J. Profiling mitochondria-polyribosome lncRNAs associated with pluripotency. Sci Data. 2023 Nov 2;10(1):755.
• Wang D, Huang J, Zhang H, Gu TJ, Li L. Cotton Ti-IMAC: Developing Phosphorylated Cotton as a Novel Platform for Phosphopeptide Enrichment. ACS Appl Mater Interfaces. 2023 Oct 18;15(41):47893-47901.
• Tian R, Li Y, Zhao H, Lyu W, Zhao J, Wang X, Lu H, Xu H, Ren W, Tan QQ, Shi Q, Wang GD, Zhang YP, Lai L, Mi J, Jiang YH, Zhang YQ. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing. Mol Psychiatry. 2023 Sep;28(9):3739-3750.
• Bao X, Li X, Wu WKK, Zhang Y, Zhou L. Editorial: Protein-RNA interplay-regulated signaling in stem cells and cancer. Front Cell Dev Biol. 2023 Oct 16;11:1304817. doi: 10.3389/fcell.2023.1304817.
• Li D, Luo L, Guo L, Wu C, Zhang R, Peng Y, Wu M, Kuang J, Li Y, Zhang Y, Xie J, Xie W, Mao R, Ma G, Fu X, Chen J, Hutchins AP, Pei D. c-Jun as a one-way valve at the naive to primed interface. Cell Biosci. 2023 Oct 14;13(1):191.
• Xie J, Zhuang Z, Gou S, Zhang Q, Wang X, Lan T, Lian M, Li N, Liang Y, Ouyang Z, Ye Y, Wu H, Lai L, Wang K. Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription. Nucleic Acids Res. 2023 Oct 13;51(18):10075-10093
• Dong S, Li H, Wang M, Rasheed N, Zou B, Gao X, Guan J, Li W, Zhang J, Wang C, Zhou N, Shi X, Li M, Zhou M, Huang J, Li H, Zhang Y, Wong KH, Zhang X, Chao WCH, He J. Structural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex. Cell Res. 2023 Oct;33(10):790-801.
• Peng X, Mao Y, Tai Y, Luo B, Dai Q, Wang X, Wang H, Liang Y, Guan R, Liu C, Guo Y, Chen L, Zhang Z, Wang H. Characterization of Anxiety-Like Behaviors and Neural Circuitry following Chronic Moderate Noise Exposure in Mice. Environ Health Perspect. 2023 Oct;131(10):107004.
• Shi X, Wu W, Feng Z, Fan P, Shi R, Zhang X. MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy. Cell Rep. 2023 Sep 26;42(9):113045. doi: 10.1016/j.celrep.2023.113045. Epub 2023 Aug 26. PMID: 37632749.
• Ge W, Zhao X, Gou S, Jin Q, Chen F, Ouyang Z, Lai C, Cui T, Mai B, Lu S, Zhong K, Liang Y, Chen T, Wu H, Li N, Ye Y, Lai L, Wang K. Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos. Mol Ther Nucleic Acids. 2023 Sep 20;34:102035. doi: 10.1016/j.omtn.2023.102035. PMID: 37808924; PMCID: PMC10551558.
• Lan W, Quan L, Li Y, Ou J, Duan B, Mei T, Tan X, Chen W, Feng L, Wan C, Zhao W, Chodosh J, Seto D, Zhang Q. Isolation of novel simian adenoviruses from macaques for development of a vector for human gene therapy and vaccines. J Virol. 2023 Oct 31;97(10):e0101423.
• Wang R, Yang X, Chen J, Zhang L, Griffiths JA, Cui G, Chen Y, Qian Y, Peng G, Li J, Wang L, Marioni JC, Tam PPL, Jing N. Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation. Nat Commun. 2023 Sep 14;14(1):5675.
• Lan T, Chen H, Tang C, Wei Y, Liu Y, Zhou J, Zhuang Z, Zhang Q, Chen M, Zhou X, Chi Y, Wang J, He Y, Lai L, Zou Q. Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase. Mol Ther Nucleic Acids. 2023 Aug 18;33:890-897. doi: 10.1016/j.omtn.2023.08.018. PMID: 37680986; PMCID: PMC10480570.
• Zhao F, Zhang T, Sun X, Zhang X, Chen L, Wang H, Li J, Fan P, Lai L, Sui T, Li Z. A strategy for Cas13 miniaturization based on the structure and AlphaFold. Nat Commun. 2023 Sep 8;14(1):5545.
• Wang J, Xie W, Li N, Li W, Zhang Z, Fan N, Ouyang Z, Zhao Y, Lai C, Li H, Chen M, Quan L, Li Y, Jiang Y, Jia W, Fu L, Mazid MA, Zhu Y, Maxwell PH, Pan G, Esteban MA, Dai Z, Lai L. Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation. Cell Stem Cell. 2023 Sep 7;30(9):1235-1245.e6.
• Xu X, Qin B. Pausing pluripotency via RNA methylation. Nat Cell Biol. 2023 Sep;25(9):1241-1242. doi: 10.1038/s41556-023-01203-y. PMID: 37696946.
• Chen T, Tang C, Zheng W, Qian Y, Chen M, Zou Q, Jin Y, Wang K, Zhou X, Gou S, Lai L. VCFshiny: an R/Shiny application for interactively analyzing and visualizing genetic variants. Bioinform Adv. 2023 Aug 26;3(1):vbad107.
• Li C, He J, Meng F, Wang F, Sun H, Zhang H, Dong L, Zhang M, Xu Q, Liang L, Li Y, Yang T, He M, Wang T, Lin J, Sun J, Huang Q, Guo L, Zhang X, Mai S, Zheng H. Nuclear localization of TET2 requires β-catenin activation and correlates with favourable prognosis in colorectal cancer. Cell Death Dis. 2023 Aug 24;14(8):552.
• Zhong H, Zhang R, Li G, Huang P, Zhang Y, Zhu J, Kuang J, Hutchins AP, Qin D, Zhu P, Pei D, Li D. c-JUN is a barrier in hESC to cardiomyocyte transition. Life Sci Alliance. 2023 Aug 21;6(11):e202302121.
• Yin D, Han Z, Lang B, Li Y, Mai G, Chen H, Feng L, Chen YQ, Luo H, Xiong Y, Jing L, Du X, Shu Y, Sun C. Effect of seasonal coronavirus immune imprinting on the immunogenicity of inactivated COVID-19 vaccination. Front Immunol. 2023 Aug 16;14:1195533.
• de Dieu Habimana J, Mukama O, Amissah OB, Sun Y, Karangwa E, Liu Y, Mugisha S, Cheng N, Wang L, Chen J, Deng S, Huang R, Li Z. A Rationally Designed CRISPR/Cas12a Assay Using a Multimodal Reporter for Various Readouts. Anal Chem. 2023 Aug 8;95(31):11741-11750.
• Zhou J, Wang J, Chen F, Zhuang Z, Chen M, Yang Y, Luo X, Tang C, Zhou X, Chi Y, Wang J, He Y, Zhang K, Zou Q. Improved USER cloning for TALE assembly and its application to base editing. PLoS One. 2023 Aug 4;18(8):e0289509. doi: 10.1371/journal.pone.0289509. PMID: 37540669; PMCID: PMC10403120.
• Feng Z, Fang P, Zheng H, Zhang X. DEP2: an upgraded comprehensive analysis toolkit for quantitative proteomics data. Bioinformatics. 2023 Aug 1;39(8):btad526. doi: 10.1093/bioinformatics/btad526. PMID: 37624922; PMCID: PMC10466079.
• Cui Y, Yuan T, Wang Y, Zheng D, Qin L, Li S, Jiang Z, Lin S, Guo W, Wang Z, Liang Z, Li Y, Yao Y, Liu X, Tang Q, Tu HY, Zhang XC, Tang Z, Wong N, Zhang Z, Qin D, Thiery JP, Xu K, Li P. T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity. Cell Rep. 2023 Jul 25;42(7):112797.
• Liang Y, Chen F, Wang K, Lai L. Base editors: development and applications in biomedicine. Front Med. 2023 Jun;17(3):359-387. doi: 10.1007/s11684-023-1013-y. Epub. 2023 Jul 12. PMID: 37434066.
• Qian Y, Wang D, Niu W, Zhao D, Li J, Liu Z, Gao X, Han Y, Lai L, Li Z. A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9. BMC Biol. 2023 Jul 11;21(1):155.
• Zhang X, Li Z, Zhang Y, Liu Y, Wang J, Liu B, Chen Q, Wang Q, Fu L, Wang P, Zhong X, Jin L, Yan Q, Chen L, He J, Zhao J, Xiong X. Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes. Life Sci Alliance. 2023 Jul 4;6(9):e202201796.
• Zhao S, Nie T, Li L, Long Q, Gu P, Zhang Y, Sun W, Lin Z, Liu Q, Qi Y, Wang W, Xie M, Loomes K, Cai C, Wu D, Hui HX. Androgen Receptor is a Negative Regulator of PRDM16 in Beige Adipocyte. Adv Sci (Weinh). 2023 Jul;10(21):e2300070. doi: 10.1002/advs.202300070. Epub 2023 May 21. PMID: 37211698; PMCID: PMC10375129.
• Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K, Peng G. Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods. 2023 Jul;20(7):1048-1057.
• Long Q, Zhou Y, Guo J, Wu H, Liu X. Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei. Biophys Rep. 2023 Jun 30;9(3):113-119. doi: 10.52601/bpr.2023.220018. PMID: 38028151; PMCID: PMC10648231.
• Liu Q, Long Q, Zhao J, Wu W, Lin Z, Sun W, Gu P, Deng T, Loomes KM, Wu D, Kong APS, Zhou J, Cheng AS, Hui HX. Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing. Research (Wash D C). 2023 Jun 28;6:0182.
• Zhao Y, Fan W, Liu A, Pan S, Xu C, Peng H, Yin B, Wang X, Dong J, Pan Z. Non-Invasive and Label-Free On-Chip Impedance Monitoring of Heatstroke. Biosensors (Basel). 2023 Jun 27;13(7):686. doi: 10.3390/bios13070686. PMID: 37504085; PMCID: PMC10377158.
• Jin Y, Chen T, Zheng W, Xi J, Zi Y, Wang J, Chi Y, Chen M, Zou Q, Tang C, Lai L, Zhou X. Generation of hiPSCs with ABO c.767T>C substitution: resulting in splicing variants. Front Genet. 2023 Jun 15;14:1141756. doi: 10.3389/fgene.2023.1141756. PMID: 37396040; PMCID: PMC10310534.
• Liu X, Yang J, Li Z, Liu R, Wu X, Zhang Z, Lai L, Li Z, Song Y. YIPF5 (p.W218R) mutation induced primary microcephaly in rabbits. Neurobiol Dis. 2023 Jun 15;182:106135. doi: 10.1016/j.nbd.2023.106135. Epub 2023 May 2. PMID: 37142085.
• Luo X, Yang K, Jiang M, Chen T, Chi Y, Ma B, Lai L, Zou Q. Generation of a homozygous GRIN2A gene knockout human embryonic stem cell line using CRISPR/Cas9 system. Stem Cell Res. 2023 Jun;69:103121. doi: 10.1016/j.scr.2023.103121. Epub 2023 May 9. PMID: 37182381.
• Meng S, Li M, Qin L, Lv J, Wu D, Zheng D, Jia H, Chen D, Wu Q, Long Y, Tang Z, Tang Y, Yang L, Yao Y, Luo X, Li P. The onco-embryonic antigen ROR1 is a target of chimeric antigen T cells for colorectal cancer. Int Immunopharmacol. 2023 Aug;121:110402.
• Jiang M, Tang C, Luo X, Zhou X, Chen M, Chi Y, Lai L, Zou Q. Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system. Stem Cell Res. 2023 Sep;71:103136. doi: 10.1016/j.scr.2023.103136. Epub 2023 Jun 7. PMID: 37327621.
• Cao S, Feng H, Yi H, et al. Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage. Cell Res. 2023;33(6):421-433. doi:10.1038/s41422-023-00802-6
• Zhao S, Wu X, Tan Z, Ren Y, Li L, Ou J, Lin Y, Song H, Feng L, Seto D, Wu J, Zhang Q, Rong Z. Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs. J Virol. 2023 May 31;97(5):e0020923.
• Li Y, Yang T, Cheng Y, Hou J, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP, Zheng H. Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Prolif. 2023 May;56(5):e13422.
• Guo PC, Zuo J, Huang KK, Lai GY, Zhang X, An J, Li JX, Li L, Wu L, Lin YT, Wang DY, Xu JS, Hao SJ, Wang Y, Li RH, Ma W, Song YM, Liu C, Liu CY, Dai Z, Xu Y, Sharma AD, Ott M, Ou-Yang Q, Huo F, Fan R, Li YY, Hou JL, Volpe G, Liu LQ, Esteban MA, Lai YW. Cell atlas of CCl 4-induced progressive liver fibrosis reveals stage-specific responses. Zool Res. 2023 May 18;44(3):451-466.
• Yang PP, Ye XW, Liu MQ, Yang JX, Feng XL, Li YJ, Zhang K, Liang HW, Yi Y, Wang L, Liu YX, Yang XL, Shi ZL, Feng LQ, Chen L, Xue Y, Pan-Hammarström Q, Wang H, Zhao Y. Entangling of Peptide Nanofibers Reduces the Invasiveness of SARS-CoV-2. Adv Healthc Mater. 2023 Sep;12(24):e2300673.
• Yan S, Zheng X, Lin Y, Li C, Liu Z, Li J, Tu Z, Zhao Y, Huang C, Chen Y, Li J, Song X, Han B, Wang W, Liang W, Lai L, Li XJ, Li S. Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease. Nat Biomed Eng. 2023 May;7(5):629-646.
• Suen HC, Rao S, Luk ACS, Zhang R, Yang L, Qi H, So HC, Hobbs RM, Lee TL, Liao J. The single-cell chromatin accessibility landscape in mouse perinatal testis development. Elife. 2023 Apr 25;12:e75624. doi: 10.7554/eLife.75624. PMID: 37096870; PMCID: PMC10174692.
• Jia Y, Wang T, Zhao D, Liu Z, Sui T, Chen S, Li J, Lai L, Li Z. Targeted mutagenesis in rabbit using an engineered BhCas12b variant. J Mol Cell Biol. 2023 Apr 20;14(12):mjac076. doi: 10.1093/jmcb/mjac076. PMID: 36572401; PMCID: PMC10129383.
• Zhao R, Fang X, Mai Z, Chen X, Mo J, Lin Y, Xiao R, Bao X, Weng X, Zhou X. Transcriptome-wide identification of single-stranded RNA binding proteins. Chem Sci. 2023 Mar 24;14(15):4038-4047. doi: 10.1039/d3sc00957b. PMID: 37063799; PMCID: PMC10094363.
• Deng M, Wang X, Xiong Z, Tang P. Control of RNA degradation in cell fate decision. Front Cell Dev Biol. 2023 Mar 21;11:1164546. doi: 10.3389/fcell.2023.1164546. PMID: 37025171; PMCID: PMC10070868.
• Sun M, Zhang Q, Zhao B, Huang Q, Wu W, Fan P, Zhang L, Zhang X. Antibody-free approach for ubiquitination profiling by selectively clicking the ubiquitination sites. Anal Chim Acta. 2023 Mar 15;1246:340877. doi: 10.1016/j.aca.2023.340877. Epub 2023 Jan 23. PMID: 36764771.
• Peng H, Lin Y, Hu F, Lv C, Wu B, Weng Q, Liu L, Xia C, Liu X, Zhao Y, Zhang Q, Geng Y, Zhang M, Wang J. Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells. Stem Cell Reports. 2023 Mar 14;18(3):720-735.
• Liu Y, Amissah OB, Huangfang X, Wang L, Dieu Habimana J, Lv L, Ding X, Li J, Chen M, Zhu J, Mukama O, Sun Y, Li Z, Huang R. Large-scale expansion of human umbilical cord-derived mesenchymal stem cells using PLGA@PLL scaffold. Bioresour Bioprocess. 2023;10(1):18.
• Jin L, He J, Feng H, Li S, Liu H, Dong H, Hu M, Huang J, Wu H, Chen J, Qi L, Wu K. Transposable elements activation triggers necroptosis in mouse embryonic stem cells. Cell Death Dis. 2023 Mar 7;14(3):184. doi: 10.1038/s41419-023-05705-3. PMID: 36882393; PMCID: PMC9992707.
• Deng ZH, Ma LY, Chen Q, Liu Y. Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging. Bioessays. 2023 Mar;45(3):e2200121. doi: 10.1002/bies.202200121. Epub 2023 Jan 27. PMID: 36707486.
• Lan T, Zheng Y, Suo Y, Wei Y, Shi H, Yan Q, Zhuang Z, Chen H, Zhang Q, Fan N, Zhao Y, Ouyang Z, Lai C, Liu Z, Zhou J, Tang C, Kim NH, Zou Q, Wang X. Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in. J Genet Genomics. 2023 Mar;50(3):212-215. doi: 10.1016/j.jgg.2022.05.001. Epub 2022 May 20. PMID: 35598861.
• Yu H, Liu B, Zhang Y, Gao X, Wang Q, Xiang H, Peng X, Xie C, Wang Y, Hu P, Shi J, Shi Q, Zheng P, Feng C, Tang G, Liu X, Guo L, Lin X, Li J, Liu C, Huang Y, Yang N, Chen Q, Li Z, Su M, Yan Q, Pei R, Chen X, Liu L, Hu F, Liang D, Ke B, Ke C, Li F, He J, Wang M, Chen L, Xiong X, Tang X. Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants. Nat Commun.
• Zhang S, Zhai M, Xu Y, Han J, Chen J, Xiong Y, Pan S, Wang Q, Yu C, Rao Z, Sun Q, Sui Y, Fan K, Li H, Guo W, Liu C, Bai Y, Zhou J, Quan D, Zhang X. Decellularised spinal cord matrix manipulates glial niche into repairing phase via serglycin-mediated signalling pathway. Cell Prolif. 2023 Sep;56(9):e13429. doi: 10.1111/cpr.13429. Epub 2023 Feb 18. PMID: 36807637; PMCID: PMC10472524.
• Wu B, Zhang Q, Hong P, Liu L, Peng H, Xia C, Wang T, Wang Y, Weng Q, Liu X, Geng Y, Wang J, Wu H. Antigen-specific TCR-T cells from Rag2 gene-deleted pluripotent stem cells impede solid tumour growth in a mouse model. Cell Prolif. 2023 Apr;56(4):e13389. doi: 10.1111/cpr.13389. Epub 2023 Jan 2. PMID: 36592612; PMCID: PMC10068938.
• Habimana JD, Mukama O, Chen G, Chen M, Amissah OB, Wang L, Liu Y, Sun Y, Li AL, Deng S, Huang J, Yan XX, Rutaganda T, Mutangana D, Wu LP, Huang R, Li Z. Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer. Biosens Bioelectron. 2023 Feb 15;222:114939.
• Lin Y, Li C, Wang W, Li J, Huang C, Zheng X, Liu Z, Song X, Chen Y, Gao J, Wu J, Wu J, Tu Z, Lai L, Li XJ, Li S, Yan S. Intravenous AAV9 administration results in safe and widespread distribution of transgene in the brain of mini-pig. Front Cell Dev Biol. 2023 Jan 24;10:1115348.
• Jin Q, Liu X, Zhuang Z, Huang J, Gou S, Shi H, Zhao Y, Ouyang Z, Liu Z, Li L, Mao J, Ge W, Chen F, Yu M, Guan Y, Ye Y, Tang C, Huang R, Wang K, Lai L. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation. Genome Biol. 2023 Jan 17;24(1):8. doi: 10.1186/s13059-023-02851-x. PMID: 36650523; PMCID: PMC9843877.
• Zhao S, Ali AS, Kong X, Zhang Y, Liu X, Skidmore MA, Forsyth CM, Savage GP, Wu D, Xu Y, Francis CL. 1-Benzyloxy-5-phenyltetrazole derivatives highly active against androgen receptor-dependent prostate cancer cells. Eur J Med Chem. 2023 Jan 15;246:114982.
• Chen Y, Yang X, Kitajima S, Quan L, Wang Y, Zhu M, Liu E, Lai L, Yan H, Fan J. Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol. 2023 Jan 10;10:1097137. doi: 10.3389/fcell.2022.1097137. PMID: 36704203; PMCID: PMC9871815.
• Zhang C, Lin H, Zhang Y, Xing Q, Zhang J, Zhang D, Liu Y, Chen Q, Zhou T, Wang J, Shan Y, Pan G. BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency. iScience. 2023 Jan 5;26(2):105939. doi: 10.1016/j.isci.2023.105939. PMID: 36711238; PMCID: PMC9874078.

重要文章

• Li W, Long Q, Wu H, Zhou Y, Duan L, Yuan H, Ding Y, Huang Y, Wu Y, Huang J, Liu D, Chen B, Zhang J, Qi J, Du S, Li L, Liu Y, Ruan Z, Liu Z, Liu Z, Zhao Y, Lu J, Wang J, Chan WY, Liu X. Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nat Commun. 2022 Dec 2;13(1):7414. doi: 10.1038/s41467-022-35199-0. PMID: 36460681; PMCID: PMC9718843.
• Dong X, Guo R, Ji T, Zhang J, Xu J, Li Y, Sheng Y, Wang Y, Fang K, Wen Y, Liu B, Hu G, Deng H, Yao H. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency. Nucleic Acids Res. 2022 Nov 28;50(21):12019-12038. doi: 10.1093/nar/gkac230. PMID: 35425987; PMCID: PMC9756953.
• Habimana JD, Mukama O, Chen G, Chen M, Amissah OB, Wang L, Liu Y, Sun Y, Li AL, Deng S, Huang J, Yan XX, Rutaganda T, Mutangana D, Wu LP, Huang R, Li Z. Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer. Biosens Bioelectron. 2023 Feb 15;222:114939. doi: 10.1016/j.bios.2022.114939. Epub 2022 Nov 20. PMID: 36459819.
• Jin Q, Yang X, Gou S, Liu X, Zhuang Z, Liang Y, Shi H, Huang J, Wu H, Zhao Y, Ouyang Z, Zhang Q, Liu Z, Chen F, Ge W, Xie J, Li N, Lai C, Zhao X, Wang J, Lian M, Li L, Quan L, Ye Y, Lai L, Wang K. Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. Sci China Life Sci. 2022 Nov;65(11):2269-2286. doi: 10.1007/s11427-021-2088-1. Epub 2022 May 18. PMID: 35596888.
• Qin L, Cui Y, Yuan T, Chen D, Zhao R, Li S, Jiang Z, Wu Q, Long Y, Wang S, Tang Z, Pan H, Li X, Wei W, Yang J, Luo X, Zhang Z, Tang Q, Liu P, Weinkove R, Yao Y, Qin D, Thiery JP, Li P. Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis. Nat Commun. 2022 Oct 13;13(1):6051. doi: 10.1038/s41467-022-33793-w. PMID: 36229619; PMCID: PMC9561169.
• He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. PMID: 36151403; PMCID: PMC9519457.
• Lai P, Chen X, Wang Y, Wang J, Zhang Y, Geng S, Li P, Du X, Weng J, Pei D. C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction. J Hematol Oncol. 2022 May 21;15(1):68. doi: 10.1186/s13045-022-01288-2. PMID: 35597971; PMCID: PMC9124432.
• Liang Y, Xie J, Zhang Q, Wang X, Gou S, Lin L, Chen T, Ge W, Zhuang Z, Lian M, Chen F, Li N, Ouyang Z, Lai C, Liu X, Li L, Ye Y, Wu H, Wang K, Lai L. AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic Acids Res. 2022 May 20;50(9):5384-5399. doi: 10.1093/nar/gkac353. PMID: 35544322; PMCID: PMC9122597.
• Yu S, Zhou C, He J, Yao Z, Huang X, Rong B, Zhu H, Wang S, Chen S, Wang X, Cai B, Zhao G, Chen Y, Xiao L, Liu H, Qin Y, Guo J, Wu H, Zhang Z, Zhang M, Zhao X, Lan F, Wang Y, Chen J, Cao S, Pei D, Liu J. BMP4 drives primed to naïve transition through PGC-like state. Nat Commun. 2022 May 19;13(1):2756. doi: 10.1038/s41467-022-30325-4. PMID: 35589713; PMCID: PMC9120449.
• Mazid MA, Ward C, Luo Z, Liu C, Li Y, Lai Y, Wu L, Li J, Jia W, Jiang Y, Liu H, Fu L, Yang Y, Ibañez DP, Lai J, Wei X, An J, Guo P, Yuan Y, Deng Q, Wang Y, Liu Y, Gao F, Wang J, Zaman S, Qin B, Wu G, Maxwell PH, Xu X, Liu L, Li W, Esteban MA. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature. 2022 May;605(7909):315-324. doi: 10.1038/s41586-022-04625-0. Epub 2022 Mar 21. PMID: 35314832.
• Habimana JD, Huang R, Muhoza B, Kalisa YN, Han X, Deng W, Li Z. Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review. Biosens Bioelectron. 2022 May 1;203:114033. doi: 10.1016/j.bios.2022.114033. Epub 2022 Jan 25. PMID: 35131696.
• Xing G, Liu Z, Huang L, Zhao D, Wang T, Yuan H, Wu Y, Li L, Long Q, Zhou Y, Hao Z, Liu Y, Lu J, Li S, Zhu J, Wang B, Wang J, Liu J, Chen J, Pei D, Liu X, Chen K. Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death Differ. 2022 Nov;29(11):2333. doi: 10.1038/s41418-021-00923-8. Erratum for: Cell Death Differ. 2022 May;29(5):1042-1054. PMID: 34893691; PMCID: PMC9613639.
• Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M, Liu X. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Sci Adv. 2022 Apr 15;8(15):eabk2376. doi: 10.1126/sciadv.abk2376. Epub 2022 Apr 13. PMID: 35417232; PMCID: PMC9007515.
• Zhang Q, Wu B, Weng Q, Hu F, Lin Y, Xia C, Peng H, Wang Y, Liu X, Liu L, Xiong J, Geng Y, Zhao Y, Zhang M, Du J, Wang J. Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors. Cell Mol Immunol. 2022 Apr;19(4):492-503. doi: 10.1038/s41423-021-00805-6. Epub 2021 Dec 10. PMID: 34893754; PMCID: PMC8975874.
• Liu Y, Zhou J, Lan T, Zhou X, Yang Y, Li C, Zhang Q, Chen M, Wei S, Zheng S, Cheng L, Zheng Y, Lai L, Zou Q. Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites. Cell Discov. 2022 Mar 23;8(1):28. doi: 10.1038/s41421-022-00384-4. PMID: 35322006; PMCID: PMC8942999.
• Wang T, Xia C, Weng Q, Wang K, Dong Y, Hao S, Dong F, Liu X, Liu L, Geng Y, Guan Y, Du J, Cheng T, Cheng H, Wang J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022 Jan 1;107(1):154-166. doi: 10.3324/haematol.2019.239186. PMID: 33299232; PMCID: PMC8719103.

所有文章

• Tang L, Dong S, Rasheed N, Wu HW, Zhou N, Li H, Wang M, Zheng J, He J, Chao WCH. Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP. Cell Rep. 2022 Dec 6;41(10):111732. doi: 10.1016/j.celrep.2022.111732. PMID: 36476863.
• Li W, Long Q, Wu H, Zhou Y, Duan L, Yuan H, Ding Y, Huang Y, Wu Y, Huang J, Liu D, Chen B, Zhang J, Qi J, Du S, Li L, Liu Y, Ruan Z, Liu Z, Liu Z, Zhao Y, Lu J, Wang J, Chan WY, Liu X. Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nat Commun. 2022 Dec 2;13(1):7414. doi: 10.1038/s41467-022-35199-0. PMID: 36460681; PMCID: PMC9718843.
• Wang X, Jin Q, Xiao W, Fang P, Lai L, Xiao S, Wang K, Fang L. Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus. J Virol. 2022 Dec 21;96(24):e0162622. doi: 10.1128/jvi.01626-22. Epub 2022 Dec 1. PMID: 36453883; PMCID: PMC9769367.
• Li E, Wang K, Zhang B, Guo S, Xiao S, Pan Q, Wang X, Chen W, Wu Y, Xu H, Kong X, Luo C, Chen S, Liu B. Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1537-1555. doi: 10.1080/14756366.2022.2079640. PMID: 35670075; PMCID: PMC9186373.
• You K, Wang Y, Chen X, Yang Z, Chen Y, Tan S, Tao J, Getachew A, Pan T, Xu Y, Zhuang Y, Yang F, Lin X, Li Y. Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury. Biochem Biophys Res Commun. 2023 Jan 8;639:20-28. doi: 10.1016/j.bbrc.2022.11.079. Epub 2022 Nov 28. PMID: 36463757.
• Dong X, Guo R, Ji T, Zhang J, Xu J, Li Y, Sheng Y, Wang Y, Fang K, Wen Y, Liu B, Hu G, Deng H, Yao H. YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency. Nucleic Acids Res. 2022 Nov 28;50(21):12019-12038. doi: 10.1093/nar/gkac230. PMID: 35425987; PMCID: PMC9756953.
• Liu Z, Chen S, Xie W, Yu H, Lai L, Li Z. Versatile and efficient genome editing with Neisseria cinerea Cas9. Commun Biol. 2022 Nov 26;5(1):1296. doi: 10.1038/s42003-022-04258-z. PMID: 36435853; PMCID: PMC9701194.
• Fan Y, Zhang Y, Shi K, Cheng S, Pei D, Shu X. Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors. Cell Death Dis. 2022 Nov 26;13(11):1000. doi: 10.1038/s41419-022-05447-8. PMID: 36435804; PMCID: PMC9701226.
• Yang Z, Huang X, Zhang J, You K, Xiong Y, Fang J, Getachew A, Cheng Z, Yu X, Wang Y, Wu F, Wang N, Feng S, Lin X, Yang F, Chen Y, Wei H, Li YX. Hepatic DKK1-driven steatosis is CD36 dependent. Life Sci Alliance. 2022 Nov 21;6(1):e202201665. doi: 10.26508/lsa.202201665. PMID: 36410795; PMCID: PMC9679335.
• Habimana JD, Mukama O, Chen G, Chen M, Amissah OB, Wang L, Liu Y, Sun Y, Li AL, Deng S, Huang J, Yan XX, Rutaganda T, Mutangana D, Wu LP, Huang R, Li Z. Harnessing enhanced CRISPR/Cas12a trans-cleavage activity with extended reporters and reductants for early diagnosis of Helicobacter pylori, the causative agent of peptic ulcers and stomach cancer. Biosens Bioelectron. 2023 Feb 15;222:114939. doi: 10.1016/j.bios.2022.114939. Epub 2022 Nov 20. PMID: 36459819.
• Jiang J, Lyu P, Li J, Huang S, Tao J, Blackshaw S, Qian J, Wang J. IReNA: Integrated regulatory network analysis of single-cell transcriptomes and chromatin accessibility profiles. iScience. 2022 Oct 14;25(11):105359. doi: 10.1016/j.isci.2022.105359. PMID: 36325073; PMCID: PMC9619378.
• Chen F, Lian M, Ma B, Gou S, Luo X, Yang K, Shi H, Xie J, Ge W, Ouyang Z, Lai C, Li N, Zhang Q, Jin Q, Liang Y, Chen T, Wang J, Zhao X, Li L, Yu M, Ye Y, Wang K, Wu H, Lai L. Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors. Commun Biol. 2022 Nov 2;5(1):1163. doi: 10.1038/s42003-022-04152-8. PMID: 36323848; PMCID: PMC9630288.
• Jin Q, Yang X, Gou S, Liu X, Zhuang Z, Liang Y, Shi H, Huang J, Wu H, Zhao Y, Ouyang Z, Zhang Q, Liu Z, Chen F, Ge W, Xie J, Li N, Lai C, Zhao X, Wang J, Lian M, Li L, Quan L, Ye Y, Lai L, Wang K. Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression. Sci China Life Sci. 2022 Nov;65(11):2269-2286. doi: 10.1007/s11427-021-2088-1. Epub 2022 May 18. PMID: 35596888.
• Chen M, Wang X, Li C, Lan T, Wei Y, Tang C, Zhou X, Zhou R, Rosa A, Zheng X, Ang S, Zhang K, Zou Q, Lai L. Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo. Cell Prolif. 2022 Nov;55(11):e13319. doi: 10.1111/cpr.13319. Epub 2022 Aug 9. PMID: 35943218; PMCID: PMC9628231.
• Qin L, Cui Y, Yuan T, Chen D, Zhao R, Li S, Jiang Z, Wu Q, Long Y, Wang S, Tang Z, Pan H, Li X, Wei W, Yang J, Luo X, Zhang Z, Tang Q, Liu P, Weinkove R, Yao Y, Qin D, Thiery JP, Li P. Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis. Nat Commun. 2022 Oct 13;13(1):6051. doi: 10.1038/s41467-022-33793-w. PMID: 36229619; PMCID: PMC9561169.
• He P, Liu B, Gao X, Yan Q, Pei R, Sun J, Chen Q, Hou R, Li Z, Zhang Y, Zhao J, Sun H, Feng B, Wang Q, Yi H, Hu P, Li P, Zhang Y, Chen Z, Niu X, Zhong X, Jin L, Liu X, Qu K, Ciazynska KA, Carter AP, Briggs JAG, Chen J, Liu J, Chen X, He J, Chen L, Xiong X. SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope. Nat Microbiol. 2022 Oct;7(10):1635-1649. doi: 10.1038/s41564-022-01235-4. Epub 2022 Sep 23. PMID: 36151403; PMCID: PMC9519457.
• Li Y, Wang H, Chen H, Liao Y, Gou S, Yan Q, Zhuang Z, Li H, Wang J, Suo Y, Lan T, Liu Y, Zhao Y, Zou Q, Nie T, Hui X, Lai L, Wu D, Fan N. Generation of a genetically modified pig model with CREBRFR457Q variant. FASEB J. 2022 Nov;36(11):e22611. doi: 10.1096/fj.202201117. PMID: 36250915.
• Zhang X, Chen L, Huang X, Chen H, Cai B, Qin Y, Chen Y, Ou S, Li X, Wu Z, Feng Z, Zeng M, Guo W, Li H, Zhou C, Yu S, Pan M, Liu J, Kang K, Cao S, Pei D. MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin. Stem Cell Rev Rep. 2022 Oct;18(7):2414-2430. doi: 10.1007/s12015-022-10339-7. Epub 2022 Mar 4. PMID: 35246800.
• Chen S, Liu Z, Yu H, Lai L, Li Z. Efficient multinucleotide deletions using deaminase-Cas9 fusions in human cells. J Genet Genomics. 2022 Oct;49(10):927-933. doi: 10.1016/j.jgg.2022.03.007. Epub 2022 Apr 11. PMID: 35421582.
• Zhao S, Liu X, Li L, Kong X, Sun W, Loomes K, Nie T, Hui X, Wu D. KIRA8 attenuates non-alcoholic steatohepatitis through inhibition of the IRE1α/XBP1 signalling pathway. Biochem Biophys Res Commun. 2022 Dec 3;632:158-164. doi: 10.1016/j.bbrc.2022.09.098. Epub 2022 Sep 29. PMID: 36209584.
• Gong S, Hu G, Guo R, Zhang J, Yang Y, Ji B, Li G, Yao H. CTCF acetylation at lysine 20 is required for the early cardiac mesoderm differentiation of embryonic stem cells. Cell Regen. 2022 Sep 19;11(1):34. doi: 10.1186/s13619-022-00131-w. PMID: 36117192; PMCID: PMC9482892.
• Wang L, Zhang H, Lv P, Li Y, Teng M, Liu Y, Wu D. Structural Insights into Mouse H-FABP. Life (Basel). 2022 Sep 16;12(9):1445. doi: 10.3390/life12091445. PMID: 36143481; PMCID: PMC9505153.
• Wang W, Lu J, Song Y, Zeng C, Wang Y, Yang C, Huang B, Dai Y, Yang J, Lai L, Wang L, Cai D, Bai X. Repair of bone defects in rhesus monkeys with α1,3-galactosyltransferase-knockout pig cancellous bone. Front Bioeng Biotechnol. 2022 Sep 12;10:990769. doi: 10.3389/fbioe.2022.990769. PMID: 36172016; PMCID: PMC9510634.
• Deng ZH, Zhong J, Jiang HL, Jeong HW, Chen JW, Shu YH, Tan M, Adams RH, Xie KP, Chen Q, Liu Y. Antipsychotic drugs induce vascular defects in hematopoietic organs. FASEB J. 2022 Oct;36(10):e22538. doi: 10.1096/fj.202200862R. Erratum in: FASEB J. 2022 Nov;36(11):e22636. PMID: 36065631.
• Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. Nat Commun. 2022 Sep 5;13(1):5208. doi: 10.1038/s41467-022-32871-3. PMID: 36064857; PMCID: PMC9445001.
• Li P, Liu Y, Cheng Z, Yu X, Li Y. COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment management. Biomed Pharmacother. 2022 Oct;154:113568. doi: 10.1016/j.biopha.2022.113568. Epub 2022 Aug 17. PMID: 36029543; PMCID: PMC9381432.
• Wu H, Li C, Masood M, Zhang Z, González-Almela E, Castells-Garcia A, Zou G, Xu X, Wang L, Zhao G, Yu S, Zhu P, Wang B, Qin D, Liu J. Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation. Cells. 2022 Aug 8;11(15):2460. doi: 10.3390/cells11152460. PMID: 35954307; PMCID: PMC9368660.
• Li L, Wan Q, Long Q, Nie T, Zhao S, Mao L, Cheng C, Zou C, Loomes K, Xu A, Lai L, Liu X, Duan Z, Hui X, Wu D. Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions. Adipocyte. 2022 Dec;11(1):529-549. doi: 10.1080/21623945.2022.2111053. PMID: 36000239; PMCID: PMC9427046.
• Cheng Z, Guo D, Ruzi A, Pan T, You K, Chen Y, Huang X, Zhang J, Yang F, Niu L, Xu K, Li YX. Modeling MEN1 with Patient-Origin iPSCs Reveals GLP-1R Mediated Hypersecretion of Insulin. Cells. 2022 Aug 3;11(15):2387. doi: 10.3390/cells11152387. PMID: 35954231; PMCID: PMC9368616.
• Huang R, Li S, Tian C, Zhou P, Zhao H, Xie W, Xiao J, Wang L, Habimana JD, Lin Z, Yang Y, Cheng N, Li Z. Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma. Br J Cancer. 2022 Nov;127(8):1424-1439. doi: 10.1038/s41416-022-01896-2. Epub 2022 Jul 27. PMID: 35896815; PMCID: PMC9553907.
• 郭彦，杨乐乐，戚华宇.小鼠雄性生殖干细胞转录组分析揭示成熟精原干细胞特征.遗传.2022 年 7 月, 44(7): 591―608.
• Han X, de Dieu Habimana J, Li AL, Huang R, Mukama O, Deng W, Wang L, Zhang Y, Wang W, Deng S, Peng K, Ni B, Zhang S, Huang J, Yan XX, Li Z. Correction: Transcription factor EB-mediated mesenchymal stem cell therapy induces autophagy and alleviates spinocerebellar ataxia type 3 defects in neuronal cells model. Cell Death Dis. 2022 Jul 28;13(7):654. doi: 10.1038/s41419-022-05119-7. Erratum for: Cell Death Dis. 2022 Jul 18;13(7):622. PMID: 35902560; PMCID: PMC9334382.
• Zhou J, Liu Y, Wei Y, Zheng S, Gou S, Chen T, Yang Y, Lan T, Chen M, Liao Y, Zhang Q, Tang C, Liu Y, Wu Y, Peng X, Gao M, Wang J, Zhang K, Lai L, Zou Q. Eliminating predictable DNA off-target effects of cytosine base editor by using dual guiders including sgRNA and TALE. Mol Ther. 2022 Jul 6;30(7):2443-2451. doi: 10.1016/j.ymthe.2022.04.010. Epub 2022 Apr 20. PMID: 35443934; PMCID: PMC9263286.
• Xin Y, Lyu P, Jiang J, Zhou F, Wang J, Blackshaw S, Qian J. LRLoop: a method to predict feedback loops in cell-cell communication. Bioinformatics. 2022 Sep 2;38(17):4117-4126. doi: 10.1093/bioinformatics/btac447. PMID: 35788263; PMCID: PMC9438954.
• Zhang Y, Deng W, Wang W, Song A, Mukama O, Deng S, Han X, De Dieu Habimana J, Peng K, Ni B, Zhang S, Huang J, Yan XX, Li Z. MicroRNA-206 down-regulated human umbilical cord mesenchymal stem cells alleviate cognitive decline in D-galactose-induced aging mice. Cell Death Discov. 2022 Jul 4;8(1):304. doi: 10.1038/s41420-022-01097-z. PMID: 35781287; PMCID: PMC9250929.
• Zhang D, Zhou M, Zhang Y, Shan Y, Pan G. Generation of an RNF1-deficient human pluripotent stem cell line using CRISPR/Cas9 technology. Stem Cell Res. 2022 Jul;62:102809. doi: 10.1016/j.scr.2022.102809. Epub 2022 May 8. PMID: 35567848.
• Zhang J, Zhou T, Shan Y, Pan G. Generation of RYBP FLAG-HA knock-in human embryonic stem cell line through CRISPR/Cas9-mediated homologous recombination. Stem Cell Res. 2022 Jul;62:102803. doi: 10.1016/j.scr.2022.102803. Epub 2022 May 4. PMID: 35537243.
• Chen S, Liu Z, Xie W, Yu H, Lai L, Li Z. Compact Cje3Cas9 for Efficient In Vivo Genome Editing and Adenine Base Editing. CRISPR J. 2022 Jun;5(3):472-486. doi: 10.1089/crispr.2021.0143. PMID: 35686977.
• Tao J, Chen Y, Zhuang Y, Wei R, Getachew A, Pan T, Yang F, Li Y. Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle. Curr Issues Mol Biol. 2022 Jan 18;44(2):470-482. doi: 10.3390/cimb44020032. PMID: 35723318; PMCID: PMC8928988.
• Lin R, Zhai Z, Kuang J, Wu C, Yao Y, Shi R, He J, Xu S, Li P, Fan Y, Li W, Wu Z, Li X, Ming J, Guo J, Wang B, Li D, Cao S, Zhang X, Li Y, Pei D, Liu J. H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition. Cell Biosci. 2022 Jun 16;12(1):89. doi: 10.1186/s13578-022-00827-1. PMID: 35710570; PMCID: PMC9204951.
• Jiang Z, Cheng L, Wu Z, Zhou L, Wang H, Hong Q, Wu Q, Long Y, Huang Y, Xu G, Yao Y, Tang Z, Zhang Z, Yang L, Luo W, Yang J, Gong L, Liu P, Chen X, Cui S, Zhang Q, Li Y, Li P. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors. EMBO Rep. 2022 Jun 7;23(6):e54275. doi: 10.15252/embr.202154275. Epub 2022 Apr 19. PMID: 35437924; PMCID: PMC9171684.
• Li S, Zhao R, Zheng D, Qin L, Cui Y, Li Y, Jiang Z, Zhong M, Shi J, Li M, Wang X, Tang Z, Wu Q, Long Y, Hu D, Wang S, Yao Y, Liu S, Yang LH, Zhang Z, Tang Q, Liu P, Li Y, Li P. DAP10 integration in CAR-T cells enhances the killing of heterogeneous tumors by harnessing endogenous NKG2D. Mol Ther Oncolytics. 2022 Jun 6;26:15-26. doi: 10.1016/j.omto.2022.06.003. PMID: 35784403; PMCID: PMC9218287.
• Chen S, Liu Z, Lai L, Li Z. Efficient C-to-G Base Editing with Improved Target Compatibility Using Engineered Deaminase-nCas9 Fusions. CRISPR J. 2022 Jun;5(3):389-396. doi: 10.1089/crispr.2021.0124. Epub 2022 Mar 2. PMID: 35238619.
• Huang D, Zhao Q, Zhang M, Weng Q, Zhang Q, Wang K, Dong F, Cheng H, Hu F, Wang J. Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells. Cell Prolif. 2022 Jun;55(6):e13235. doi: 10.1111/cpr.13235. Epub 2022 May 17. PMID: 35582777; PMCID: PMC9201374.
• Zheng D, Wang X, Cheng L, Qin L, Jiang Z, Zhao R, Li Y, Shi J, Wu Q, Long Y, Wang S, Tang Z, Wei W, Yang J, Li Y, Zhou H, Liu Q, Liu P, Chen X, Yao Y, Yang L, Li P. The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies. Front Immunol. 2022 May 26;13:808347. doi: 10.3389/fimmu.2022.808347. PMID: 35693763; PMCID: PMC9182403.
• Lai P, Chen X, Wang Y, Wang J, Zhang Y, Geng S, Li P, Du X, Weng J, Pei D. C3aR costimulation enhances the antitumor efficacy of CAR-T cell therapy through Th17 expansion and memory T cell induction. J Hematol Oncol. 2022 May 21;15(1):68. doi: 10.1186/s13045-022-01288-2. PMID: 35597971; PMCID: PMC9124432.
• Liang Y, Xie J, Zhang Q, Wang X, Gou S, Lin L, Chen T, Ge W, Zhuang Z, Lian M, Chen F, Li N, Ouyang Z, Lai C, Liu X, Li L, Ye Y, Wu H, Wang K, Lai L. AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns. Nucleic Acids Res. 2022 May 20;50(9):5384-5399. doi: 10.1093/nar/gkac353. PMID: 35544322; PMCID: PMC9122597.
• Lan T, Zheng Y, Suo Y, Wei Y, Shi H, Yan Q, Zhuang Z, Chen H, Zhang Q, Fan N, Zhao Y, Ouyang Z, Lai C, Liu Z, Zhou J, Tang C, Kim NH, Zou Q, Wang X. Generation of pigs with humanized type II collagen by precise human COL2A1 gene knock-in. J Genet Genomics. 2022 May 19:S1673-8527(22)00139-4. doi: 10.1016/j.jgg.2022.05.001. Epub ahead of print. PMID: 35598861.
• Yu S, Zhou C, He J, Yao Z, Huang X, Rong B, Zhu H, Wang S, Chen S, Wang X, Cai B, Zhao G, Chen Y, Xiao L, Liu H, Qin Y, Guo J, Wu H, Zhang Z, Zhang M, Zhao X, Lan F, Wang Y, Chen J, Cao S, Pei D, Liu J. BMP4 drives primed to naïve transition through PGC-like state. Nat Commun. 2022 May 19;13(1):2756. doi: 10.1038/s41467-022-30325-4. PMID: 35589713; PMCID: PMC9120449.
• Zou Q, Yang L, Qi H. Protocol for isolation and proteostatic analysis of sub-populations of spermatogenic cells in mouse. STAR Protoc. 2022 May 14;3(2):101398. doi: 10.1016/j.xpro.2022.101398. PMID: 35600921; PMCID: PMC9117932.
• Chen, A., Liao, S., Cheng, M., Ma, K., Wu, L., Lai, Y., Qiu, X., Yang, J., Xu, J., Hao, S., Wang, X., Lu, H., Chen, X., Liu, X., Huang, X., Li, Z., Hong, Y., Jiang, Y., Peng, J., Liu, S., … Wang, J. (2022). Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell, 185(10), 1777–1792.e21. https://doi.org/10.1016/j.cell.2022.04.003
• Zhu Y, Zhang Z, Fan N, Huang K, Li H, Gu J, Zhang Q, Ouyang Z, Zhang T, Tang J, Zhang Y, Suo Y, Lai C, Wang J, Wang J, Shan Y, Wang M, Chen Q, Zhou T, Lai L, Pan G. Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells. Stem Cell Reports. 2022 May 10;17(5):1059-1069. doi: 10.1016/j.stemcr.2022.03.009. Epub 2022 Apr 14. PMID: 35427483; PMCID: PMC9133581.
• Sun D, Gan X, Liu L, Yang Y, Ding D, Li W, Jiang J, Ding W, Zhao L, Hou G, Yu J, Wang J, Yang F, Yuan S, Zhou W. DNA hypermethylation modification promotes the development of hepatocellular carcinoma by depressing the tumor suppressor gene ZNF334. Cell Death Dis. 2022 May 9;13(5):446. doi: 10.1038/s41419-022-04895-6. PMID: 35534462; PMCID: PMC9085879.
• Habimana JD, Huang R, Muhoza B, Kalisa YN, Han X, Deng W, Li Z. Mechanistic insights of CRISPR/Cas nucleases for programmable targeting and early-stage diagnosis: A review. Biosens Bioelectron. 2022 May 1;203:114033. doi: 10.1016/j.bios.2022.114033. Epub 2022 Jan 25. PMID: 35131696.
• Mazid MA, Ward C, Luo Z, Liu C, Li Y, Lai Y, Wu L, Li J, Jia W, Jiang Y, Liu H, Fu L, Yang Y, Ibañez DP, Lai J, Wei X, An J, Guo P, Yuan Y, Deng Q, Wang Y, Liu Y, Gao F, Wang J, Zaman S, Qin B, Wu G, Maxwell PH, Xu X, Liu L, Li W, Esteban MA. Rolling back human pluripotent stem cells to an eight-cell embryo-like stage. Nature. 2022 May;605(7909):315-324. doi: 10.1038/s41586-022-04625-0. Epub 2022 Mar 21. PMID: 35314832.
• Xing G, Liu Z, Huang L, Zhao D, Wang T, Yuan H, Wu Y, Li L, Long Q, Zhou Y, Hao Z, Liu Y, Lu J, Li S, Zhu J, Wang B, Wang J, Liu J, Chen J, Pei D, Liu X, Chen K. Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death Differ. 2022 Nov;29(11):2333. doi: 10.1038/s41418-021-00923-8. Erratum for: Cell Death Differ. 2022 May;29(5):1042-1054. PMID: 34893691; PMCID: PMC9613639.
• Kang B, Zhang T, Huang K, Wang T, Li Y, Mai Y, Li J, Dang S, Zhang Z, Huang W, Wang J, Gao M, Wang Y, Pan G. GFI1 regulates chromatin state essential in human endothelial-to-haematopoietic transition. Cell Prolif. 2022 May;55(5):e13244. doi: 10.1111/cpr.13244. Epub 2022 May 3. PMID: 35504619; PMCID: PMC9136496.
• Long B, Shan Y, Sun Y, Wang T, Li X, Huang K, Zhang W, He Y, Wen R, Li Y, Mai Y, Feng Y, Zhang T, Kang B, Zhang C, Zhu Y, Gu J, Liu J, Zhang X, Pan G. Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia. Biochim Biophys Acta Mol Basis Dis. 2022 May 1;1868(5):166357. doi: 10.1016/j.bbadis.2022.166357. Epub 2022 Feb 7. PMID: 35143932.
• Bao F, Zhou L, Zhou R, Huang Q, Chen J, Zeng S, Wu Y, Yang L, Qian S, Wang M, He X, Liang S, Qi J, Xiang G, Long Q, Guo J, Ying Z, Zhou Y, Zhao Q, Zhang J, Zhang D, Sun W, Gao M, Wu H, Zhao Y, Nie J, Li M, Chen Q, Chen J, Zhang X, Pan G, Zhang H, Li M, Tian M, Liu X. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Sci Adv. 2022 Apr 15;8(15):eabk2376. doi: 10.1126/sciadv.abk2376. Epub 2022 Apr 13. PMID: 35417232; PMCID: PMC9007515.
• Han, L., Wei, X., Liu, C., Volpe, G., Zhuang, Z., Zou, X., Wang, Z., Pan, T., Yuan, Y., Zhang, X., Fan, P., Guo, P., Lai, Y., Lei, Y., Liu, X., Yu, F., Shangguan, S., Lai, G., Deng, Q., Liu, Y., … Liu, L. (2022). Cell transcriptomic atlas of the non-human primate Macaca fascicularis. Nature, 604(7907), 723–731. https://doi.org/10.1038/s41586-022-04587-3
• Pan T, Wang N, Zhang J, Yang F, Chen Y, Zhuang Y, Xu Y, Fang J, You K, Lin X, Li Y, Li S, Liang K, Li YX, Gao Y. Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy. Stem Cell Res Ther. 2022 Apr 11;13(1):159. doi: 10.1186/s13287-022-02831-1. PMID: 35410439; PMCID: PMC8996222.
• Song Y, Liang Z, Zhang J, Hu G, Wang J, Li Y, Guo R, Dong X, Babarinde IA, Ping W, Sheng YL, Li H, Chen Z, Gao M, Chen Y, Shan G, Zhang MQ, Hutchins AP, Fu XD, Yao H. CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming. Cell Rep. 2022 Apr 5;39(1):110626. doi: 10.1016/j.celrep.2022.110626. PMID: 35385732.
• Zhang Q, Wu B, Weng Q, Hu F, Lin Y, Xia C, Peng H, Wang Y, Liu X, Liu L, Xiong J, Geng Y, Zhao Y, Zhang M, Du J, Wang J. Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors. Cell Mol Immunol. 2022 Apr;19(4):492-503. doi: 10.1038/s41423-021-00805-6. Epub 2021 Dec 10. PMID: 34893754; PMCID: PMC8975874.
• Jiang Z, Qin L, Tang Y, Liao R, Shi J, He B, Li S, Zheng D, Cui Y, Wu Q, Long Y, Yao Y, Wei Z, Hong Q, Wu Y, Mai Y, Gou S, Li X, Weinkove R, Norton S, Luo W, Feng W, Zhou H, Liu Q, Chen J, Lai L, Chen X, Pei D, Graf T, Liu X, Li Y, Liu P, Zhang Z, Li P. Human induced-T-to-natural killer cells have potent anti-tumour activities. Biomark Res. 2022 Mar 24;10(1):13. doi: 10.1186/s40364-022-00358-4. PMID: 35331335; PMCID: PMC8943975.
• Liu Y, Zhou J, Lan T, Zhou X, Yang Y, Li C, Zhang Q, Chen M, Wei S, Zheng S, Cheng L, Zheng Y, Lai L, Zou Q. Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites. Cell Discov. 2022 Mar 23;8(1):28. doi: 10.1038/s41421-022-00384-4. PMID: 35322006; PMCID: PMC8942999.
• Chen M, Sui T, Yang L, Qian Y, Liu Z, Liu Y, Wang G, Lai L, Li Z. Live imaging of RNA and RNA splicing in mammalian cells via the dcas13a-SunTag-BiFC system. Biosens Bioelectron. 2022 May 15;204:114074. doi: 10.1016/j.bios.2022.114074. Epub 2022 Feb 4. PMID: 35149451.
• Liu Y, Chen Q, Jeong HW, Koh BI, Watson EC, Xu C, Stehling M, Zhou B, Adams RH. A specialized bone marrow microenvironment for fetal haematopoiesis. Nat Commun. 2022 Mar 14;13(1):1327. doi: 10.1038/s41467-022-28775-x. PMID: 35288551; PMCID: PMC8921288.
• Lu J, Fan W, Huang Z, Fan K, Dong J, Qin J, Luo J, Zhang Z, Sun G, Duan C, Pan K, Gu W, Zhang X. Automatic system for high-throughput and high-sensitivity diagnosis of SARS-CoV-2. Bioprocess Biosyst Eng. 2022 Mar;45(3):503-514. doi: 10.1007/s00449-021-02674-9. Epub 2022 Jan 15. PMID: 35031864; PMCID: PMC8760113.
• Wu R, Guo Y, Zhang L, Zheng H, Chen X, Li M, Xing Q, Huang W, Su Z, Zhang D, Zhong X, Pan G, Hu X. Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model. Stem Cell Reports. 2022 Feb 8;17(2):276-288. doi: 10.1016/j.stemcr.2021.12.006. Epub 2022 Jan 13. PMID: 35030322; PMCID: PMC8828662.
• Zhao H, Li S, He L, Tang F, Han X, Deng W, Lin Z, Huang R, Li Z. Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome. Mol Neurobiol. 2022 Feb;59(2):748-761. doi: 10.1007/s12035-021-02633-1. Epub 2021 Nov 11. PMID: 34766239.
• Xu X, Ahmed T, Wang L, Cao X, Zhang Z, Wang M, Lv Y, Kanwal S, Tariq M, Lin R, Zhang H, Huang Y, Peng H, Lin D, Shi X, Geng D, Liu B, Zhang X, Yi W, Qin Y, Esteban MA, Qin B. The mTORC1-eIF4F axis controls paused pluripotency. EMBO Rep. 2022 Feb 3;23(2):e53081. doi: 10.15252/embr.202153081. Epub 2021 Dec 6. PMID: 34866316; PMCID: PMC8811634.
• Liu Z, Chen S, Lai L, Li Z. Inhibition of base editors with anti-deaminases derived from viruses. Nat Commun. 2022 Feb 1;13(1):597. doi: 10.1038/s41467-022-28300-0. PMID: 35105899; PMCID: PMC8807840.
• Liu Y, Yang Y, Suo Y, Li C, Chen M, Zheng S, Li H, Tang C, Fan N, Lan T, Zhou J, Li Y, Wang J, Chen H, Zou Q, Lai L. Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy. Mol Ther Methods Clin Dev. 2022 Feb 1;24:332-341. doi: 10.1016/j.omtm.2022.01.014. PMID: 35229007; PMCID: PMC8851157.
• Zhao D, Qian Y, Li J, Li Z, Lai L. Highly efficient A-to-G base editing by ABE8.17 in rabbits. Mol Ther Nucleic Acids. 2022 Jan 28;27:1156-1163. doi: 10.1016/j.omtn.2022.01.019. PMID: 35282412; PMCID: PMC8888895.
• Liu Z, Chen S, Xie W, Song Y, Li J, Lai L, Li Z. Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9. Mol Ther. 2022 Jan 5;30(1):256-267. doi: 10.1016/j.ymthe.2021.06.013. Epub 2021 Jun 24. PMID: 34174445; PMCID: PMC8753289.
• Wang T, Xia C, Weng Q, Wang K, Dong Y, Hao S, Dong F, Liu X, Liu L, Geng Y, Guan Y, Du J, Cheng T, Cheng H, Wang J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica. 2022 Jan 1;107(1):154-166. doi: 10.3324/haematol.2019.239186. PMID: 33299232; PMCID: PMC8719103.

重要文章

• Castells-Garcia A, Ed-Daoui I, González-Almela E, Vicario C, Ottestrom J, Lakadamyali M, Neguembor MV, Cosma MP. Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches. Nucleic Acids Res. 2022 Jan 11;50(1):175-190. doi: 10.1093/nar/gkab1215. PMID: 34929735; PMCID: PMC8754629.
• Zhang Q, Wu B, Weng Q, Hu F, Lin Y, Xia C, Peng H, Wang Y, Liu X, Liu L, Xiong J, Geng Y, Zhao Y, Zhang M, Du J, Wang J. Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors. Cell Mol Immunol. 2021 Dec 10. doi: 10.1038/s41423-021-00805-6. Epub ahead of print. PMID: 34893754.
• Xing G, Liu Z, Huang L, Zhao D, Wang T, Yuan H, Wu Y, Li L, Long Q, Zhou Y, Hao Z, Liu Y, Lu J, Li S, Zhu J, Wang B, Wang J, Liu J, Chen J, Pei D, Liu X, Chen K. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death Differ. 2021 Nov 24. doi: 10.1038/s41418-021-00902-z. Epub ahead of print. Erratum in: Cell Death Differ. 2021 Dec 10;: PMID: 34815549.
• Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan WY, Liu J, Chen Y, Li P, Liu X. Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nat Struct Mol Biol. 2021 Nov;28(11):900-908. doi: 10.1038/s41594-021-00671-w. Epub 2021 Oct 28. Erratum in: Nat Struct Mol Biol. 2021 Dec;28(12):1050. PMID: 34711968.
• Guo X, Tariq M, Lai Y, Kanwal S, Lv Y, Wang X, Li N, Jiang M, Meng J, Hu J, Yuan J, Luo Z, Ward C, Volpe G, Wang D, Yin M, Qin B, Zhang B, Bao X, Esteban MA. Capture of the newly transcribed RNA interactome using click chemistry. Nat Protoc. 2021 Nov;16(11):5193-5219. doi: 10.1038/s41596-021-00609-y. Epub 2021 Oct 25. PMID: 34697467.
• Wang X, Liang Y, Zhao J, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J, Lai L. Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing. Cell Discov. 2021 Oct 12;7(1):92. doi: 10.1038/s41421-021-00304-y. Erratum in: Cell Discov. 2021 Dec 9;7(1):120. PMID: 34635647; PMCID: PMC8505425.
• Feng C, Shi J, Fan Q, Wang Y, Huang H, Chen F, Tang G, Li Y, Li P, Li J, Cui J, Guo L, Chen S, Jiang M, Feng L, Chen L, Lei C, Ke C, Deng X, Hu F, Tang X, Li F. Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery. Nat Commun. 2021 Aug 17;12(1):4984. doi: 10.1038/s41467-021-25312-0. PMID: 34404803; PMCID: PMC8370972.
• Pang N, Shi J, Qin L, Chen A, Tang Y, Yang H, Huang Y, Wu Q, Li X, He B, Li T, Liang B, Zhang J, Cao B, Liu M, Feng Y, Ye X, Chen X, Wang L, Tian Y, Li H, Li J, Hu H, He J, Hu Y, Zhi C, Tang Z, Gong Y, Xu F, Xu L, Fan W, Zhao M, Chen D, Lian H, Yang L, Li P, Zhang Z. IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin. J Hematol Oncol. 2021 Jul 29;14(1):118. doi: 10.1186/s13045-021-01128-9. PMID: 34325726; PMCID: PMC8323212.
• Qian Y, Zhao D, Sui T, Chen M, Liu Z, Liu H, Zhang T, Chen S, Lai L, Li Z. Efficient and precise generation of Tay-Sachs disease model in rabbit by prime editing system. Cell Discov. 2021 Jul 6;7(1):50. doi: 10.1038/s41421-021-00276-z. PMID: 34230459; PMCID: PMC8260710.
• Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D. SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021 Jul 2;12(1):4090. doi: 10.1038/s41467-021-24373-5. PMID: 34215745; PMCID: PMC8253816.
• Liu Z, Chen S, Xie W, Song Y, Li J, Lai L, Li Z. Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9. Mol Ther. 2022 Jan 5;30(1):256-267. doi: 10.1016/j.ymthe.2021.06.013. Epub 2021 Jun 24. PMID: 34174445; PMCID: PMC8753289.
• Jiang Z, Liao R, Lv J, Li S, Zheng D, Qin L, Wu D, Chen S, Long Y, Wu Q, Wang S, Lin S, Huang X, Tang Z, Shi P, Zhou H, Liu Q, Zhao R, Li Y, Jie Y, Wei W, Lai P, Du X, Cui S, Weinkove R, Liu P, Pei D, Yao Y, Li P. IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells. Leukemia. 2021 May;35(5):1380-1391. doi: 10.1038/s41375-020-01085-1. Epub 2020 Nov 9. PMID: 33168950.
• Chen M, Shi H, Gou S, Wang X, Li L, Jin Q, Wu H, Zhang H, Li Y, Wang L, Li H, Lin J, Guo W, Jiang Z, Yang X, Xu A, Zhu Y, Zhang C, Lai L, Li X. In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers. Genome Med. 2021 Apr 12;13(1):57. doi: 10.1186/s13073-021-00876-0. PMID: 33845891; PMCID: PMC8042958.
• Guo J, Duan L, He X, Li S, Wu Y, Xiang G, Bao F, Yang L, Shi H, Gao M, Zheng L, Hu H, Liu X. A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. Advanced Science. 2021 Mar 8;8(10):2004680. doi: 10.1002/advs.202004680. PMID: 34026460; PMCID: PMC8132052.
• He J, Babarinde IA, Sun L, Xu S, Chen R, Shi J, Wei Y, Li Y, Ma G, Zhuang Q, Hutchins AP, Chen J. Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE. Nature Communications. 2021 Mar 5;12(1):1456. doi: 10.1038/s41467-021-21808-x. PMID: 33674594; PMCID: PMC7935913.
• Li N, Gou S, Wang J, Zhang Q, Huang X, Xie J, Li L, Jin Q, Ouyang Z, Chen F, Ge W, Shi H, Liang Y, Zhuang Z, Zhao X, Lian M, Ye Y, Quan L, Wu H, Lai L, Wang K. CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I. Mol Ther. 2021 Mar 3;29(3):1001-1015. doi: 10.1016/j.ymthe.2020.11.023. Epub 2020 Nov 20. PMID: 33221434; PMCID: PMC7934638.
• Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature. 2021 Mar;591(7849):322-326. doi: 10.1038/s41586-021-03313-9. Epub 2021 Mar 3. PMID: 33658714.
• Lv C, Chen S, Hu F, Huang D, Wang T, Du J, Wang J, Wu H. Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo. Cell Mol Immunol. 2021 Mar;18(3):773-775. doi: 10.1038/s41423-020-0429-4. Epub 2020 Jun 15. PMID: 32541834; PMCID: PMC8027670.
• Liu FL, Wu K, Sun J, Duan Z, Quan X, Kuang J, Chu S, Pang W, Gao H, Xu L, Li YC, Zhang HL, Wang XH, Luo RH, Feng XL, Schöler HR, Chen X, Pei D, Wu G, Zheng YT, Chen J. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. Natl Sci Rev. 2020 Nov 24;8(2):nwaa285. doi: 10.1093/nsr/nwaa285. PMID: 34676093; PMCID: PMC7717373.

所有文章

• Castells-Garcia A, Ed-Daoui I, González-Almela E, Vicario C, Ottestrom J, Lakadamyali M, Neguembor MV, Cosma MP. Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches. Nucleic Acids Res. 2022 Jan 11;50(1):175-190. doi: 10.1093/nar/gkab1215. PMID: 34929735; PMCID: PMC8754629.
• Zhang Q, Wu B, Weng Q, Hu F, Lin Y, Xia C, Peng H, Wang Y, Liu X, Liu L, Xiong J, Geng Y, Zhao Y, Zhang M, Du J, Wang J. Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors. Cell Mol Immunol. 2021 Dec 10. doi: 10.1038/s41423-021-00805-6. Epub ahead of print. PMID: 34893754.
• Xu X, Ahmed T, Wang L, Cao X, Zhang Z, Wang M, Lv Y, Kanwal S, Tariq M, Lin R, Zhang H, Huang Y, Peng H, Lin D, Shi X, Geng D, Liu B, Zhang X, Yi W, Qin Y, Esteban MA, Qin B. The mTORC1-eIF4F axis controls paused pluripotency. EMBO Rep. 2022 Feb 3;23(2):e53081. doi: 10.15252/embr.202153081. Epub 2021 Dec 6. PMID: 34866316.
• Huang P, Zhu J, Liu Y, Liu G, Zhang R, Li D, Pei D, Zhu P. Identification of New Transcription Factors that Can Promote Pluripotent Reprogramming. Stem Cell Rev Rep. 2021 Dec;17(6):2223-2234. doi: 10.1007/s12015-021-10220-z. Epub 2021 Aug 26. PMID: 34448118; PMCID: PMC8599342.
• Shi K, Yang L, Zhuang X, Zhang L, Qi H. Yeast Two-Hybrid Screen Identifies PKA-Riα Interacting Proteins during Mouse Spermiogenesis. Genes (Basel). 2021 Nov 30;12(12):1941. doi: 10.3390/genes12121941. PMID: 34946890; PMCID: PMC8700991.
• Xing G, Liu Z, Huang L, Zhao D, Wang T, Yuan H, Wu Y, Li L, Long Q, Zhou Y, Hao Z, Liu Y, Lu J, Li S, Zhu J, Wang B, Wang J, Liu J, Chen J, Pei D, Liu X, Chen K. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death Differ. 2021 Nov 24. doi: 10.1038/s41418-021-00902-z. Epub ahead of print. Erratum in: Cell Death Differ. 2021 Dec 10;: PMID: 34815549.
• Zhao H, Li S, He L, Tang F, Han X, Deng W, Lin Z, Huang R, Li Z. Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome. Mol Neurobiol. 2021 Nov 11. doi: 10.1007/s12035-021-02633-1. Epub ahead of print. PMID: 34766239.
• Shi R, Feng Z, Zhang X. Integrative Multi-omics Landscape of Non-structural Protein 3 of Severe Acute Respiratory Syndrome Coronaviruses. Genomics Proteomics Bioinformatics. 2021 Nov 10:S1672-0229(21)00241-2. doi: 10.1016/j.gpb.2021.09.007. Epub ahead of print. PMID: 34774773; PMCID: PMC8578027.
• Cheng L, Zhou X, Zheng Y, Tang C, Liu Y, Zheng S, Liu Y, Zhou J, Li C, Chen M, Lai L, Zou Q. Simple and Rapid Assembly of TALE Modules Based on the Degeneracy of the Codons and Trimer Repeats. Genes (Basel). 2021 Nov 5;12(11):1761. doi: 10.3390/genes12111761. PMID: 34828367; PMCID: PMC8621181.
• Getachew A, Hussain M, Huang X, Li Y. Toll-like receptor 2 signaling in liver pathophysiology. Life Sci. 2021 Nov 1;284:119941. doi: 10.1016/j.lfs.2021.119941. Epub 2021 Sep 8. PMID: 34508761.
• Wei R, Yang J, Cheng CW, Ho WI, Li N, Hu Y, Hong X, Fu J, Yang B, Liu Y, Jiang L, Lai WH, Au KW, Tsang WL, Tse YL, Ng KM, Esteban MA, Tse HF. CRISPR-targeted genome editing of human induced pluripotent stem cell-derived hepatocytes for the treatment of Wilson's disease. JHEP Rep. 2021 Oct 30;4(1):100389. doi: 10.1016/j.jhepr.2021.100389. PMID: 34877514; PMCID: PMC8633686.
• Zou Q, Yang L, Shi R, Qi Y, Zhang X, Qi H. Proteostasis regulated by testis-specific ribosomal protein RPL39L maintains mouse spermatogenesis. iScience. 2021 Oct 30;24(12):103396. doi: 10.1016/j.isci.2021.103396. PMID: 34825148; PMCID: PMC8605100.
• Long Q, Zhou Y, Wu H, Du S, Hu M, Qi J, Li W, Guo J, Wu Y, Yang L, Xiang G, Wang L, Ye S, Wen J, Mao H, Wang J, Zhao H, Chan WY, Liu J, Chen Y, Li P, Liu X. Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nat Struct Mol Biol. 2021 Nov;28(11):900-908. doi: 10.1038/s41594-021-00671-w. Epub 2021 Oct 28. Erratum in: Nat Struct Mol Biol. 2021 Dec;28(12):1050. PMID: 34711968.
• Yin M, Cheng M, Liu C, Wu K, Xiong W, Fang J, Li Y, Zhang B. HNRNPA2B1 as a trigger of RNA switch modulates the miRNA-mediated regulation of CDK6. iScience. 2021 Oct 25;24(11):103345. doi: 10.1016/j.isci.2021.103345. PMID: 34805798; PMCID: PMC8590077.
• Guo X, Tariq M, Lai Y, Kanwal S, Lv Y, Wang X, Li N, Jiang M, Meng J, Hu J, Yuan J, Luo Z, Ward C, Volpe G, Wang D, Yin M, Qin B, Zhang B, Bao X, Esteban MA. Capture of the newly transcribed RNA interactome using click chemistry. Nat Protoc. 2021 Nov;16(11):5193-5219. doi: 10.1038/s41596-021-00609-y. Epub 2021 Oct 25. PMID: 34697467.
• Zhao H, Zhao J, Wu D, Sun Z, Hua Y, Zheng M, Liu Y, Yang Q, Huang X, Li Y, Piao Y, Wang Y, Lam SM, Xu H, Shui G, Wang Y, Yao H, Lai L, Du Z, Mi J, Liu E, Ji X, Zhang YQ. Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications. Sci China Life Sci. 2021 Oct 21. doi: 10.1007/s11427-021-2006-y. Epub ahead of print. PMID: 34705220.
• Sun W, Nie T, Li K, Wu W, Long Q, Feng T, Mao L, Gao Y, Liu Q, Gao X, Ye D, Yan K, Gu P, Xu Y, Zhao X, Chen K, Loomes KM, Lin S, Wu D, Hui X. Hepatic CPT1A Facilitates Liver-Adipose Cross-Talk via Induction of FGF21 in Mice. Diabetes. 2021 Oct 21:db210363. doi: 10.2337/db21-0363. Epub ahead of print. PMID: 34675003.
• Deng W, Zhang Y, Wang W, Song A, Mukama O, Huang J, Han X, Deng S, Lin Z, Habimana JDD, Huang R, Peng K, Ni B, Zhang S, Yan X, Li J, Wu LP, Li Z. Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle. Stem Cell Res Ther. 2021 Oct 21;12(1):548. doi: 10.1186/s13287-021-02614-0. PMID: 34674748; PMCID: PMC8532319.
• Wang H, Huang Q, Xia J, Cheng S, Pei D, Zhang X, Shu X. The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis. Mol Cancer Res. 2022 Feb;20(2):253-264. doi: 10.1158/1541-7786.MCR-21-0342. Epub 2021 Oct 20. PMID: 34670864.
• Cheng S, Jin P, Li H, Pei D, Shu X. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Front Pharmacol. 2021 Oct 18;12:740529. doi: 10.3389/fphar.2021.740529. PMID: 34733159; PMCID: PMC8558359.
• Wang X, Liang Y, Zhao J, Li Y, Gou S, Zheng M, Zhou J, Zhang Q, Mi J, Lai L. Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing. Cell Discov. 2021 Oct 12;7(1):92. doi: 10.1038/s41421-021-00304-y. Erratum in: Cell Discov. 2021 Dec 9;7(1):120. PMID: 34635647; PMCID: PMC8505425.
• Li Y, Huang K. Human-animal interspecies chimerism via blastocyst complementation: advances, challenges and perspectives: a narrative review. Stem Cell Investig. 2021 Oct 11;8:20. doi: 10.21037/sci-2020-074. PMID: 34815975; PMCID: PMC8578738.
• Li L, Chen K, Wu Y, Xiang G, Liu X. Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes. J Genet Genomics. 2021 Oct 12:S1673-8527(21)00321-0. doi: 10.1016/j.jgg.2021.09.006. Epub ahead of print. PMID: 34648996.
• Xu Y, Tao J, Yu X, Wu Y, Chen Y, You K, Zhang J, Getachew A, Pan T, Zhuang Y, Yuan F, Yang F, Lin X, Li YX. Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression. JCI Insight. 2021 Oct 8;6(19):e147038. doi: 10.1172/jci.insight.147038. PMID: 34622799; PMCID: PMC8525641.
• Zhou M, Xing Q, Zhang D, Zhang C, Zhang Y, Zhang J, Shan Y. Generation of an Akaluc knock-in human embryonic stem cell reporter line using CRISPR-Cas9 technology. Stem Cell Res. 2021 Oct;56:102532. doi: 10.1016/j.scr.2021.102532. Epub 2021 Sep 4. PMID: 34509917.
• He JP, Chen JK. Epigenetic control of transposable elements and cell fate decision. Yi Chuan. 2021 Sep 20;43(9):822-834. doi: 10.16288/j.yczz.21-113. PMID: 34702696.
• Long Y, Hou J, Tang F, Lin Z, Huang X, Li W, Chen Y, Li Z, Wu Z. Proarrhythmic effects induced by benzethonium chloride and domiphen bromide in vitro and in vivo. Toxicol Appl Pharmacol. 2021 Nov 15;431:115731. doi: 10.1016/j.taap.2021.115731. Epub 2021 Sep 27. PMID: 34592322.
• Li Y, Feng C, Chen Y, Huang K, Li C, Xiong X, Li P, Zhou D, Peng X, Weng W, Deng X, Wu Y, Fang J. Improved Outcomes with Induction Chemotherapy Combined with Arsenic Trioxide in Stage 4 Neuroblastoma: A Case Series. Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211041454. doi: 10.1177/15330338211041454. PMID: 34569870; PMCID: PMC8485563.
• He L, Wang S, Peng L, Zhao H, Li S, Han X, Habimana JD, Chen Z, Wang C, Peng Y, Peng H, Xie Y, Lei L, Deng Q, Wan L, Wan N, Yuan H, Gong Y, Zou G, Li Z, Tang B, Jiang H. CRISPR/Cas9 mediated gene correction ameliorates abnormal phenotypes in spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cells. Transl Psychiatry. 2021 Sep 17;11(1):479. doi: 10.1038/s41398-021-01605-2. PMID: 34535635; PMCID: PMC8448778.
• Long Q, Qi J, Li W, Zhou Y, Chen K, Wu H, Liu X. Protocol for detecting chromatin dynamics and screening chromatin relaxer by FRAP assay. STAR Protoc. 2021 Jul 30;2(3):100706. doi: 10.1016/j.xpro.2021.100706. PMID: 34401775; PMCID: PMC8348307.
• Zhao Y, Wang T, Zhang Y, Shi L, Zhang C, Zhang J, Yao J, Chen Q, Zhong X, Wei Y, Shan Y, Pan G. Coordination of EZH2 and SOX2 specifies human neural fate decision. Cell Regen. 2021 Sep 6;10(1):30. doi: 10.1186/s13619-021-00092-6. PMID: 34487238; PMCID: PMC8421500.
• 方仕才，黄依，王波，赵国庆，李陈，明金，董春阳，李闯，裴端卿. 敲降同源异形框D12抑制7因子介导的体细胞重编程. 中国生物化学与分子生物学报. 2021,37(09): 1188～ 1196.
• Tang X, Wu H, Xie J, Wang N, Chen Q, Zhong Z, Qiu Y, Wang J, Li X, Situ P, Lai L, Zern MA, Chen H, Duan Y. The combination of dextran sulphate and polyvinyl alcohol prevents excess aggregation and promotes proliferation of pluripotent stem cells in suspension culture. Cell Prolif. 2021 Sep;54(9):e13112. doi: 10.1111/cpr.13112. Epub 2021 Aug 13. PMID: 34390064; PMCID: PMC8450127.
• Zou Q, Qi H. Deletion of ribosomal paralogs Rpl39 and Rpl39l compromises cell proliferation via protein synthesis and mitochondrial activity. Int J Biochem Cell Biol. 2021 Oct;139:106070. doi: 10.1016/j.biocel.2021.106070. Epub 2021 Aug 21. PMID: 34428590.
• Chen P, Saiyin H, Shi R, Liu B, Han X, Gao Y, Ye X, Zhang X, Sun Y. Loss of SPACA1 function causes autosomal recessive globozoospermia by damaging the acrosome-acroplaxome complex. Hum Reprod. 2021 Aug 18;36(9):2587-2596. doi: 10.1093/humrep/deab144. PMID: 34172998.
• Feng C, Shi J, Fan Q, Wang Y, Huang H, Chen F, Tang G, Li Y, Li P, Li J, Cui J, Guo L, Chen S, Jiang M, Feng L, Chen L, Lei C, Ke C, Deng X, Hu F, Tang X, Li F. Protective humoral and cellular immune responses to SARS-CoV-2 persist up to 1 year after recovery. Nat Commun. 2021 Aug 17;12(1):4984. doi: 10.1038/s41467-021-25312-0. PMID: 34404803; PMCID: PMC8370972.
• Philonenko ES, Tan Y, Wang C, Zhang B, Shah Z, Zhang J, Ullah H, Kiselev SL, Lagarkova MA, Li D, Dai Y, Samokhvalov IM. Recapitulative haematopoietic development of human pluripotent stem cells in the absence of exogenous haematopoietic cytokines. J Cell Mol Med. 2021 Sep;25(18):8701-8714. doi: 10.1111/jcmm.16826. Epub 2021 Aug 2. PMID: 34342123; PMCID: PMC8435420.
• 董春阳，王波，明金，李陈，方仕才，黄依，刘晶. CRISPR/Cas9介导的Suds3敲除抑制小鼠胚胎干细胞增殖和中内胚层分化. 中国生物化学与分子生物学报. 2021,37(08):1050~1061.
• Liu Y, He J, Chen R, Liu H, Chen J, Liu Y, Wang B, Guo L, Pei D, Wang J, Liu J, Chen J. AP-1 activity is a major barrier of human somatic cell reprogramming. Cell Mol Life Sci. 2021 Aug;78(15):5847-5863. doi: 10.1007/s00018-021-03883-x. Epub 2021 Jun 28. PMID: 34181046.
• Pang N, Shi J, Qin L, Chen A, Tang Y, Yang H, Huang Y, Wu Q, Li X, He B, Li T, Liang B, Zhang J, Cao B, Liu M, Feng Y, Ye X, Chen X, Wang L, Tian Y, Li H, Li J, Hu H, He J, Hu Y, Zhi C, Tang Z, Gong Y, Xu F, Xu L, Fan W, Zhao M, Chen D, Lian H, Yang L, Li P, Zhang Z. IL-7 and CCL19-secreting CAR-T cell therapy for tumors with positive glypican-3 or mesothelin. J Hematol Oncol. 2021 Jul 29;14(1):118. doi: 10.1186/s13045-021-01128-9. PMID: 34325726; PMCID: PMC8323212.
• Shi R, Shi X, Qin D, Tang S, Vermeulen M, Zhang X. SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation. Cell Biosci. 2021 Jul 27;11(1):146. doi: 10.1186/s13578-021-00659-5. PMID: 34315543; PMCID: PMC8314547.
• Zhao R, Cui Y, Zheng Y, Li S, Lv J, Wu Q, Long Y, Wang S, Yao Y, Wei W, Yang J, Wang BC, Zhang Z, Zeng H, Li Y, Li P. Human Hyaluronidase PH20 Potentiates the Antitumor Activities of Mesothelin-Specific CAR-T Cells Against Gastric Cancer. Front Immunol. 2021 Jul 13;12:660488. doi: 10.3389/fimmu.2021.660488. PMID: 34326835; PMCID: PMC8313856.
• Liao J, Suen HC, Luk ACS, Yang L, Lee AWT, Qi H, Lee TL. Transcriptomic and epigenomic profiling of young and aged spermatogonial stem cells reveals molecular targets regulating differentiation. PLoS Genet. 2021 Jul 8;17(7):e1009369. doi: 10.1371/journal.pgen.1009369. PMID: 34237055; PMCID: PMC8291634.
• Qian Y, Zhao D, Sui T, Chen M, Liu Z, Liu H, Zhang T, Chen S, Lai L, Li Z. Efficient and precise generation of Tay-Sachs disease model in rabbit by prime editing system. Cell Discov. 2021 Jul 6;7(1):50. doi: 10.1038/s41421-021-00276-z. PMID: 34230459; PMCID: PMC8260710.
• Fu M, Chen H, Cai Z, Yang Y, Feng Z, Zeng M, Chen L, Qin Y, Cai B, Zhu P, Zhou C, Yu S, Guo J, Liu J, Cao S, Pei D. Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency. Cell Regen. 2021 Jul 2;10(1):17. doi: 10.1186/s13619-021-00078-4. PMID: 34212295; PMCID: PMC8249537.
• Liu C, Wang X, Huang W, Meng W, Su Z, Xing Q, Shi H, Zhang D, Zhou M, Zhao Y, Wang H, Pan G, Zhong X, Pei D, Guo Y. Hypoproliferative human neural progenitor cell xenografts survived extendedly in the brain of immunocompetent rats. Stem Cell Res Ther. 2021 Jul 2;12(1):376. doi: 10.1186/s13287-021-02427-1. PMID: 34215315; PMCID: PMC8254296.
• Kuang J, Zhai Z, Li P, Shi R, Guo W, Yao Y, Guo J, Zhao G, He J, Xu S, Wu C, Yu S, Zhou C, Wu L, Qin Y, Cai B, Li W, Wu Z, Li X, Chu S, Yang T, Wang B, Cao S, Li D, Zhang X, Chen J, Liu J, Pei D. SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun. 2021 Jul 2;12(1):4090. doi: 10.1038/s41467-021-24373-5. PMID: 34215745; PMCID: PMC8253816.
• Hu J, Wang T, Xu J, Wu S, Wang L, Su H, Jiang J, Yue M, Wang J, Wang D, Li P, Zhou F, Liu Y, Qing G, Liu H. WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia. Haematologica. 2021 Jul 1;106(7):1816-1827. doi: 10.3324/haematol.2019.231126. PMID: 31919076; PMCID: PMC8252940.
• Getachew A, Yang Z, Huang X, Wu F, Liu YY, Yan C, Yang F, Li Y. Generation of a TLR2 homozygous knockout human embryonic stem cell line WAe001-A-64 using CRISPR/Cas9 editing. Stem Cell Res. 2021 Jul;54:102401. doi: 10.1016/j.scr.2021.102401. Epub 2021 May 21. PMID: 34058685.
• Yuan F, Wang N, Chen Y, Huang X, Yang Z, Xu Y, You K, Zhang J, Wang G, Zhuang Y, Pan T, Xiong Y, Yu X, Yang F, Li Y. Calcitriol promotes the maturation of hepatocyte-like cells derived from human pluripotent stem cells. J Steroid Biochem Mol Biol. 2021 Jul;211:105881. doi: 10.1016/j.jsbmb.2021.105881. Epub 2021 Mar 22. PMID: 33766737.
• Ye X, Liu X, Shu T, Deng W, Liao M, Zheng Y, Zheng X, Zhang X, Li T, Fan W, Qu L, Chen L, Li F, Feng L. A Live-Attenuated Zika Virus Vaccine with High Production Capacity Confers Effective Protection in Neonatal Mice. J Virol. 2021 Jun 24;95(14):e0038321. doi: 10.1128/JVI.00383-21. Epub 2021 Jun 24. PMID: 33910950; PMCID: PMC8223925.
• Liu Z, Chen S, Xie W, Song Y, Li J, Lai L, Li Z. Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9. Mol Ther. 2022 Jan 5;30(1):256-267. doi: 10.1016/j.ymthe.2021.06.013. Epub 2021 Jun 24. PMID: 34174445; PMCID: PMC8753289.
• Ying Z, Liu Z, Xiang G, Xin Y, Wang J, Liu X. Protocols for analysis of mitochondrial permeability transition pore opening in mouse somatic cell reprogramming. STAR Protoc. 2021 Jun 2;2(2):100568. doi: 10.1016/j.xpro.2021.100568. PMID: 34151295; PMCID: PMC8188620.
• Yu C, You M, Zhang P, Zhang S, Yin Y, Zhang X. A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix. Cancer Med. 2021 Jul;10(13):4629-4643. doi: 10.1002/cam4.3986. Epub 2021 Jun 14. PMID: 34121340; PMCID: PMC8267129.
• Wu L, Zhao G, Xu S, Kuang J, Ming J, Wu G, Wang T, Wang B, Zhu P, Pei D, Liu J. The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure. J Biol Chem. 2021 Jan-Jun;296:100022. doi: 10.1074/jbc.RA120.014598. Epub 2020 Nov 23. PMID: 33144328; PMCID: PMC7948406.
• Yan Y, Jing S, Feng L, Zhang J, Zeng Z, Li M, Zhao S, Ou J, Lan W, Guan W, Wu X, Wu J, Seto D, Zhang Q. Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: "Adenovirus Vaccine Within an Adenovirus Vector". Virol Sin. 2021 Jun;36(3):354-364. doi: 10.1007/s12250-020-00234-1. Epub 2020 May 26. PMID: 32458297; PMCID: PMC7248191.
• Wang J, Shu T, Deng W, Zheng Y, Liao M, Ye X, Han L, He P, Zheng X, Li T, Feng Y, Hu F, Li P, Sun C, Chen L, Li F, Feng L. Mucosal Priming with a Recombinant Influenza A Virus-Vectored Vaccine Elicits T-Cell and Antibody Responses to HIV-1 in Mice. J Virol. 2021 May 24;95(12):e00059-21. doi: 10.1128/JVI.00059-21. PMID: 33789991; PMCID: PMC8315921.
• Shan H, Liu Z, Jia Y, Chen S, Chen M, Song Y, Sui T, Lai L, Li Z. Reduced off-target effect of NG-BE4max by using NG-HiFi system. Mol Ther Nucleic Acids. 2021 May 19;25:168-172. doi: 10.1016/j.omtn.2021.05.012. PMID: 34458002; PMCID: PMC8368781.
• He L, Han X, Zhao H, Li S, Chen Z, Wang C, Wang S, Peng L, Deng W, Li Z, Tang B, Jiang H. Generation of spinocerebellar ataxia type 3 patient-derived induced pluripotent stem cell line (CSUXHi005-A) from human urine epithelial cells. Stem Cell Res. 2021 May;53:102289. doi: 10.1016/j.scr.2021.102289. Epub 2021 Mar 17. PMID: 33761381.
• Wu F, Chen Y, You K, Tan S, Xu Y, Wang PH, Liu S, Li YX. Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein. Stem Cell Res. 2021 May;53:102197. doi: 10.1016/j.scr.2021.102197. Epub 2021 Jan 26. PMID: 33771478; PMCID: PMC7835078.
• Li Y, Li J, Zhou T, Pan G, Huang K. Generation of PARP1 gene knockout human embryonic stem cell line using CRISPR/Cas9. Stem Cell Res. 2021 May;53:102288. doi: 10.1016/j.scr.2021.102288. Epub 2021 Mar 13. PMID: 33740642.
• Jiang Z, Liao R, Lv J, Li S, Zheng D, Qin L, Wu D, Chen S, Long Y, Wu Q, Wang S, Lin S, Huang X, Tang Z, Shi P, Zhou H, Liu Q, Zhao R, Li Y, Jie Y, Wei W, Lai P, Du X, Cui S, Weinkove R, Liu P, Pei D, Yao Y, Li P. IL-6 trans-signaling promotes the expansion and anti-tumor activity of CAR T cells. Leukemia. 2021 May;35(5):1380-1391. doi: 10.1038/s41375-020-01085-1. Epub 2020 Nov 9. PMID: 33168950.
• Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G, Yao H. RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Prolif. 2021 May;54(5):e13000. doi: 10.1111/cpr.13000. Epub 2021 Mar 5. PMID: 33666296; PMCID: PMC8088469.
• Getachew A, Abbas N, You K, Yang Z, Hussain M, Huang X, Cheng Z, Tan S, Tao J, Yu X, Chen Y, Yang F, Pan T, Xu Y, Xu G, Zhuang Y, Wu F, Li Y. SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury. iScience. 2021 Apr 29;24(5):102483. doi: 10.1016/j.isci.2021.102483. PMID: 34113824; PMCID: PMC8169952.
• Chen M, Shi H, Gou S, Wang X, Li L, Jin Q, Wu H, Zhang H, Li Y, Wang L, Li H, Lin J, Guo W, Jiang Z, Yang X, Xu A, Zhu Y, Zhang C, Lai L, Li X. In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers. Genome Med. 2021 Apr 12;13(1):57. doi: 10.1186/s13073-021-00876-0. PMID: 33845891; PMCID: PMC8042958.
• Lin S, Cheng L, Ye W, Li S, Zheng D, Qin L, Wu Q, Long Y, Lin S, Wang S, Huang G, Li P, Yao Y, Sun X. Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86-Positive B Cell Malignancies. Front Immunol. 2021 Apr 2;12:642528. doi: 10.3389/fimmu.2021.642528. PMID: 33868277; PMCID: PMC8050336.
• Zhang C, Wei Y, Zhang Y, Zhang J, Xing Q, Zhou M, Shan Y. Establishment of a CRISPR/Cas9-mediated ANP32A homozygous knockout human embryonic stem cell line. Stem Cell Res. 2021 Apr;52:102234. doi: 10.1016/j.scr.2021.102234. Epub 2021 Feb 11. PMID: 33607472.
• Shi P, Zha J, Feng J, Jiang Z, Zhao H, Deng M, Liao N, Li P, Jiang Y, Song H, Xu B. Low-Dose Triptolide Enhanced Activity of Idarubicin Against Acute Myeloid Leukemia Stem-like Cells Via Inhibiting DNA Damage Repair Response. Stem Cell Rev Rep. 2021 Apr;17(2):616-627. doi: 10.1007/s12015-020-10054-1. Epub 2020 Oct 19. PMID: 33078278.
• Ren X, Wen W, Fan X, et al. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas [published correction appears in Cell. 2021 Nov 11;184(23):5838]. Cell. 2021;184(7):1895-1913.e19. doi:10.1016/j.cell.2021.01.053
• Liu X, Zhang Y, Chu Y, Zhao X, Mao L, Zhao S, Lin S, Hui X, Gu P, Xu Y, Loomes K, Tang S, Nie T, Wu D. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. Biochem Biophys Res Commun. 2021 Mar 19;545:189-194. doi: 10.1016/j.bbrc.2021.01.080. Epub 2021 Feb 6. PMID: 33561654.
• Lv Y, Bu C, Meng J, Ward C, Volpe G, Hu J, Jiang M, Guo L, Chen J, Esteban MA, Bao X, Cheng Z. Global Profiling of the Lysine Crotonylome in Different Pluripotent States. Genomics Proteomics Bioinformatics. 2021 Mar 18:S1672-0229(21)00073-5. doi: 10.1016/j.gpb.2021.01.004. Epub ahead of print. PMID: 33746086.
• Li S, Zhao H, Han X, Ni B, He L, Mukama O, de Dieu Habimana J, Lin Z, Huang R, Huang H, Tian C, Tang F, Li Z. Generation of UCiPSC-derived neurospheres for cell therapy and its application. Stem Cell Res Ther. 2021 Mar 18;12(1):188. doi: 10.1186/s13287-021-02238-4. PMID: 33736654; PMCID: PMC7977190.
• Liu P, Chen S, Wang Y, Chen X, Guo Y, Liu C, Wang H, Zhao Y, Wu D, Shan Y, Zhang J, Wu C, Li D, Zhang Y, Zhou T, Chen Y, Liu X, Li C, Wang L, Jia B, Liu J, Feng B, Cai J, Pei D. Efficient induction of neural progenitor cells from human ESC/iPSCs on Type I Collagen. Sci China Life Sci. 2021 Dec;64(12):2100-2113. doi: 10.1007/s11427-020-1897-0. Epub 2021 Mar 16. PMID: 33740188.
• Guo J, Duan L, He X, Li S, Wu Y, Xiang G, Bao F, Yang L, Shi H, Gao M, Zheng L, Hu H, Liu X. A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. Advanced Science. 2021 Mar 8;8(10):2004680. doi: 10.1002/advs.202004680. PMID: 34026460; PMCID: PMC8132052.
• He J, Babarinde IA, Sun L, Xu S, Chen R, Shi J, Wei Y, Li Y, Ma G, Zhuang Q, Hutchins AP, Chen J. Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE. Nature Communications. 2021 Mar 5;12(1):1456. doi: 10.1038/s41467-021-21808-x. PMID: 33674594; PMCID: PMC7935913.
• Li N, Gou S, Wang J, Zhang Q, Huang X, Xie J, Li L, Jin Q, Ouyang Z, Chen F, Ge W, Shi H, Liang Y, Zhuang Z, Zhao X, Lian M, Ye Y, Quan L, Wu H, Lai L, Wang K. CRISPR/Cas9-Mediated Gene Correction in Newborn Rabbits with Hereditary Tyrosinemia Type I. Mol Ther. 2021 Mar 3;29(3):1001-1015. doi: 10.1016/j.ymthe.2020.11.023. Epub 2020 Nov 20. PMID: 33221434; PMCID: PMC7934638.
• Liu J, Gao M, He J, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature. 2021 Mar;591(7849):322-326. doi: 10.1038/s41586-021-03313-9. Epub 2021 Mar 3. PMID: 33658714.
• Ji T, Li L, Li W, Zheng X, Ye X, Chen H, Zhou Q, Jia H, Chen B, Lin Z, Chen H, Huang S, Seto D, Chen L, Feng L. Emergence and characterization of a putative novel human adenovirus recombinant HAdV-C104 causing pneumonia in Southern China. Virus Evol. 2021 Mar 2;7(1):veab018. doi: 10.1093/ve/veab018. PMID: 33732504; PMCID: PMC7953211.
• Lv C, Chen S, Hu F, Huang D, Wang T, Du J, Wang J, Wu H. Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo. Cell Mol Immunol. 2021 Mar;18(3):773-775. doi: 10.1038/s41423-020-0429-4. Epub 2020 Jun 15. PMID: 32541834; PMCID: PMC8027670.
• Xiong Y, Chen Y, Huang X, Yang Z, Zhang J, Yu X, Fang J, Tao J, You K, Cheng Z, Tan S, Xu Y, Yuan F, Liu Y, Zhuang Y, Yang F, Li Y. Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity. Life Sci. 2021 Mar 1;268:119000. doi: 10.1016/j.lfs.2020.119000. Epub 2021 Jan 5. PMID: 33417961.
• Yang Z, Yuan F, Wang N, Liu Y, Zhang J, Wei R, Wu F, Wu Y, You K, Chen Y, Yang F, Li YX. Generation of a DKK1 homozygous knockout human embryonic stem cell line WAe001-A-21 using CRISPR/Cas9. Stem Cell Res. 2021 Mar;51:102161. doi: 10.1016/j.scr.2021.102161. Epub 2021 Jan 8. PMID: 33461039.
• Pan T, Tao J, Chen Y, Zhang J, Getachew A, Zhuang Y, Wang N, Xu Y, Tan S, Fang J, Yang F, Lin X, You K, Gao Y, Li YX. Robust expansion and functional maturation of human hepatoblasts by chemical strategy. Stem Cell Res Ther. 2021 Feb 25;12(1):151. doi: 10.1186/s13287-021-02233-9. PMID: 33632328; PMCID: PMC7908723.
• Yang Y, Kang X, Hu S, Chen B, Xie Y, Song B, Zhang Q, Wu H, Ou Z, Xian Y, Fan Y, Li X, Lai L, Sun X. CRISPR/Cas9-mediated β-globin gene knockout in rabbits recapitulates human β-thalassemia. J Biol Chem. 2021 Jan-Jun;296:100464. doi: 10.1016/j.jbc.2021.100464. Epub 2021 Feb 25. PMID: 33639162; PMCID: PMC8024976.
• Liu FL, Wu K, Sun J, Duan Z, Quan X, Kuang J, Chu S, Pang W, Gao H, Xu L, Li YC, Zhang HL, Wang XH, Luo RH, Feng XL, Schöler HR, Chen X, Pei D, Wu G, Zheng YT, Chen J. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation. Natl Sci Rev. 2020 Nov 24;8(2):nwaa285. doi: 10.1093/nsr/nwaa285. PMID: 34676093; PMCID: PMC7717373.
• Kanwal S, Guo X, Ward C, Volpe G, Qin B, Esteban MA, Bao X. Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency. Genomics Proteomics Bioinformatics. 2020 Feb;18(1):16-25. doi: 10.1016/j.gpb.2019.06.003. Epub 2020 May 21. PMID: 32445708; PMCID: PMC7393543.
• Wang Q, Xiong Y, Zhang S, Sui Y, Yu C, Liu P, Li H, Guo W, Gao Y, Przepiorski A, Davidson AJ, Guo M, Zhang X. The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics Approach. Front Genet. 2021 Feb 10;12:632810. doi: 10.3389/fgene.2021.632810. PMID: 33643392; PMCID: PMC7902935.
• Yu L, Liu X, Ye X, Su W, Zhang X, Deng W, Luo J, Xiang M, Guo W, Zhang S, Xu W, Yan Q, Wang Q, Cui Y, Wu C, Guo W, Niu X, Zhang F, Lei C, Qu L, Chen L, Feng L. Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fcγ Receptor-Dependent and -Independent Pathways. mBio. 2021 Feb 9;12(1):e03179-20. doi: 10.1128/mBio.03179-20. PMID: 33563822; PMCID: PMC7885117.
• Li D, Shu X, Zhu P, Pei D. Chromatin accessibility dynamics during cell fate reprogramming. EMBO Rep. 2021 Feb 3;22(2):e51644. doi: 10.15252/embr.202051644. Epub 2021 Jan 22. PMID: 33480184; PMCID: PMC7857421.
• Zhou J, Yan Q, Tang C, Liao Y, Zhang Q, Wang X, Zhou X, Lai L, Zou Q. Development of a rabbit model of Wiskott-Aldrich syndrome. FASEB J. 2021 Feb;35(2):e21226. doi: 10.1096/fj.202002118RR. Epub 2020 Nov 25. PMID: 33236397.
• Lin S, Zhang X, Huang G, Cheng L, Lv J, Zheng D, Lin S, Wang S, Wu Q, Long Y, Li B, Wei W, Liu P, Pei D, Li Y, Wen Z, Cui S, Li P, Sun X, Wu Y, Yao Y. Myeloid-derived suppressor cells promote lung cancer metastasis by CCL11 to activate ERK and AKT signaling and induce epithelial-mesenchymal transition in tumor cells. Oncogene. 2021 Feb;40(8):1476-1489. doi: 10.1038/s41388-020-01605-4. Epub 2021 Jan 15. PMID: 33452453.
• Lian M, Chen F, Huang X, Zhao X, Gou S, Li N, Jin Q, Shi H, Liang Y, Xie J, Ge W, Zhuang Z, Wang J, Ye Y, Yang Y, Wang K, Lai L, Wu H. Improving the Cpf1-mediated base editing system by combining dCas9/dead sgRNA with human APOBEC3A variants. J Genet Genomics. 2021 Jan 20;48(1):92-95. doi: 10.1016/j.jgg.2020.07.010. Epub 2020 Nov 7. PMID: 33504469.
• Yuan F, Xu Y, You K, Zhang J, Yang F, Li YX. Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy. Arch Biochem Biophys. 2021 Jan 15;697:108694. doi: 10.1016/j.abb.2020.108694. Epub 2020 Nov 21. PMID: 33232716.

重要文章

• Huang Y, Zhang H, Wang L, Tang C, Qin X, Wu X, Pan M, Tang Y, Yang Z, Babarinde IA, Lin R, Ji G, Lai Y, Xu X, Su J, Wen X, Satoh T, Ahmed T, Malik V, Ward C, Volpe G, Guo L, Chen J, Sun L, Li Y, Huang X, Bao X, Gao F, Liu B, Zheng H, Jauch R, Lai L, Pan G, Chen J, Testa G, Akira S, Hu J, Pei D, Hutchins AP, Esteban MA, Qin B. JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications. 2020 Oct 8;11(1):5061. doi: 10.1038/s41467-020-18900-z. PMID: 33033262; PMCID: PMC7545202.（揭示H3K27me3去甲基化酶JMJD3与KLF4在体细胞重编程中协同调控转录的新机制）
• Hu G, Dong X, Gong S, Song Y, Hutchins AP, Yao H. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research. 2020 Sep 25;48(17):9606-9620. doi: 10.1093/nar/gkaa705. PMID: 32885250; PMCID: PMC7515718.（揭示CTCF“染色质环“调控新因子）
• He J, Cai S, Feng H, Cai B, Lin L, Mai Y, Fan Y, Zhu A, Huang H, Shi J, Li D, Wei Y, Li Y, Zhao Y, Pan Y, Liu H, Mo X, He X, Cao S, Hu F, Zhao J, Wang J, Zhong N, Chen X, Deng X, Chen J. Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients. Protein & Cell. 2020 Sep;11(9):680-687. doi: 10.1007/s13238-020-00752-4. PMID: 32671793; PMCID: PMC7363016.（揭示新冠病毒感染导致急性呼吸窘迫症的细胞机理）
• Li L, Chen K, Wang T, Wu Y, Xing G, Chen M, Hao Z, Zhang C, Zhang J, Ma B, Liu Z, Yuan H, Liu Z, Long Q, Zhou Y, Qi J, Zhao D, Gao M, Pei D, Nie J, Ye D, Pan G, Liu X. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Nature Metabolism. 2020 Sep;2(9):882-892. doi: 10.1038/s42255-020-0267-9. Epub 2020 Aug 24. Erratum in: Nat Metab. 2020 Oct;2(10):1179. PMID: 32839595.（发现细胞命运调控的“表观组-代谢组-表观组”跨界蝴蝶效应）
• Zhang M, Lai Y, Krupalnik V, Guo P, Guo X, Zhou J, Xu Y, Yu Z, Liu L, Jiang A, Li W, Abdul MM, Ma G, Li N, Fu X, Lv Y, Jiang M, Tariq M, Kanwal S, Liu H, Xu X, Zhang H, Huang Y, Wang L, Chen S, Babarinde IA, Luo Z, Wang D, Zhou T, Ward C, He M, Ibañez DP, Li Y, Zhou J, Yuan J, Feng Y, Arumugam K, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Sun H, Gao F, Qin B, Hutchins AP, Doble BW, Hartmann C, Cosma MP, Qin Y, Xu GL, Chen R, Volpe G, Chen L, Hanna JH, Esteban MA. β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances. 2020 Jul 17;6(29):eaba1593. doi: 10.1126/sciadv.aba1593. PMID: 32832621; PMCID: PMC7439582.（阐明了基态多能干细胞具有和亚稳态多能干细胞不同的转录调控机制）
• Hu F, Huang D, Luo Y, Zhou P, Lv C, Wang K, Weng Q, Liu X, Guan Y, Geng Y, Du J, Chen J, Wang J, Wu H. Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells. Journal for ImmunoTherapy of Cancer. 2020 Jul;8(2):e000498. doi: 10.1136/jitc-2019-000498. PMID: 32669292; PMCID: PMC7368548.（一种通过血液谱系转分化途径产生抗肿瘤TCR-T细胞的新方法）
• Li Y, Song Y, Xu W, Li Q, Wang X, Li K, Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Schöler HR, Sun Q, Yao H. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. Science Advances. 2020 Jun 10;6(24):eaba0777. doi: 10.1126/sciadv.aba0777. PMID: 32704541; PMCID: PMC7360481.（揭示SOX2/DDX5与R-loop协同调控体细胞重编程为诱导多能干细胞的新机制）
• Yu S, Zhou C, Cao S, He J, Cai B, Wu K, Qin Y, Huang X, Xiao L, Ye J, Xu S, Xie W, Kuang J, Chu S, Guo J, Liu H, Pang W, Guo L, Zeng M, Wang X, Luo R, Li C, Zhao G, Wang B, Wu L, Chen J, Liu J, Pei D. BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling. Nature Cell Biology. 2020 Jun;22(6):651-662. doi: 10.1038/s41556-020-0516-x. Epub 2020 May 11. PMID: 32393886.（揭示小鼠多能干细胞始发态向原始态转变过程的分子机制）
• Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. EMBO Journal. 2020 Apr 15;39(8):e102961. doi: 10.15252/embj.2019102961. Epub 2020 Feb 24. PMID: 32090361; PMCID: PMC7156961.（揭示体细胞多能性调控的新机制）
• Zhou Y, Long Q, Wu H, Li W, Qi J, Wu Y, Xiang G, Tang H, Yang L, Chen K, Li L, Bao F, Li H, Wang Y, Li M, Liu X. Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy. 2020 Mar;16(3):562-574. doi: 10.1080/15548627.2019.1634944. Epub 2019 Jul 4. PMID: 31234709; PMCID: PMC6999642.（发现线粒体”黑洞”吞噬与否的抉择规律）
• Shan Y, Zhang Y, Zhao Y, Wang T, Zhang J, Yao J, Ma N, Liang Z, Huang W, Huang K, Zhang T, Su Z, Chen Q, Zhu Y, Wu C, Zhou T, Sun W, Wei Y, Zhang C, Li C, Su S, Liao B, Zhong M, Zhong X, Nie J, Pei D, Pan G. JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells. Nature Communications. 2020 Jan 20;11(1):382. doi: 10.1038/s41467-019-14028-x. PMID: 31959746; PMCID: PMC6971254.（揭示H3K27me3去甲基化酶KDM6家族调控人神经发生的关键作用）
• Guo R, Hu F, Weng Q, Lv C, Wu H, Liu L, Li Z, Zeng Y, Bai Z, Zhang M, Liu Y, Liu X, Xia C, Wang T, Zhou P, Wang K, Dong Y, Luo Y, Zhang X, Guan Y, Geng Y, Du J, Li Y, Lan Y, Chen J, Liu B, Wang J. Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research. 2020 Jan;30(1):21-33. doi: 10.1038/s41422-019-0251-7. Epub 2019 Nov 15. PMID: 31729468; PMCID: PMC6951346.（建立了一种通过特定转录因子（Runx1和Hoxa9）组合诱导多能干细胞定向分化为T细胞种子的方法）
• Chen K, Long Q, Xing G, Wang T, Wu Y, Li L, Qi J, Zhou Y, Ma B, Schöler HR, Nie J, Pei D, Liu X. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal. 2020 Jan 2;39(1):e99165. doi: 10.15252/embj.201899165. Epub 2019 Oct 1. PMID: 31571238; PMCID: PMC6939195.（揭示iPS重编程因子解锁异染色质之谜）

所有文章

• Shim WJ, Sinniah E, Xu J, Vitrinel B, Alexanian M, Andreoletti G, Shen S, Sun Y, Balderson B, Boix C, Peng G, Jing N, Wang Y, Kellis M, Tam PPL, Smith A, Piper M, Christiaen L, Nguyen Q, Bodén M, Palpant NJ. Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity. Cell Systems. 2020 Dec 16;11(6):625-639.e13. doi: 10.1016/j.cels.2020.11.001. Epub 2020 Dec 4. PMID: 33278344; PMCID: PMC7781436.
• Xu Y, Zhou J, Liu C, Zhang S, Gao F, Guo W, Sun X, Zhang C, Li H, Rao Z, Qiu S, Zhu Q, Liu X, Guo X, Shao Z, Bai Y, Zhang X, Quan D. Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury. Biomaterials. 2021 Jan;268:120596. doi: 10.1016/j.biomaterials.2020.120596. Epub 2020 Dec 10. PMID: 33341040.
• Arumugam K, Shin W, Schiavone V, Vlahos L, Tu X, Carnevali D, Kesner J, Paull EO, Romo N, Subramaniam P, Worley J, Tan X, Califano A, Cosma MP. The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State. Cell Reports. 2020 Dec 8;33(10):108474. doi: 10.1016/j.celrep.2020.108474. PMID: 33296649; PMCID: PMC8049840.
• Zhu Y, Wang T, Gu J, Huang K, Zhang T, Zhang Z, Liu H, Tang J, Mai Y, Zhang Y, Li Y, Feng Y, Kang B, Li J, Shan Y, Chen Q, Zhang J, Long B, Wang J, Gao M, Zhang D, Zhou M, Zhong X, Chen J, Pei D, Nie J, Liu B, Pan G. Characterization and generation of human definitive multipotent hematopoietic stem/progenitor cells. Cell Discovery. 2020 Dec 1;6(1):89. doi: 10.1038/s41421-020-00213-6. PMID: 33298886; PMCID: PMC7705709.
• Hong W, Chen Y, You K, Tan S, Wu F, Tao J, Chen X, Zhang J, Xiong Y, Yuan F, Yang Z, Chen T, Chen X, Peng P, Tai Q, Wang J, Zhang F, Li YX. Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study. Frontiers in Pharmacology. 2020 Nov 6;11:561674. doi: 10.3389/fphar.2020.561674. PMID: 33312125; PMCID: PMC7703865.
• Tian C, Li S, He L, Han X, Tang F, Huang R, Lin Z, Deng S, Xu J, Huang H, Zhao H, Li Z. Transient receptor potential ankyrin 1 contributes to the lysophosphatidylcholine-induced oxidative stress and cytotoxicity in OLN-93 oligodendrocyte. Cell Stress & Chaperones. 2020 Nov;25(6):955-968. doi: 10.1007/s12192-020-01131-y. Epub 2020 Jun 22. PMID: 32572784; PMCID: PMC7591684.
• Li W, Shi L, Zhuang Z, Wu H, Lian M, Chen Y, Li L, Ge W, Jin Q, Zhang Q, Zhao Y, Liu Z, Ouyang Z, Ye Y, Li Y, Wang H, Liao Y, Quan L, Xiao L, Lai L, Meng G, Wang K. Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses. The Journal of Immunology. 2020 Nov 1;205(9):2532-2544. doi: 10.4049/jimmunol.1901468. Epub 2020 Sep 21. PMID: 32958688.
• Zhao H, Li S, Lin Z, He L, Deng W, Han X, Tang F, Cheng N, Zhou P, Huang R, Deng S, Huang J, Li Z. A heterozygous SCN1A (c.A5768G/+) mutant human induced pluripotent stem cell line (USTCi002-A) generated using TALEN-mediated precise gene editing. Stem Cell Research. 2020 Dec;49:102058. doi: 10.1016/j.scr.2020.102058. Epub 2020 Oct 16. PMID: 33189042.
• Huang Y, Zhang H, Wang L, Tang C, Qin X, Wu X, Pan M, Tang Y, Yang Z, Babarinde IA, Lin R, Ji G, Lai Y, Xu X, Su J, Wen X, Satoh T, Ahmed T, Malik V, Ward C, Volpe G, Guo L, Chen J, Sun L, Li Y, Huang X, Bao X, Gao F, Liu B, Zheng H, Jauch R, Lai L, Pan G, Chen J, Testa G, Akira S, Hu J, Pei D, Hutchins AP, Esteban MA, Qin B. JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. Nature Communications. 2020 Oct 8;11(1):5061. doi: 10.1038/s41467-020-18900-z. PMID: 33033262; PMCID: PMC7545202.
• Xu XY, Guo WJ, Pan SH, Zhang Y, Gao FL, Wang JT, Zhang S, Li HY, Wang R, Zhang X. TILRR (FREM1 isoform 2) is a prognostic biomarker correlated with immune infiltration in breast cancer. Aging-US. 2020 Oct 8;12(19):19335-19351. doi: 10.18632/aging.103798. Epub ahead of print. PMID: 33031059; PMCID: PMC7732299.
• Chen J. Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity. Current Opinion in Genetics & Development. 2020 Oct;64:21-25. doi: 10.1016/j.gde.2020.05.016. Epub 2020 Jun 26. PMID: 32599300.
• Lai P, Chen X, Qin L, Jiang Z, Luo C, Huang X, Wu S, Ling W, Wang Y, Wang J, Deng C, Huang L, Zeng L, Lu Z, Zhong L, Liao P, Li M, Chen D, Geng S, Wu P, Tang Z, Pei D, Du X, Li P, Weng J. The efficacy and safety of CAR-T cell therapy in patients with refractory ALL and concomitant HBV infection. Leukemia. 2020 Oct;34(10):2790-2793. doi: 10.1038/s41375-020-0952-4. Epub 2020 Jul 6. PMID: 32632097.
• Zhang M, Li Q, Yang T, Meng F, Lai X, Liang L, Li C, Sun H, Sun J, Zheng H. Positive feedback between retinoic acid and 2-phospho-L-ascorbic acid trisodium salt during somatic cell reprogramming. Cell Regeneration. 2020 Oct 1;9(1):17. doi: 10.1186/s13619-020-00057-1. PMID: 33000315; PMCID: PMC7527398.
• Wen S, Sun C, Zheng H, Wang L, Zhang H, Zou L, Liu Z, Du P, Xu X, Liang L, Peng X, Zhang W, Wu J, Yang J, Lei B, Zeng G, Ke C, Chen F, Zhang X. High-coverage SARS-CoV-2 genome sequences acquired by target capture sequencing. Journal of Medical Virology. 2020 Oct;92(10):2221-2226. doi: 10.1002/jmv.26116. Epub 2020 Jun 19. PMID: 32492196; PMCID: PMC7300714.
• Tian C, Han X, He L, Tang F, Huang R, Lin Z, Li S, Deng S, Xu J, Huang H, Zhao H, Li Z. Transient receptor potential ankyrin 1 contributes to the ATP-elicited oxidative stress and inflammation in THP-1-derived macrophage. Molecular and Cellular Biochemistry. 2020 Oct;473(1-2):179-192. doi: 10.1007/s11010-020-03818-3. Epub 2020 Jul 5. PMID: 32627113.
• Zhao H, He L, Huang H, Li S, Cheng N, Tang F, Han X, Lin Z, Huang R, Zhou P, Deng S, Huang J, Li Z. Generation of a tdTomato-GAD67 reporter human epilepsia mutation induced pluripotent stem cell line, USTCi001-A-2, using CRISPR/Cas9 editing. Stem Cell Research. 2020 Oct;48:102003. doi: 10.1016/j.scr.2020.102003. Epub 2020 Sep 17. PMID: 32977294.
• Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G. Identification of mecciRNAs and their roles in the mitochondrial entry of proteins. Science China-Life Sciences. 2020 Oct;63(10):1429-1449. doi: 10.1007/s11427-020-1631-9. Epub 2020 Jan 21. PMID: 32048164.
• Liu J, Pan T, Chen Y, Liu Y, Yang F, Chen Q, Abbas N, Zhong M, Zhang Q, Xu Y, Li YX. Repair of acute liver damage with immune evasive hESC derived hepato-blasts. Stem Cell Research. 2020 Dec;49:102010. doi: 10.1016/j.scr.2020.102010. Epub 2020 Sep 26. PMID: 33011360.
• Hu G, Dong X, Gong S, Song Y, Hutchins AP, Yao H. Systematic screening of CTCF binding partners identifies that BHLHE40 regulates CTCF genome-wide distribution and long-range chromatin interactions. Nucleic Acids Research. 2020 Sep 25;48(17):9606-9620. doi: 10.1093/nar/gkaa705. PMID: 32885250; PMCID: PMC7515718.
• Xie J, Huang X, Wang X, Gou S, Liang Y, Chen F, Li N, Ouyang Z, Zhang Q, Ge W, Jin Q, Shi H, Zhuang Z, Zhao X, Lian M, Wang J, Ye Y, Quan L, Wu H, Wang K, Lai L. ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems. BMC Biology. 2020 Sep 23;18(1):131. doi: 10.1186/s12915-020-00866-5. PMID: 32967664; PMCID: PMC7510086.
• Sun W, Zhang S, Zhou T, Shan Y, Gao F, Zhang Y, Zhang D, Xiong Y, Mai Y, Fan K, Davidson AJ, Pan G, Zhang X. Human Urinal Cell Reprogramming: Synthetic 3D Peptide Hydrogels Enhance Induced Pluripotent Stem Cell Population Homogeneity. ACS Biomaterials Science & Engineering. 2020 Nov 9;6(11):6263-6275. doi: 10.1021/acsbiomaterials.0c00667. Epub 2020 Oct 20. PMID: 33449655.
• Wang Y, Zheng JP, Luo Y, Wang J, Xu L, Wang J, Sedivy JM, Song Z, Wang H, Ju Z. L1 drives HSC aging and affects prognosis of chronic myelomonocytic leukemia. Signal Transduction and Targeted Therapy. 2020 Sep 19;5(1):205. doi: 10.1038/s41392-020-00279-4. PMID: 32951008; PMCID: PMC7502075.
• Chen S, Jia Y, Liu Z, Shan H, Chen M, Yu H, Lai L, Li Z. Robustly improved base editing efficiency of Cpf1 base editor using optimized cytidine deaminases. Cell Discovery. 2020 Sep 15;6:62. doi: 10.1038/s41421-020-00195-5. PMID: 33014423; PMCID: PMC7490413.
• Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J. YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. Cell Reports. 2020 Sep 8;32(10):108120. doi: 10.1016/j.celrep.2020.108120. PMID: 32905781.
• Aulicino F, Pedone E, Sottile F, Lluis F, Marucci L, Cosma MP. Canonical Wnt Pathway Controls mESC Self-Renewal Through Inhibition of Spontaneous Differentiation via β-Catenin/TCF/LEF Functions. Stem Cell Reports. 2020 Sep 8;15(3):646-661. doi: 10.1016/j.stemcr.2020.07.019. Epub 2020 Aug 20. PMID: 32822589; PMCID: PMC7486219.
• Chen S, Xie W, Liu Z, Shan H, Chen M, Song Y, Yu H, Lai L, Li Z. CRISPR Start-Loss: A Novel and Practical Alternative for Gene Silencing through Base-Editing-Induced Start Codon Mutations. Molecular Therapy-Nucleic Acids. 2020 Sep 4;21:1062-1073. doi: 10.1016/j.omtn.2020.07.037. Epub 2020 Jul 31. PMID: 32854061; PMCID: PMC7452150.
• Song Y, Liu Z, Zhang Y, Chen M, Sui T, Lai L, Li Z. Large-Fragment Deletions Induced by Cas9 Cleavage while Not in the BEs System. Molecular Therapy-Nucleic Acids. 2020 Sep 4;21:523-526. doi: 10.1016/j.omtn.2020.06.019. Epub 2020 Jun 25. PMID: 32711379; PMCID: PMC7381496.
• He J, Cai S, Feng H, Cai B, Lin L, Mai Y, Fan Y, Zhu A, Huang H, Shi J, Li D, Wei Y, Li Y, Zhao Y, Pan Y, Liu H, Mo X, He X, Cao S, Hu F, Zhao J, Wang J, Zhong N, Chen X, Deng X, Chen J. Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients. Protein & Cell. 2020 Sep;11(9):680-687. doi: 10.1007/s13238-020-00752-4. PMID: 32671793; PMCID: PMC7363016.
• Li L, Chen K, Wang T, Wu Y, Xing G, Chen M, Hao Z, Zhang C, Zhang J, Ma B, Liu Z, Yuan H, Liu Z, Long Q, Zhou Y, Qi J, Zhao D, Gao M, Pei D, Nie J, Ye D, Pan G, Liu X. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. Nature Metabolism. 2020 Sep;2(9):882-892. doi: 10.1038/s42255-020-0267-9. Epub 2020 Aug 24. Erratum in: Nat Metab. 2020 Oct;2(10):1179. PMID: 32839595.
• Xia C, Wang T, Cheng H, Dong Y, Weng Q, Sun G, Zhou P, Wang K, Liu X, Geng Y, Ma S, Hao S, Xu L, Guan Y, Du J, Du X, Li Y, Zhu X, Shi Y, Xu S, Wang D, Cheng T, Wang J. Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia. 2020 Sep;34(9):2375-2383. doi: 10.1038/s41375-020-0775-3. Epub 2020 Feb 24. PMID: 32094463; PMCID: PMC7987218.
• Dong Y, Wang K, Weng Q, Wang T, Zhou P, Liu X, Geng Y, Liu L, Wu H, Wang J, Du J. NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting. Cell Proliferation. 2020 Sep;53(9):e12885. doi: 10.1111/cpr.12885. Epub 2020 Jul 29. PMID: 32725842; PMCID: PMC7507399.
• Yang L, Lin X, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD⁺ redox. Aging Cell. 2020 Sep;19(9):e13206. doi: 10.1111/acel.13206. Epub 2020 Aug 3. PMID: 32744417; PMCID: PMC7511885.
• Yan H, Niimi M, Matsuhisa F, Zhou H, Kitajima S, Chen Y, Wang C, Yang X, Yao J, Yang D, Zhang J, Murakami M, Nakajima K, Wang Y, Liu E, Liang J, Chen YE, Fan J. Apolipoprotein CIII Deficiency Protects Against Atherosclerosis in Knockout Rabbits. Arteriosclerosis Thrombosis and Vascular Biology. 2020 Sep;40(9):2095-2107. doi: 10.1161/ATVBAHA.120.314368. Epub 2020 Aug 6. PMID: 32757647; PMCID: PMC7484272.
• Peng G, Cui G, Ke J, Jing N. Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annual Review of Genomics and Human Genetics. 2020 Aug 31;21:163-181. doi: 10.1146/annurev-genom-120219-083220. Epub 2020 Apr 27. PMID: 32339035.
• Liu Z, Chen S, Shan H, Jia Y, Chen M, Song Y, Lai L, Li Z. Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions. BMC Biology. 2020 Aug 31;18(1):111. doi: 10.1186/s12915-020-00849-6. PMID: 32867757; PMCID: PMC7461344.
• Abbas N, Getachew A, You K, Shah Z, Chen Y, Tao J, Hussain M, Yang F, Zhuang Y, Xu Y, Li YX. Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage. Biochemical and Biophysical Research Communications. 2020 Aug 20;529(2):474-479. doi: 10.1016/j.bbrc.2020.06.041. Epub 2020 Jul 2. PMID: 32703454.
• Liu H, Xu Y, Yao B, Sui T, Lai L, Li Z. A novel N6-methyladenosine (m6A)-dependent fate decision for the lncRNA THOR. Cell Death & Disease. 2020 Aug 13;11(8):613. doi: 10.1038/s41419-020-02833-y. PMID: 32792482; PMCID: PMC7426843.
• Lai X, Li Q, Wu F, Lin J, Chen J, Zheng H, Guo L. Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming. Frontiers in Cell and Developmental Biology. 2020 Aug 6;8:760. doi: 10.3389/fcell.2020.00760. PMID: 32850862; PMCID: PMC7423833.
• Liang M, Sui T, Liu Z, Chen M, Liu H, Shan H, Lai L, Li Z. AcrIIA5 Suppresses Base Editors and Reduces Their Off-Target Effects. Cells. 2020 Jul 27;9(8):1786. doi: 10.3390/cells9081786. PMID: 32727031; PMCID: PMC7463901.
• Zhang M, Lai Y, Krupalnik V, Guo P, Guo X, Zhou J, Xu Y, Yu Z, Liu L, Jiang A, Li W, Abdul MM, Ma G, Li N, Fu X, Lv Y, Jiang M, Tariq M, Kanwal S, Liu H, Xu X, Zhang H, Huang Y, Wang L, Chen S, Babarinde IA, Luo Z, Wang D, Zhou T, Ward C, He M, Ibañez DP, Li Y, Zhou J, Yuan J, Feng Y, Arumugam K, Di Vicino U, Bao X, Wu G, Schambach A, Wang H, Sun H, Gao F, Qin B, Hutchins AP, Doble BW, Hartmann C, Cosma MP, Qin Y, Xu GL, Chen R, Volpe G, Chen L, Hanna JH, Esteban MA. β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances. 2020 Jul 17;6(29):eaba1593. doi: 10.1126/sciadv.aba1593. PMID: 32832621; PMCID: PMC7439582.
• Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D. The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming. Cell Reports. 2020 Jul 14;32(2):107877. doi: 10.1016/j.celrep.2020.107877. PMID: 32668244.
• Zhou P, Xie W, Huang HL, Huang RQ, Tian C, Zhu HB, Dai YH, Li ZY. circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1α pathway. Aging-US. 2020 Jul 8;12(13):13338-13353. doi: 10.18632/aging.103438. Epub 2020 Jul 8. PMID: 32644049; PMCID: PMC7377858.
• Fan C, Shah Z, Ullah H, Philonenko ES, Zhang B, Tan Y, Wang C, Zhang J, Samokhvalov IM. TALEN-mediated biallelic inactivation of MYB in human embryonic stem cell lines WAe001-A-45 and WAe001-A-46. Stem Cell Research. 2020 Jul;46:101854. doi: 10.1016/j.scr.2020.101854. Epub 2020 Jun 1. PMID: 32526676.
• Zhao H, He L, Li S, Huang H, Tang F, Han X, Lin Z, Tian C, Huang R, Zhou P, Huang J, Deng S, Li Z. Generation of corrected-hiPSC (USTCi001-A-1) from epilepsy patient iPSCs using TALEN-mediated editing of the SCN1A gene. Stem Cell Research. 2020 Jul;46:101864. doi: 10.1016/j.scr.2020.101864. Epub 2020 Jun 9. PMID: 32544858.
• Li Y, Ibañez DP, Fan W, Zhao P, Chen S, Md Abdul M, Jiang Y, Fu L, Luo Z, Liu Z, Yang Y, Guo J, Volpe G, Kanwal S, Wang D, Tang B, Li W. Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P). Stem Cell Research. 2020 Jul;46:101845. doi: 10.1016/j.scr.2020.101845. Epub 2020 May 27. PMID: 32534165.
• Huang HL, Li C, Ma W, Yin S, Zhao H, Deng S, Shu X, Wu D, Li J, Huang R, Cheng N, Huang J, Li Z. Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour. Genes Brain and Behavior. 2020 Jul;19(6):e12625. doi: 10.1111/gbb.12625. Epub 2019 Dec 15. PMID: 31730264.
• Hu F, Huang D, Luo Y, Zhou P, Lv C, Wang K, Weng Q, Liu X, Guan Y, Geng Y, Du J, Chen J, Wang J, Wu H. Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells. Journal for ImmunoTherapy of Cancer. 2020 Jul;8(2):e000498. doi: 10.1136/jitc-2019-000498. PMID: 32669292; PMCID: PMC7368548.
• Zhou Y, Long Q, Liu X. A new sight: topology-dependent mitophagy. Cell Biology and Toxicology. 2020 Jun;36(3):199-204. doi: 10.1007/s10565-020-09534-4. Epub 2020 Jun 11. PMID: 32529329.
• Li Y, Song Y, Xu W, Li Q, Wang X, Li K, Wang J, Liu Z, Velychko S, Ye R, Xia Q, Wang L, Guo R, Dong X, Zheng Z, Dai Y, Li H, Yao M, Xue Y, Schöler HR, Sun Q, Yao H. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. Science Advances. 2020 Jun 10;6(24):eaba0777. doi: 10.1126/sciadv.aba0777. PMID: 32704541; PMCID: PMC7360481.
• Qin L, Zhao R, Chen D, Wei X, Wu Q, Long Y, Jiang Z, Li Y, Wu H, Zhang X, Wu Y, Cui S, Wei W, Yao H, Liu Z, Cao S, Yao Y, Zhang Z, Li P. Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth. Biomarker Research. 2020 Jun 3;8:19. doi: 10.1186/s40364-020-00198-0. PMID: 32514352; PMCID: PMC7268496.
• Yu S, Zhou C, Cao S, He J, Cai B, Wu K, Qin Y, Huang X, Xiao L, Ye J, Xu S, Xie W, Kuang J, Chu S, Guo J, Liu H, Pang W, Guo L, Zeng M, Wang X, Luo R, Li C, Zhao G, Wang B, Wu L, Chen J, Liu J, Pei D. BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling. Nature Cell Biology. 2020 Jun;22(6):651-662. doi: 10.1038/s41556-020-0516-x. Epub 2020 May 11. PMID: 32393886.
• Yang Z, Zheng C, Zhang F, Lin B, Cao M, Tian X, Zhang J, Zhang X, Shen J. Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis. Muscle & Nerve. 2020 Jun;61(6):815-825. doi: 10.1002/mus.26862. Epub 2020 Apr 6. PMID: 32170960.
• Tu Y, Fang J, Yin M, Yu W, Li Y. A Cured Coronavirus Disease 2019 Case of an 86-Year-Old With 13 Chronic Diseases: A Case Report.JTO Clinical and Research Reports. 2020 Jun;1(2):100038. doi: 10.1016/j.jtocrr.2020.100038. Epub 2020 Dec 22. PMID: 33354680; PMCID: PMC7148978.
• Dong F, Hao S, Zhang S, Zhu C, Cheng H, Yang Z, Hamey FK, Wang X, Gao A, Wang F, Gao Y, Dong J, Wang C, Wang J, Lan Y, Liu B, Ema H, Tang F, Göttgens B, Zhu P, Cheng T. Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis. Nature Cell Biology. 2020 Jun;22(6):630-639. doi: 10.1038/s41556-020-0512-1. Epub 2020 May 4. PMID: 32367048.
• Wang X, Shi H, Zhou J, Zou Q, Zhang Q, Gou S, Chen P, Mou L, Fan N, Suo Y, Ouyang Z, Lai C, Yan Q, Lai L. Generation of rat blood vasculature and hematopoietic cells in rat-mouse chimeras by blastocyst complementation. Journal of Genetics and Genomics. 2020 May 20;47(5):249-261. doi: 10.1016/j.jgg.2020.05.002. Epub 2020 May 19. PMID: 32703661.
• Huang M, Tang T, Pang P, Li M, Ma R, Lu J, Shu J, You Y, Chen B, Liang J, Hong Z, Chen H, Kong L, Qin D, Pei D, Xia J, Jiang S, Shan H. Treating COVID-19 with Chloroquine. Journal of Molecular Cell Biology. 2020 May 18;12(4):322-325. doi: 10.1093/jmcb/mjaa014. PMID: 32236562; PMCID: PMC7232130.
• Cheng, N., Liu, Y., Mukama, O., Han, X., Huang, H., Li, S., … Li, Z. (2020). A signal-enhanced and sensitive lateral flow aptasensor for the rapid detection of PDGF-BB. RSC Advances, 10(32), 18601–18607. doi:10.1039/d0ra02662j
• Yao B, Liang M, Liu H, Sui T, Song Y, Zhang Y, Deng J, Xu Y, Lai L, Li Z. The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation. RNA Biology. 2020 May;17(5):623-629. doi: 10.1080/15476286.2020.1725725. Epub 2020 Feb 9. PMID: 32036747; PMCID: PMC7237162.
• Ullah H, You H, Shah Z, Fan C, Zhang B, Liu H, Zhang J, Abbas N, Filonenko ES, Samokhvalov IM. Generation of RUNX1-null reporter human embryonic stem cell line GIBHe008-A. Stem Cell Research. 2020 May;45:101800. doi: 10.1016/j.scr.2020.101800. Epub 2020 Apr 21. PMID: 32371361.
• Zhao H, Li S, He L, Han X, Huang H, Tang F, Lin Z, Deng S, Tian C, Huang R, Li Z. Generation of iPSC line (USTCi001-A) from human skin fibroblasts of a patient with epilepsy. Stem Cell Research. 2020 May;45:101785. doi: 10.1016/j.scr.2020.101785. Epub 2020 Apr 20. PMID: 32335389.
• He L, Zhao H, Li S, Han X, Chen Z, Wang C, Tian C, Tang F, Huang R, Lin Z, Li Z, Tang B, Jiang H. Generation of induced pluripotent stem cell line (CSUXHi002-A) from a patient with spinocerebellar ataxia type 1. Stem Cell Research. 2020 May;45:101816. doi: 10.1016/j.scr.2020.101816. Epub 2020 Apr 21. PMID: 32335388.
• Tariq M, Liu H, Ibañez DP, Li Y, Chen S, Jiang M, Fan W, Zhao P, Luo Z, Wang D, Kanwal S. Generation of three induced pluripotent stem cell lines from a Parkinson's disease patient with mutant PARKIN (p. C253Y). Stem Cell Research. 2020 May;45:101822. doi: 10.1016/j.scr.2020.101822. Epub 2020 Apr 24. PMID: 32387897.
• Chen S, Luo Z, Ward C, Ibañez DP, Liu H, Zhong X, Sharma NK, Qin B, Fan W, Wang D. Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9. Stem Cell Research. 2020 May;45:101804. doi: 10.1016/j.scr.2020.101804. Epub 2020 Apr 21. PMID: 32339904.
• Huang Q, Zhang X. Emerging Roles and Research Tools of Atypical Ubiquitination. Proteomics. 2020 May;20(9):e1900100. doi: 10.1002/pmic.201900100. Epub 2020 Jan 30. PMID: 31930661.
• Zhang K, Yu F, Zhu J, Han S, Chen J, Wu X, Chen Y, Shen T, Liao J, Guo W, Yang X, Wang R, Qian Y, Yang J, Cheng L, Zhao Y, Hui CC, Li J, Peng G, He S, Jing N, Tang K. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation. Cell Reports. 2020 Apr 21;31(3):107521. doi: 10.1016/j.celrep.2020.03.085. PMID: 32320667.
• Hou L, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, Yuan J, Tariq M, Li N, Sun H, Wang H, Zhang X, Chen J, Bao X, Jauch R. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Research. 2020 Apr 17;48(7):3869-3887. doi: 10.1093/nar/gkaa067. PMID: 32016422; PMCID: PMC7144947.
• Sun H, Yang X, Liang L, Zhang M, Li Y, Chen J, Wang F, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Lin L, Pei D, Zheng H. Metabolic switch and epithelial-mesenchymal transition cooperate to regulate pluripotency. EMBO Journal. 2020 Apr 15;39(8):e102961. doi: 10.15252/embj.2019102961. Epub 2020 Feb 24. PMID: 32090361; PMCID: PMC7156961.
• Yang L, Tang H, Lin X, Wu Y, Zeng S, Pan Y, Li Y, Xiang G, Lin YF, Zhuang SM, Song Z, Jiang Y, Liu X. OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion. Frontiers in Cell and Developmental Biology. 2020 Apr 9;8:180. doi: 10.3389/fcell.2020.00180. PMID: 32373606; PMCID: PMC7179665.
• Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H, Zheng H. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB Journal. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10. PMID: 32154623.
• Lakadamyali M, Cosma MP. Visualizing the genome in high resolution challenges our textbook understanding. Nature Methods. 2020 Apr;17(4):371-379. doi: 10.1038/s41592-020-0758-3. Epub 2020 Mar 2. PMID: 32123395.
• Peng R, Xu X, Jing J, Wang M, Peng Q, Liu S, Wu Y, Bao X, Wang P, Qi J, Gao GF, Shi Y. Structural insight into arenavirus replication machinery. Nature. 2020 Mar;579(7800):615-619. doi: 10.1038/s41586-020-2114-2. Epub 2020 Mar 18. PMID: 32214249.
• Liang L, Chen J, Li Y, Lai X, Sun H, Li C, Zhang M, Yang T, Meng F, Law PY, Loh HH, Zheng H. Morphine and Naloxone Facilitate Neural Stem Cells Proliferation via a TET1-Dependent and Receptor-Independent Pathway. Cell Reports. 2020 Mar 17;30(11):3625-3631.e6. doi: 10.1016/j.celrep.2020.02.075. PMID: 32187535.
• Xu Y, Liu H, Pan H, Wang X, Zhang Y, Yao B, Li N, Lai L, Li Z. CRISPR/Cas9-mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen. Genes. 2020 Mar 11;11(3):297. doi: 10.3390/genes11030297. PMID: 32168764; PMCID: PMC7140871.
• Xu Y, Wu Y, Xiong Y, Tao J, Pan T, Tan S, Gao G, Chen Y, Abbas N, Getachew A, Zhuang Y, You K, Yang F, Li YX. Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3). Nutrition & Metabolism. 2020 Mar 4;17:17. doi: 10.1186/s12986-020-0431-y. PMID: 32158492; PMCID: PMC7057613.
• Zhang Z, Zheng X, Sun W, Peng Y, Guo Y, Lu D, Zheng Y, Li X, Jendrichovsky P, Tang P, He L, Li M, Liu Q, Xu F, Ng G, Chen X, He J. Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts. Journal of Neuroscience. 2020 Mar 4;40(10):2025-2037. doi: 10.1523/JNEUROSCI.1673-19.2019. Epub 2020 Jan 24. PMID: 31980587; PMCID: PMC7055132.
• Zhou Y, Long Q, Wu H, Li W, Qi J, Wu Y, Xiang G, Tang H, Yang L, Chen K, Li L, Bao F, Li H, Wang Y, Li M, Liu X. Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy. 2020 Mar;16(3):562-574. doi: 10.1080/15548627.2019.1634944. Epub 2019 Jul 4. PMID: 31234709; PMCID: PMC6999642.
• Li Z, Cai Z, Fu W, Liu Y, Tian C, Wang H, Fu T, Wu Z, Wu D, Jin Y, Cheng Z, Terada N, Liu L, Wu W, Jin S, Bai F. High-efficiency protein delivery into transfection-recalcitrant cell types. Biotechnology and Bioengineering. 2020 Mar;117(3):816-831. doi: 10.1002/bit.27245. Epub 2019 Dec 20. PMID: 31814110.
• Shan W, Wang B, Xu Y, Li X, Li X, Wang H, Lin Y, Tie R, Zhao Q, Wang J, Zheng W, Hu Y, Shi J, Yu X, Huang H. Generation of hematopoietic cells from mouse pluripotent stem cells in a 3D culture system of self-assembling peptide hydrogel. Journal of Cellular Physiology. 2020 Mar;235(3):2080-2090. doi: 10.1002/jcp.29110. Epub 2019 Aug 6. PMID: 31389001.
• Kim HJ, Osteil P, Humphrey SJ, Cinghu S, Oldfield AJ, Patrick E, Wilkie EE, Peng G, Suo S, Jothi R, Tam PPL, Yang P. Transcriptional network dynamics during the progression of pluripotency revealed by integrative statistical learning. Nucleic Acids Research. 2020 Feb 28;48(4):1828-1842. doi: 10.1093/nar/gkz1179. PMID: 31853542; PMCID: PMC7038952.
• Ward C, Cauchy P, Garcia P, Frampton J, Esteban MA, Volpe G. High WBP5 expression correlates with elevation of HOX genes levels and is associated with inferior survival in patients with acute myeloid leukaemia. Scientific Reports. 2020 Feb 26;10(1):3505. doi: 10.1038/s41598-020-60480-x. Erratum in: Sci Rep. 2020 Jul 30;10(1):13109. PMID: 32103106; PMCID: PMC7044279.
• Ke M, Chong CM, Zeng H, Huang M, Huang Z, Zhang K, Cen X, Lu JH, Yao X, Qin D, Su H. Azoramide protects iPSC-derived dopaminergic neurons with PLA2G6 D331Y mutation through restoring ER function and CREB signaling. Cell Death & Disease. 2020 Feb 18;11(2):130. doi: 10.1038/s41419-020-2312-8. PMID: 32071291; PMCID: PMC7028918.
• Jiang J, Wang J, Yue M, Cai X, Wang T, Wu C, Su H, Wang Y, Han M, Zhang Y, Zhu X, Jiang P, Li P, Sun Y, Xiao W, Feng H, Qing G, Liu H. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis. Cancer Cell. 2020 Feb 10;37(2):200-215.e5. doi: 10.1016/j.ccell.2020.01.001. PMID: 32049046; PMCID: PMC7321798.
• George P, Dasyam N, Giunti G, Mester B, Bauer E, Andrews B, Perera T, Ostapowicz T, Frampton C, Li P, Ritchie D, Bollard CM, Hermans IF, Weinkove R. Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE). BMJ Open. 2020 Feb 9;10(2):e034629. doi: 10.1136/bmjopen-2019-034629. PMID: 32041862; PMCID: PMC7044946.
• Zhang S, Liu H, Amarsingh GV, Cheung CCH, Wu D, Narayanan U, Zhang L, Cooper GJS. Restoration of myocellular copper-trafficking proteins and mitochondrial copper enzymes repairs cardiac function in rats with diabetes-evoked heart failure. Metallomics. 2020 Feb 1;12(2):259-272. doi: 10.1039/c9mt00223e. Epub 2019 Dec 10. PMID: 31821401.
• Tian C, Huang R, Tang F, Lin Z, Cheng N, Han X, Li S, Zhou P, Deng S, Huang H, Zhao H, Xu J, Li Z. Transient Receptor Potential Ankyrin 1 Contributes to Lysophosphatidylcholine-Induced Intracellular Calcium Regulation and THP-1-Derived Macrophage Activation. Journal of Membrane Biology. 2020 Feb;253(1):43-55. doi: 10.1007/s00232-019-00104-2. Epub 2019 Dec 10. PMID: 31820013.
• Wu R, Luo S, Yang H, Hu X, Lin A, Pan G, Zhong X, Li Z. Transplantation of neural progenitor cells generated from human urine epithelial cell-derived induced pluripotent stem cells improves neurological functions in rats with stroke. Discovery Medicine. 2020 Jan-Feb;29(156):53-64. PMID: 32598863.
• Kanwal S, Guo X, Ward C, Volpe G, Qin B, Esteban MA, Bao X. Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency. Genomics Proteomics & Bioinformatics. 2020 Feb;18(1):16-25. doi: 10.1016/j.gpb.2019.06.003. Epub 2020 May 21. PMID: 32445708; PMCID: PMC7393543.
• Wu D, Lv J, Zhao R, Wu Z, Zheng D, Shi J, Lin S, Wang S, Wu Q, Long Y, Li P, Yao Y. PSCA is a target of chimeric antigen receptor T cells in gastric cancer. Biomarker Research. 2020 Jan 28;8:3. doi: 10.1186/s40364-020-0183-x. PMID: 32010446; PMCID: PMC6988264.
• Xu K, Yang L, Zhang L, Qi H. Lack of AKAP3 disrupts integrity of the subcellular structure and proteome of mouse sperm and causes male sterility. Development. 2020 Jan 22;147(2):dev181057. doi: 10.1242/dev.181057. PMID: 31969357.
• Shan Y, Zhang Y, Zhao Y, Wang T, Zhang J, Yao J, Ma N, Liang Z, Huang W, Huang K, Zhang T, Su Z, Chen Q, Zhu Y, Wu C, Zhou T, Sun W, Wei Y, Zhang C, Li C, Su S, Liao B, Zhong M, Zhong X, Nie J, Pei D, Pan G. JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells. Nature Communications. 2020 Jan 20;11(1):382. doi: 10.1038/s41467-019-14028-x. PMID: 31959746; PMCID: PMC6971254.
• Liu Z, Chen S, Shan H, Jia Y, Chen M, Song Y, Lai L, Li Z. Efficient base editing with high precision in rabbits using YFE-BE4max. Cell Death & Disease. 2020 Jan 20;11(1):36. doi: 10.1038/s41419-020-2244-3. PMID: 31959743; PMCID: PMC6971250.
• Guo R, Hu F, Weng Q, Lv C, Wu H, Liu L, Li Z, Zeng Y, Bai Z, Zhang M, Liu Y, Liu X, Xia C, Wang T, Zhou P, Wang K, Dong Y, Luo Y, Zhang X, Guan Y, Geng Y, Du J, Li Y, Lan Y, Chen J, Liu B, Wang J. Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research. 2020 Jan;30(1):21-33. doi: 10.1038/s41422-019-0251-7. Epub 2019 Nov 15. PMID: 31729468; PMCID: PMC6951346.
• Guo, Rongquna,b,c,d; Wu, Honglinga,b,c,d; Du, Juana,b,c,d; Wang, Jinyonga,b,c,d,e,∗ T cell regeneration: an update on progress and challenges, Blood Science: January 2020 - Volume 2 - Issue 1 - p 22-26 doi: 10.1097/BS9.0000000000000037
• Lu S, Zhang Z, Du P, Chard LS, Yan W, El Khouri M, Wang Z, Zhang Z, Chu Y, Gao D, Zhang Q, Zhang L, Nagano A, Wang J, Chelala C, Liu J, Chen J, Liu P, Dong Y, Wang S, Li X, Dong J, Lemoine NR, Pei D, Wang Y. A Virus-Infected, Reprogrammed Somatic Cell-Derived Tumor Cell (VIReST) Vaccination Regime Can Prevent Initiation and Progression of Pancreatic Cancer. Clinical Cancer Research. 2020 Jan 15;26(2):465-476. doi: 10.1158/1078-0432.CCR-19-1395. Epub 2019 Nov 25. Erratum in: Clin Cancer Res. 2021 May 1;27(9):2663. PMID: 31767564.
• 王秀芹,尹梦然,夏晴,王丽莎,秦宝明,姚红杰.RNA结合蛋白在多能干细胞命运转变中的研究进展.中国细胞生物学学报.2020,42(1):145-151
• Wu K, Liu H, Wang Y, He J, Xu S, Chen Y, Kuang J, Liu J, Guo L, Li D, Shi R, Shen L, Wang Y, Zhang X, Wang J, Pei D, Chen J. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Cell Reports. 2020 Jan 7;30(1):25-36.e6. doi: 10.1016/j.celrep.2019.12.010. PMID: 31914391.
• Liu Y, Zhang J, Chen Y, Sohel H, Ke X, Chen J, Li YX. The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis. Aging-US. 2020 Jan 5;12(1):204-223. doi: 10.18632/aging.102610. Epub 2020 Jan 5. PMID: 31905170; PMCID: PMC6977693.
• Chen K, Long Q, Xing G, Wang T, Wu Y, Li L, Qi J, Zhou Y, Ma B, Schöler HR, Nie J, Pei D, Liu X. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal. 2020 Jan 2;39(1):e99165. doi: 10.15252/embj.201899165. Epub 2019 Oct 1. PMID: 31571238; PMCID: PMC6939195.
• Liu Z, Shan H, Chen S, Chen M, Song Y, Lai L, Li Z. Highly efficient base editing with expanded targeting scope using SpCas9-NG in rabbits. FASEB Journal. 2020 Jan;34(1):588-596. doi: 10.1096/fj.201901587R. Epub 2019 Nov 26. PMID: 31914687.

重要文章

• Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, Duan L, Liu X. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv. 2019 Nov 27;5(11):eaax7525. doi: 10.1126/sciadv.aax7525. PMID: 31807705; PMCID: PMC6881163.(发现磷脂调控多能干细胞命运的全新“烽燧”模式)
• Peng G, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ, Jing N. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019 Aug;572(7770):528-532. doi: 10.1038/s41586-019-1469-8. Epub 2019 Aug 7. Erratum in: Nature. 2020 Jan;577(7791):E6. Erratum in: Nature. 2020 Oct;586(7827):E7. PMID: 31391582.（系统揭示了小鼠原肠胚发育阶段的原位转录组表达谱，从发育时间和胚胎组织三维空间共四个维度阐述了谱系特化过程中的分子调控规律以及多能性转变过程）
• Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019 Aug 2;10(1):3477. doi: 10.1038/s41467-019-11054-7. PMID: 31375664; PMCID: PMC6677745.（揭示了转录因子诱导的体细胞多能性重编程的起始分子机制）
• Xie J, Ge W, Li N, Liu Q, Chen F, Yang X, Huang X, Ouyang Z, Zhang Q, Zhao Y, Liu Z, Gou S, Wu H, Lai C, Fan N, Jin Q, Shi H, Liang Y, Lan T, Quan L, Li X, Wang K, Lai L. Efficient base editing for multiple genes and loci in pigs using base editors. Nat Commun. 2019 Jun 28;10(1):2852. doi: 10.1038/s41467-019-10421-8. PMID: 31253764; PMCID: PMC6599043.（首次在猪上实现多位点单碱基编辑）
• Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen YS, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang YG, Yao H. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nat Commun. 2019 Apr 4;10(1):1535. doi: 10.1038/s41467-019-08949-w. PMID: 30948729; PMCID: PMC6449404.（揭示染色质高级结构变化调控细胞凋亡的新机制）
• Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G, Ji H, Zhou B. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet. 2019 Apr;51(4):728-738. doi: 10.1038/s41588-019-0346-6. Epub 2019 Feb 18. Erratum in: Nat Genet. 2019 Mar 7;: PMID: 30778223.（证实了人体中存在一种参与肺脏再生的“按需分化”、“跨界维修”的肺多能干细胞）
• Guo L, Lin L, Wang X, Gao M, Cao S, Mai Y, Wu F, Kuang J, Liu H, Yang J, Chu S, Song H, Li D, Liu Y, Wu K, Liu J, Wang J, Pan G, Hutchins AP, Liu J, Pei D, Chen J. Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. Mol Cell. 2019 Feb 21;73(4):815-829.e7. doi: 10.1016/j.molcel.2019.01.042. Epub 2019 Feb 13. PMID: 30772174.（单细胞测序解析体细胞重编程路径）
• He J, Fu X, Zhang M, He F, Li W, Abdul MM, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nat Commun. 2019 Jan 3;10(1):34. doi: 10.1038/s41467-018-08006-y. PMID: 30604769; PMCID: PMC6318327.（阐明基因组中转座元件的关键调控机制）

所有文章

• Cui G, Jing N, Peng G. Comments on 'Molecular architecture of lineage allocation and tissue organization in early mouse embryo'. J Mol Cell Biol. 2019 Dec 23;11(11):1024-1025. doi: 10.1093/jmcb/mjz101. PMID: 31599945; PMCID: PMC6927235.
• Bredenkamp N, Yang J, Clarke J, Stirparo GG, von Meyenn F, Dietmann S, Baker D, Drummond R, Ren Y, Li D, Wu C, Rostovskaya M, Eminli-Meissner S, Smith A, Guo G. Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency. Stem Cell Reports. 2019 Dec 10;13(6):1083-1098. doi: 10.1016/j.stemcr.2019.10.009. Epub 2019 Nov 7. PMID: 31708477; PMCID: PMC6915845.
• Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H, Wang H. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun. 2019 Dec 19;10(1):5787. doi: 10.1038/s41467-019-13598-0. PMID: 31857580; PMCID: PMC6923398.
• Liu Z, Shan H, Chen S, Chen M, Song Y, Lai L, Li Z. Efficient base editing with expanded targeting scope using an engineered Spy-mac Cas9 variant. Cell Discov. 2019 Dec 3;5:58. doi: 10.1038/s41421-019-0128-4. PMID: 31814995; PMCID: PMC6888851.
• Pan T, Chen Y, Zhuang Y, Yang F, Xu Y, Tao J, You K, Wang N, Wu Y, Lin X, Wu F, Liu Y, Li Y, Wang G, Li YX. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. Stem Cell Res Ther. 2019 Dec 2;10(1):364. doi: 10.1186/s13287-019-1463-y. PMID: 31791391; PMCID: PMC6888929.
• Zhang M, Ibañez DP, Fan W, Liu H, Zhong X, Wang X, Li Y, Md Abdul M, Li W, Li Y, Ward C, Chen S, Wang D, Qin B, Esteban MA, Zhao P, Luo Z. Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished. Stem Cell Res. 2019 Dec;41:101602. doi: 10.1016/j.scr.2019.101602. Epub 2019 Oct 15. PMID: 31698191.
• Abdul MM, Ibañez DP, Zhao P, Liu H, Zhong X, Li Y, Zhang M, Li W, Li Y, Ward C, Chen S, Wang D, Qin B, Esteban MA, Wang X, Fan W, Luo Z. Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N). Stem Cell Res. 2019 Dec;41:101607. doi: 10.1016/j.scr.2019.101607. Epub 2019 Oct 15. PMID: 31778937.
• Lau ST, Li Z, Pui-Ling Lai F, Nga-Chu Lui K, Li P, Munera JO, Pan G, Mahe MM, Hui CC, Wells JM, Ngan ES. Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses. Gastroenterology. 2019 Dec;157(6):1556-1571.e5. doi: 10.1053/j.gastro.2019.08.019. Epub 2019 Aug 20. PMID: 31442438.
• Liu Z, Yao M, Yao H, Hu G, Qin B. Generation of Rybp homozygous knockout murine ES cell line GIBHe001-A-1 by using CRISPR/Cas9 technology. Stem Cell Res. 2019 Dec;41:101638. doi: 10.1016/j.scr.2019.101638. Epub 2019 Oct 26. PMID: 31794887.
• Xiao L, Shan Y, Ma L, Dunk C, Yu Y, Wei Y. Tuning FOXD3 expression dose-dependently balances human embryonic stem cells between pluripotency and meso-endoderm fates. Biochim Biophys Acta Mol Cell Res. 2019 Dec;1866(12):118531. doi: 10.1016/j.bbamcr.2019.118531. Epub 2019 Aug 12. PMID: 31415841.
• Yang X, Liu Y, Zhou T, Zhang H, Dong R, Li Y, Liu N, Liu Y, Gai Z. An induced pluripotent stem cells line (SDQLCHi014-A) derived from urine cells of a patient with ASD and hyperactivity carrying a 303 kb de novo deletion at chr3p26.1 implicating GRM7 gene. Stem Cell Res. 2019 Dec;41:101635. doi: 10.1016/j.scr.2019.101635. Epub 2019 Nov 2. PMID: 31707215.
• Zhang J, Wei L, Chen D, Feng L, Wu C, Wang R, Li X. Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi003-A) from a Wilson's disease patient harboring a homozygous R778L mutation in ATP7B gene. Stem Cell Res. 2019 Dec;41:101664. doi: 10.1016/j.scr.2019.101664. Epub 2019 Nov 21. PMID: 31783295.
• Wu Y, Chen K, Xing G, Li L, Ma B, Hu Z, Duan L, Liu X. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Sci Adv. 2019 Nov 27;5(11):eaax7525. doi: 10.1126/sciadv.aax7525. PMID: 31807705; PMCID: PMC6881163.
• Zeng Y, Liu C, Gong Y, Bai Z, Hou S, He J, Bian Z, Li Z, Ni Y, Yan J, Huang T, Shi H, Ma C, Chen X, Wang J, Bian L, Lan Y, Liu B, Hu H. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019 Nov 19;51(5):930-948.e6. doi: 10.1016/j.immuni.2019.09.008. Epub 2019 Oct 8. PMID: 31604687.
• Niu Y, Sun N, Li C, Lei Y, Huang Z, Wu J, Si C, Dai X, Liu C, Wei J, Liu L, Feng S, Kang Y, Si W, Wang H, Zhang E, Zhao L, Li Z, Luo X, Cui G, Peng G, Izpisúa Belmonte JC, Ji W, Tan T. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science. 2019 Nov 15;366(6467):eaaw5754. doi: 10.1126/science.aaw5754. Epub 2019 Oct 31. PMID: 31672917.
• Xu G, Wu F, Gu X, Zhang J, You K, Chen Y, Getachew A, Zhuang Y, Zhong X, Lin Z, Guo D, Yang F, Pan T, Wei H, Li YX. Direct Conversion of Human Urine Cells to Neurons by Small Molecules. Sci Rep. 2019 Nov 13;9(1):16707. doi: 10.1038/s41598-019-53007-6. PMID: 31723223; PMCID: PMC6854089.
• Yang X, Hu B, Liao J, Qiao Y, Chen Y, Qian Y, Feng S, Yu F, Dong J, Hou Y, Xu H, Wang R, Peng G, Li J, Tang F, Jing N. Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development. Cell Res. 2019 Nov;29(11):911-926. doi: 10.1038/s41422-019-0234-8. Epub 2019 Oct 7. PMID: 31591447; PMCID: PMC6889293.
• Zhong X, Li H, Kim J, Chang Q. Regulation of neural differentiation, synaptic scaling and animal behavior by MeCP2 phophorylation. Neurobiol Learn Mem. 2019 Nov;165:106859. doi: 10.1016/j.nlm.2018.04.014. Epub 2018 Apr 24. PMID: 29698767; PMCID: PMC6200650.
• Shi Z, Xu S, Xing S, Yao K, Zhang L, Xue L, Zhou P, Wang M, Yan G, Yang P, Liu J, Hu Z, Lan F. Mettl17, a regulator of mitochondrial ribosomal RNA modifications, is required for the translation of mitochondrial coding genes. FASEB J. 2019 Nov;33(11):13040-13050. doi: 10.1096/fj.201901331R. Epub 2019 Sep 5. PMID: 31487196.
• Wang P, Xia J, Zhang L, Zhao S, Li S, Wang H, Cheng S, Li H, Yin W, Pei D, Shu X. SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis. Cells. 2019 Oct 29;8(11):1335. doi: 10.3390/cells8111335. PMID: 31671755; PMCID: PMC6912348.
• Lv Y, Tariq M, Guo X, Kanwal S, Esteban MA. Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation. J Mol Cell Biol. 2019 Oct 25;11(10):813-815. doi: 10.1093/jmcb/mjz089. PMID: 31504662; PMCID: PMC6884707.
• Zhou Y, Wang X, Song M, He Z, Cui G, Peng G, Dieterich C, Antebi A, Jing N, Shen Y. A secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing. Nat Commun. 2019 Oct 23;10(1):4827. doi: 10.1038/s41467-019-12821-2. PMID: 31645592; PMCID: PMC6811558.
• Lian YF, Huang YL, Zhang YJ, Chen DM, Wang JL, Wei H, Bi YH, Jiang ZW, Li P, Chen MS, Huang YH. CACYBP Enhances Cytoplasmic Retention of P27Kip1 to Promote Hepatocellular Carcinoma Progression in the Absence of RNF41 Mediated Degradation. Theranostics. 2019 Oct 22;9(26):8392-8408. doi: 10.7150/thno.36838. PMID: 31754404; PMCID: PMC6857042.
• Frade J, Nakagawa S, Cortes P, di Vicino U, Romo N, Lluis F, Cosma MP. Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development. Sci Adv. 2019 Oct 16;5(10):eaax4199. doi: 10.1126/sciadv.aax4199. PMID: 31663024; PMCID: PMC6795515.
• Suen HC, Qian Y, Liao J, Luk CS, Lee WT, Ng JKW, Chan TTH, Hou HW, Li I, Li K, Chan WY, Feng B, Gao L, Jiang X, Liu YH, Rudd JA, Hobbs R, Qi H, Ng TK, Mak HK, Leung KS, Lee TL. Transplantation of Retinal Ganglion Cells Derived from Male Germline Stem Cell as a Potential Treatment to Glaucoma. Stem Cells Dev. 2019 Oct 15;28(20):1365-1375. doi: 10.1089/scd.2019.0060. Epub 2019 Oct 3. PMID: 31580778.
• Pedone E, Postiglione L, Aulicino F, Rocca DL, Montes-Olivas S, Khazim M, di Bernardo D, Pia Cosma M, Marucci L. A tunable dual-input system for on-demand dynamic gene expression regulation. Nat Commun. 2019 Oct 2;10(1):4481. doi: 10.1038/s41467-019-12329-9. PMID: 31578371; PMCID: PMC6775159.
• Tan Y, Ke M, Huang Z, Chong CM, Cen X, Lu JH, Yao X, Qin D, Su H. Hydroxyurea Facilitates Manifestation of Disease Relevant Phenotypes in Patients-Derived IPSCs-Based Modeling of Late-Onset Parkinson's Disease. Aging Dis. 2019 Oct 1;10(5):1037-1048. doi: 10.14336/AD.2018.1216. PMID: 31595201; PMCID: PMC6764725.
• Liu Z, Chen M, Shan H, Chen S, Xu Y, Song Y, Zhang Q, Yuan H, Ouyang H, Li Z, Lai L. Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7). Cell Mol Life Sci. 2019 Oct;76(20):4155-4164. doi: 10.1007/s00018-019-03110-8. Epub 2019 Apr 27. PMID: 31030226.
• Sun W, Zhao X, Wang Z, Chu Y, Mao L, Lin S, Gao X, Song Y, Hui X, Jia S, Tang S, Xu Y, Xu A, Loomes K, Wang C, Wu D, Nie T. Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway. Mol Metab. 2019 Oct;28:48-57. doi: 10.1016/j.molmet.2019.07.004. Epub 2019 Jul 5. PMID: 31352005; PMCID: PMC6822144.
• Li S, Zhao H, Huang R, He L, Tian C, Huang H, Han X, Tang F, Lin Z, Deng S, Zhou J, Li Z. Generation of iPSC line (GIBHi001-A) from a patient with autism spectrum disorder. Stem Cell Res. 2019 Oct;40:101571. doi: 10.1016/j.scr.2019.101571. Epub 2019 Sep 6. PMID: 31520889.
• Li L, Meng H, Zou Q, Zhang J, Cai L, Yang B, Weng J, Lai L, Yang H, Gao Y. Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use. J Gastroenterol Hepatol. 2019 Oct;34(10):1851-1859. doi: 10.1111/jgh.14666. Epub 2019 Apr 10. PMID: 30884543.
• Yang X, Zhou T, Zhang H, Li Y, Dong R, Liu N, Pan G, Liu Y, Gai Z. Generation of an induced pluripotent stem cell line (SDQLCHi008-A) from a patient with ASD and DD carrying an 830 kb de novo deletion at chr7q11.22 including the exon 1 of AUTS2 gene. Stem Cell Res. 2019 Oct;40:101557. doi: 10.1016/j.scr.2019.101557. Epub 2019 Aug 31. PMID: 31505389.
• He L, Ye W, Chen Z, Wang C, Zhao H, Li S, Peng L, Han X, Zhou T, Li Z, Tang B, Jiang H. Generation of an induced pluripotent stem cell line (XHCSUi001-A) from urine cells of a patient with spinocerebellar ataxia type 3. Stem Cell Res. 2019 Oct;40:101555. doi: 10.1016/j.scr.2019.101555. Epub 2019 Aug 27. Erratum in: Stem Cell Res. 2020 Mar;43:101715. PMID: 31491691.
• Ma Y, Zhang H, Yang X, Li Y, Guan J, Zhang K, Huang Y, Pan G, Gai Z, Liu Y. Generation of two induced pluripotent stem cell lines from patients with unbalanced translocation (3;22). Stem Cell Res. 2019 Oct;40:101545. doi: 10.1016/j.scr.2019.101545. Epub 2019 Aug 21. PMID: 31472451.
• Otterstrom J, Castells-Garcia A, Vicario C, Gomez-Garcia PA, Cosma MP, Lakadamyali M. Super-resolution microscopy reveals how histone tail acetylation affects DNA compaction within nucleosomes in vivo. Nucleic Acids Res. 2019 Sep 19;47(16):8470-8484. doi: 10.1093/nar/gkz593. PMID: 31287868; PMCID: PMC6895258.
• Zhang T, Huang K, Zhu Y, Wang T, Shan Y, Long B, Li Y, Chen Q, Wang P, Zhao S, Li D, Wu C, Kang B, Gu J, Mai Y, Wang Q, Li J, Zhang Y, Liang Z, Guo L, Wu F, Su S, Wang J, Gao M, Zhong X, Liao B, Chen J, Zhang X, Shu X, Pei D, Nie J, Pan G. Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition. J Biol Chem. 2019 Sep 13;294(37):13657-13670. doi: 10.1074/jbc.RA119.009757. Epub 2019 Jul 24. PMID: 31341023; PMCID: PMC6746450.
• Li G, Gao G, Wang P, Song X, Xu P, Xie B, Zhou T, Pan G, Peng F, Zhang Q, Ge J, Zhong X. Generation and Characterization of Induced Pluripotent Stem Cells and Retinal Organoids From a Leber's Congenital Amaurosis Patient With Novel RPE65 Mutations. Front Mol Neurosci. 2019 Sep 11;12:212. doi: 10.3389/fnmol.2019.00212. PMID: 31572124; PMCID: PMC6749091.
• Wang F, Cheng N, Chen J, Yang Y, Huang R, Huang H, Lin Z, Tian C, Zhao H, Long Y, Li Z. Promoting Osteogenesis of Human Umbilical Cord Mesenchymal Stem Cells Using 1α, 25-(OH)₂D₃ to Change Intracellular Calcium Concentration. J Nanosci Nanotechnol. 2019 Sep 1;19(9):5435-5440. doi: 10.1166/jnn.2019.16509. PMID: 30961693.
• Yang Y, Liu S, Lei Z, Chen G, Huang L, Yang F, Lei Y, Liu Y, Yang L, Liu W, Lai L, Guo J. Circular RNA profile in liver tissue of EpCAM knockout mice. Int J Mol Med. 2019 Sep;44(3):1063-1077. doi: 10.3892/ijmm.2019.4270. Epub 2019 Jul 8. PMID: 31524221; PMCID: PMC6657977.
• Lu Y, Liang M, Zhang Q, Liu Z, Song Y, Lai L, Li Z. Mutations of GADD45G in rabbits cause cleft lip by the disorder of proliferation, apoptosis and epithelial-mesenchymal transition (EMT). Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2356-2367. doi: 10.1016/j.bbadis.2019.05.015. Epub 2019 May 29. PMID: 31150757.
• Shah Z, Nazir S, Mazhar K, Abbasi R, Samokhvalov IM. PEGylated doped- and undoped-TiO2 nanoparticles for photodynamic Therapy of cancers. Photodiagnosis Photodyn Ther. 2019 Sep;27:173-183. doi: 10.1016/j.pdpdt.2019.05.019. Epub 2019 May 25. PMID: 31136827.
• Zhang S, Wang Y, Jia L, Wen X, Du Z, Wang C, Hao Y, Yu D, Zhou L, Chen N, Chen J, Chen H, Zhang H, Celik I, Gülsoy G, Luo J, Qin B, Cui X, Liu Z, Zhang S, Esteban MA, Ay F, Xu W, Chen R, Li W, Hoffman AR, Hu JF, Cui J. Profiling the long noncoding RNA interaction network in the regulatory elements of target genes by chromatin in situ reverse transcription sequencing. Genome Res. 2019 Sep;29(9):1521-1532. doi: 10.1101/gr.244996.118. Epub 2019 Jul 17. PMID: 31315906; PMCID: PMC6724666.
• Wang H, Chen J, Xu X, Sun WJ, Chen X, Zhao F, Luo MH, Liu C, Guo Y, Xie W, Zhong H, Bai T, Tian Y, Mao Y, Ye C, Tao W, Li J, Farzinpour Z, Li J, Zhou JN, Wang K, He J, Chen L, Zhang Z. Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior. PLoS Biol. 2019 Aug 30;17(8):e3000417. doi: 10.1371/journal.pbio.3000417. PMID: 31469831; PMCID: PMC6742420.
• Lv J, Li P. Mesothelin as a biomarker for targeted therapy.Biomark Res. 2019 Aug 23;7:18. doi: 10.1186/s40364-019-0169-8. PMID: 31463062; PMCID: PMC6708176.
• Dong Y, Xia C, Weng Q, Wang T, Hu F, Wang K, Liu X, Geng Y, Liu L, Wu H, Du J. Synergy of NUP98-HOXA10 Fusion Gene and NrasG12D Mutation Preserves the Stemness of Hematopoietic Stem Cells on Culture Condition. Cells. 2019 Aug 22;8(9):951. doi: 10.3390/cells8090951. PMID: 31443434; PMCID: PMC6770072.
• Wang L, Xu X, Jiang C, Ma G, Huang Y, Zhang H, Lai Y, Wang M, Ahmed T, Lin R, Guo W, Luo Z, Li W, Zhang M, Ward C, Qian M, Liu B, Esteban MA, Qin B. mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. FEBS J. 2020 Jan;287(1):108-121. doi: 10.1111/febs.15024. Epub 2019 Aug 18. PMID: 31361392.
• Peng G, Suo S, Cui G, Yu F, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ, Jing N. Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature. 2019 Aug;572(7770):528-532. doi: 10.1038/s41586-019-1469-8. Epub 2019 Aug 7. Erratum in: Nature. 2020 Jan;577(7791):E6. Erratum in: Nature. 2020 Oct;586(7827):E7. PMID: 31391582.
• Malik V, Glaser LV, Zimmer D, Velychko S, Weng M, Holzner M, Arend M, Chen Y, Srivastava Y, Veerapandian V, Shah Z, Esteban MA, Wang H, Chen J, Schöler HR, Hutchins AP, Meijsing SH, Pott S, Jauch R. Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2. Nat Commun. 2019 Aug 2;10(1):3477. doi: 10.1038/s41467-019-11054-7. PMID: 31375664; PMCID: PMC6677745.
• Li S, Shen L, Huang L, Lei S, Cai X, Breitzig M, Zhang B, Yang A, Ji W, Huang M, Zheng Q, Sun H, Wang F. PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells. Biochim Biophys Acta Gene Regul Mech. 2019 Aug;1862(8):858-869. doi: 10.1016/j.bbagrm.2019.04.006. Epub 2019 May 7. PMID: 31075540.
• Sun SC, Ma D, Li MY, Zhang RX, Huang C, Huang HJ, Xie YZ, Wang ZJ, Liu J, Cai DC, Liu CX, Yang Q, Bao FX, Gong XL, Li JR, Hui Z, Wei XF, Zhong JM, Zhou WJ, Shang X, Zhang C, Liu XG, Tang BS, Xiong F, Xu XM. Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease. Brain. 2019 Aug 1;142(8):2215-2229. doi: 10.1093/brain/awz151. Erratum in: Brain. 2019 Oct 1;142(10):e56. PMID: 31199454.
• Lin YF, Xiao MH, Chen HX, Meng Y, Zhao N, Yang L, Tang H, Wang JL, Liu X, Zhu Y, Zhuang SM. A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation. Cell Death Dis. 2019 Jul 11;10(7):528. doi: 10.1038/s41419-019-1767-y. PMID: 31296841; PMCID: PMC6624212.
• Schmidt L, Heyes E, Scheiblecker L, Eder T, Volpe G, Frampton J, Nerlov C, Valent P, Grembecka J, Grebien F. CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex. Leukemia. 2019 Jul;33(7):1608-1619. doi: 10.1038/s41375-019-0382-3. Epub 2019 Jan 24. PMID: 30679799; PMCID: PMC6612510.
• Xie J, Ge W, Li N, Liu Q, Chen F, Yang X, Huang X, Ouyang Z, Zhang Q, Zhao Y, Liu Z, Gou S, Wu H, Lai C, Fan N, Jin Q, Shi H, Liang Y, Lan T, Quan L, Li X, Wang K, Lai L. Efficient base editing for multiple genes and loci in pigs using base editors. Nat Commun. 2019 Jun 28;10(1):2852. doi: 10.1038/s41467-019-10421-8. PMID: 31253764; PMCID: PMC6599043.
• Wang B, Wu L, Li D, Liu Y, Guo J, Li C, Yao Y, Wang Y, Zhao G, Wang X, Fu M, Liu H, Cao S, Wu C, Yu S, Zhou C, Qin Y, Kuang J, Ming J, Chu S, Yang X, Zhu P, Pan G, Chen J, Liu J, Pei D. Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4. Cell Rep. 2019 Jun 18;27(12):3473-3485.e5. doi: 10.1016/j.celrep.2019.05.068. PMID: 31216469.
• Liu Z, Chen S, Shan H, Zhang Q, Chen M, Lai L, Li Z. Efficient and precise base editing in rabbits using human APOBEC3A-nCas9 fusions. Cell Discov. 2019 Jun 11;5:31. doi: 10.1038/s41421-019-0099-5. PMID: 31231541; PMCID: PMC6557807.
• Shen L, Lei S, Huang L, Li S, Yi S, Breitzig M, Huang M, Mo X, Sun H, Zheng Q, Tian J, Czachor A, Wang F. Therapeutic effects of the rhSOD2-Hirudin fusion protein on bleomycin-induced pulmonary fibrosis in mice. Eur J Pharmacol. 2019 Jun 5;852:77-89. doi: 10.1016/j.ejphar.2019.03.001. Epub 2019 Mar 2. PMID: 30831079.
• Sundararajan V, Tan M, Tan TZ, Ye J, Thiery JP, Huang RY. SNAI1 recruits HDAC1 to suppress SNAI2 transcription during epithelial to mesenchymal transition. Sci Rep. 2019 Jun 5;9(1):8295. doi: 10.1038/s41598-019-44826-8. PMID: 31165775; PMCID: PMC6549180.
• Gao X, Nowak-Imialek M, Chen X, Chen D, Herrmann D, Ruan D, Chen ACH, Eckersley-Maslin MA, Ahmad S, Lee YL, Kobayashi T, Ryan D, Zhong J, Zhu J, Wu J, Lan G, Petkov S, Yang J, Antunes L, Campos LS, Fu B, Wang S, Yong Y, Wang X, Xue SG, Ge L, Liu Z, Huang Y, Nie T, Li P, Wu D, Pei D, Zhang Y, Lu L, Yang F, Kimber SJ, Reik W, Zou X, Shang Z, Lai L, Surani A, Tam PPL, Ahmed A, Yeung WSB, Teichmann SA, Niemann H, Liu P. Establishment of porcine and human expanded potential stem cells. Nat Cell Biol. 2019 Jun;21(6):687-699. doi: 10.1038/s41556-019-0333-2. Epub 2019 Jun 3. PMID: 31160711; PMCID: PMC7035105.
• Liu T, Wang J, Xie X, Wang K, Sui T, Liu D, Lai L, Zhao H, Li Z, Feng JQ. DMP1 Ablation in the Rabbit Results in Mineralization Defects and Abnormalities in Haversian Canal/Osteon Microarchitecture. J Bone Miner Res. 2019 Jun;34(6):1115-1128. doi: 10.1002/jbmr.3683. Epub 2019 Mar 3. PMID: 30827034.
• Yu S, Wang D, Huang L, Zhang Y, Luo R, Adah D, Tang Y, Zhao K, Lu B. The complement receptor C5aR2 promotes protein kinase R expression and contributes to NLRP3 inflammasome activation and HMGB1 release from macrophages. J Biol Chem. 2019 May 24;294(21):8384-8394. doi: 10.1074/jbc.RA118.006508. Epub 2019 Apr 10. PMID: 30971430; PMCID: PMC6544858.
• Antony J, Thiery JP, Huang RY. Epithelial-to-mesenchymal transition: lessons from development, insights into cancer and the potential of EMT-subtype based therapeutic intervention. Phys Biol. 2019 May 7;16(4):041004. doi: 10.1088/1478-3975/ab157a. PMID: 30939460.
• Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M. Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. Stem Cell Res. 2019 May;37:101431. doi: 10.1016/j.scr.2019.101431. Epub 2019 Mar 27. PMID: 30974404.
• Mura M, Lee YK, Pisano F, Ginevrino M, Boni M, Calabrò F, Crotti L, Valente EM, Schwartz PJ, Tse HF, Gnecchi M. Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation. Stem Cell Res. 2019 May;37:101437. doi: 10.1016/j.scr.2019.101437. Epub 2019 Apr 13. PMID: 31009818.
• Zhao J, Lai L, Ji W, Zhou Q. Genome editing in large animals: current status and future prospects. Nat Sci Rev. 2019 May; 6(3), 402–420. doi: 10.1093/nsr/nwz013/5304991 by guest on 05 February 2019
• Siddiqi FH, Menzies FM, Lopez A, Stamatakou E, Karabiyik C, Ureshino R, Ricketts T, Jimenez-Sanchez M, Esteban MA, Lai L, Tortorella MD, Luo Z, Liu H, Metzakopian E, Fernandes HJR, Bassett A, Karran E, Miller BL, Fleming A, Rubinsztein DC. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.Nat Commun. 2019 Apr 18;10(1):1817. doi: 10.1038/s41467-019-09494-2. Erratum in: Nat Commun. 2019 Jun 4;10(1):2530. PMID: 31000720; PMCID: PMC6472390.
• Li J, Huang K, Hu G, Babarinde IA, Li Y, Dong X, Chen YS, Shang L, Guo W, Wang J, Chen Z, Hutchins AP, Yang YG, Yao H. An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis. Nat Commun. 2019 Apr 4;10(1):1535. doi: 10.1038/s41467-019-08949-w. PMID: 30948729; PMCID: PMC6449404.
• Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, Wu D, Hui X, Nie T. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sci. 2019 Apr 1;222:117-124. doi: 10.1016/j.lfs.2019.01.047. Epub 2019 Jan 29. PMID: 30708100.
• Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G, Ji H, Zhou B. Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet. 2019 Apr;51(4):728-738. doi: 10.1038/s41588-019-0346-6. Epub 2019 Feb 18. Erratum in: Nat Genet. 2019 Mar 7;: PMID: 30778223.
• Chen X, Li X, Wong YT, Zheng X, Wang H, Peng Y, Feng H, Feng J, Baibado JT, Jesky R, Wang Z, Xie H, Sun W, Zhang Z, Zhang X, He L, Zhang N, Zhang Z, Tang P, Su J, Hu LL, Liu Q, He X, Tan A, Sun X, Li M, Wong K, Wang X, Cheung HY, Shum DK, Yung KKL, Chan YS, Tortorella M, Guo Y, Xu F, He J. Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6397-6406. doi: 10.1073/pnas.1816833116. Epub 2019 Mar 8. PMID: 30850520; PMCID: PMC6442640.
• Volpe G, Cauchy P, Walton DS, Ward C, Blakemore D, Bayley R, Clarke ML, Schmidt L, Nerlov C, Garcia P, Dumon S, Grebien F, Frampton J. Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations. Life Sci Alliance. 2019 Mar 15;2(2):e201800207. doi: 10.26508/lsa.201800207. PMID: 30877232; PMCID: PMC6421631.
• Liao S, Zhang Y, Ting S, Zhen Z, Luo F, Zhu Z, Jiang Y, Sun S, Lai WH, Lian Q, Tse HF. Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure. Stem Cell Res Ther. 2019 Mar 7;10(1):78. doi: 10.1186/s13287-019-1183-3. PMID: 30845990; PMCID: PMC6407247.
• Cheng S, Pei Y, He L, Peng G, Reinius B, Tam PPL, Jing N, Deng Q. Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development. Cell Rep. 2019 Mar 5;26(10):2593-2607.e3. doi: 10.1016/j.celrep.2019.02.031. PMID: 30840884.
• Xing Q, Lin A, Su Z, Liu C, Huang W, Guo W, Pan G, Guo Y, Zhong X. Retrograde monosynaptic tracing through an engineered human embryonic stem cell line reveals synaptic inputs from host neurons to grafted cells. Cell Regen. 2019 Mar 1;8(1):1-8. doi: 10.1016/j.cr.2019.01.002. PMID: 31205682; PMCID: PMC6557763.
• Song W, Wang R, Jiang W, Yin Q, Peng G, Yang R, Yu QC, Chen J, Li J, Cheung TH, Jing N, Zeng YA. Hormones induce the formation of luminal-derived basal cells in the mammary gland. Cell Res. 2019 Mar;29(3):206-220. doi: 10.1038/s41422-018-0137-0. Epub 2019 Jan 10. Erratum in: Cell Res. 2019 Feb 26;:. Li, Jingsong [corrected to Li, Jinsong]. PMID: 30631153; PMCID: PMC6460434.
• Tan TZ, Rouanne M, Tan KT, Huang RY, Thiery JP. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol. 2019 Mar;75(3):423-432. doi: 10.1016/j.eururo.2018.08.027. Epub 2018 Sep 10. PMID: 30213523.
• Wei R, Han H, Ye M, He L, Lei Q, Zhou T, Cai X, Li Z. Generation of an integration-free iPSC line(SYSUi001-A) from a sporadic Alzheimer's disease patient. Stem Cell Res. 2019 Mar;35:101375. doi: 10.1016/j.scr.2018.101375. Epub 2018 Dec 18. PMID: 30797990.
• Guo L, Lin L, Wang X, Gao M, Cao S, Mai Y, Wu F, Kuang J, Liu H, Yang J, Chu S, Song H, Li D, Liu Y, Wu K, Liu J, Wang J, Pan G, Hutchins AP, Liu J, Pei D, Chen J. Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. Mol Cell. 2019 Feb 21;73(4):815-829.e7. doi: 10.1016/j.molcel.2019.01.042. Epub 2019 Feb 13. PMID: 30772174.
• Lv J, Zhao R, Wu D, Zheng D, Wu Z, Shi J, Wei X, Wu Q, Long Y, Lin S, Wang S, Wang Z, Li Y, Chen Y, He Q, Chen S, Yao H, Liu Z, Tang Z, Yao Y, Pei D, Liu P, Zhang X, Zhang Z, Cui S, Chen R, Li P. Mesothelin is a target of chimeric antigen receptor T cells for treating gastric cancer. J Hematol Oncol. 2019 Feb 18;12(1):18. doi: 10.1186/s13045-019-0704-y. PMID: 30777106; PMCID: PMC6380000.
• Tu Z, Zhao H, Li B, Yan S, Wang L, Tang Y, Li Z, Bai D, Li C, Lin Y, Li Y, Liu J, Xu H, Guo X, Jiang YH, Zhang YQ, Li XJ. CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms. Hum Mol Genet. 2019 Feb 15;28(4):561-571. doi: 10.1093/hmg/ddy367. PMID: 30329048; PMCID: PMC6489410.
• He S, Wang F, Zhang Y, Chen J, Liang L, Li Y, Zhang M, Yang X, Pang H, Li Y, Huang X, Qin D, Pei D, Sun H, Zheng H. Hemi-methylated CpG sites connect Dnmt1-knockdown-induced and Tet1-induced DNA demethylation during somatic cell reprogramming. Cell Discov. 2019 Feb 12;5:11. doi: 10.1038/s41421-018-0074-6. PMID: 30774978; PMCID: PMC6370818.
• Luo Z, Qing X, Benda C, Huang Z, Zhang M, Huang Y, Zhang H, Wang L, Lai Y, Ward C, Volpe G, Zhong X, Qin B, Zhuang Q, Esteban MA, Li W. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regen. 2019 Feb 6;8(1):21-29. doi: 10.1016/j.cr.2018.11.001. PMID: 31205685; PMCID: PMC6557759.
• Feng Y, Zhang L, Wu J, Khadka B, Fang Z, Gu J, Tang B, Xiao R, Pan G, Liu J. CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway. J Exp Clin Cancer Res. 2019 Feb 6;38(1):54. doi: 10.1186/s13046-019-1071-9. PMID: 30728056; PMCID: PMC6364482.
• Sui T, Liu D, Liu T, Deng J, Chen M, Xu Y, Song Y, Ouyang H, Lai L, Li Z. LMNA-mutated Rabbits: A Model of Premature Aging Syndrome with Muscular Dystrophy and Dilated Cardiomyopathy. Aging Dis. 2019 Feb 1;10(1):102-115. doi: 10.14336/AD.2018.0209. PMID: 30705772; PMCID: PMC6345340.
• Li H, Bu X, Li K, Wu D. Production of a novel Poria cocos immunomodulatory protein in Pichia pastoris: cloning, expression, purification and activities assays. World J Microbiol Biotechnol. 2019 Jan 24;35(2):27. doi: 10.1007/s11274-019-2602-4. PMID: 30680515.
• Huang R, Wang F, Yang Y, Ma W, Lin Z, Cheng N, Long Y, Deng S, Li Z. Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells. FEBS Open Bio. 2019 Jan 18;9(2):206-225. doi: 10.1002/2211-5463.12570. PMID: 30761248; PMCID: PMC6356177.
• He J, Fu X, Zhang M, He F, Li W, Abdul MM, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nat Commun. 2019 Jan 3;10(1):34. doi: 10.1038/s41467-018-08006-y. PMID: 30604769; PMCID: PMC6318327.
• Wang T, Pei D. Rejuvenation of β cells by epigenetic editing. J Clin Invest. 2019 Jan 2;129(1):51-52. doi: 10.1172/JCI124583. Epub 2018 Nov 26. PMID: 30475229; PMCID: PMC6307952.
• Deng J, Chen M, Liu Z, Song Y, Sui T, Lai L, Li Z. The disrupted balance between hair follicles and sebaceous glands in Hoxc13-ablated rabbits. FASEB J. 2019 Jan;33(1):1226-1234. doi: 10.1096/fj.201800928RR. Epub 2018 Aug 20. PMID: 30125135.
• Pei D, Shu X, Gassama-Diagne A, Thiery JP. Mesenchymal-epithelial transition in development and reprogramming. Nat Cell Biol. 2019 Jan;21(1):44-53. doi: 10.1038/s41556-018-0195-z. Epub 2019 Jan 2. PMID: 30602762.
• Shen L, Yi S, Huang L, Li S, Bai F, Lei S, Breitzig M, Czachor A, Sun H, Zheng Q, Wang F. miR-330-3p promotes lung cancer cells invasion, migration, and metastasis by directly targeting hSOD2b. Biotechnol Appl Biochem. 2019 Jan;66(1):21-32. doi: 10.1002/bab.1691. Epub 2018 Oct 15. PMID: 30192404.

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章

重要文章

所有文章